Q13490: Baculoviral IAP repeat-containing protein 2

General Information

Protein names	- Baculoviral IAP repeat-containing protein 2 - 2.3.2.27 {ECO:0000269\|PubMed:18082613, ECO:0000269\|PubMed:21145488, ECO:0000269\|PubMed:21931591, ECO:0000269\|PubMed:23453969} - Cellular inhibitor of apoptosis 1 - C-IAP1 {ECO:0000303\|PubMed:8548810} - IAP homolog B - Inhibitor of apoptosis protein 2 - hIAP-2 - hIAP2 - RING finger protein 48 - RING-type E3 ubiquitin transferase BIRC2 {ECO:0000305} - TNFR2-TRAF-signaling complex protein 2
Gene names	BIRC2
Organism	Homo sapiens
Protease Family
Protease ID	I32.002
Chromosome location
UniProt ID	Q13490

5 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MHKTASQRLF PGPSYQNIKS IMEDSTILSD WTNSNKQKMK YDFSCELYRM STYSTFPAGV
        70         80         90        100        110        120
PVSERSLARA GFYYTGVNDK VKCFCCGLML DNWKLGDSPI QKHKQLYPSC SFIQNLVSAS
       130        140        150        160        170        180
LGSTSKNTSP MRNSFAHSLS PTLEHSSLFS GSYSSLSPNP LNSRAVEDIS SSRTNPYSYA
       190        200        210        220        230        240
MSTEEARFLT YHMWPLTFLS PSELARAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMSEH
       250        260        270        280        290        300
RRHFPNCPFL ENSLETLRFS ISNLSMQTHA ARMRTFMYWP SSVPVQPEQL ASAGFYYVGR
       310        320        330        340        350        360
NDDVKCFCCD GGLRCWESGD DPWVEHAKWF PRCEFLIRMK GQEFVDEIQG RYPHLLEQLL
       370        380        390        400        410        420
STSDTTGEEN ADPPIIHFGP GESSSEDAVM MNTPVVKSAL EMGFNRDLVK QTVQSKILTT
       430        440        450        460        470        480
GENYKTVNDI VSALLNAEDE KREEEKEKQA EEMASDDLSL IRKNRMALFQ QLTCVLPILD
       490        500        510        520        530        540
NLLKANVINK QEHDIIKQKT QIPLQARELI DTILVKGNAA ANIFKNCLKE IDSTLYKNLF
       550        560        570        580        590        600
VDKNMKYIPT EDVSGLSLEE QLRRLQEERT CKVCMDKEVS VVFIPCGHLV VCQECAPSLR
       610
KCPICRGIIK GTVRTFLS

Isoforms

- Isoform 2 of Baculoviral IAP repeat-containing protein 2

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13490-1-unknown	MHKTAS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13490-5-unknown	ASQRLF...	5	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15394
Q13490-50-unknown	MSTYST...	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68484
Q13490-134-unknown	SFAHSL...	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15395
Q13490-134-unknown	SFAHSL...	134	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141552
Q13490-162-unknown	NSRAVE...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15397
Q13490-162-unknown	NSRAVE...	162	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143107

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SPMRNS	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15395
...SPMRNS	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124729
...SPNPLN	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15397
...SPNPLN	161	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126327
...RTFLS	618	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RTFLS	618	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt64102

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	4	HKTA.\|.ASQR	inferred from experiment	unknown	MEROPS	Du C	Yang QH et al.:Omi/HtrA2 catalytic cleavage of... (S01.278)	12815069,
HTRA2_HUMAN	133	MRNS.\|.SFAH	inferred from experiment	unknown	MEROPS	Du C	Yang QH et al.:Omi/HtrA2 catalytic cleavage of... (S01.278)	12815069,
HTRA2_HUMAN	161	NPLN.\|.NSRA	inferred from experiment	unknown	MEROPS	Du C	Yang QH et al.:Omi/HtrA2 catalytic cleavage of... (S01.278)	12815069,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)