Q13523: Serine/threonine-protein kinase PRP4 homolog

General Information

Protein names	- Serine/threonine-protein kinase PRP4 homolog - 2.7.11.1 - PRP4 kinase - PRP4 pre-mRNA-processing factor 4 homolog
Gene names	PRPF4B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13523

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAETQSLR EQPEMEDANS EKSINEENGE VSEDQSQNKH SRHKKKKHKH RSKHKKHKHS
        70         80         90        100        110        120
SEEDKDKKHK HKHKHKKHKR KEIIDASDKE GMSPAKRTKL DDLALLEDLE KQRALIKAEL
       130        140        150        160        170        180
DNELMEGKVQ SGMGLILQGY ESGSEEEGEI HEKARNGNRS STRSSSTKGK LELVDNKITT
       190        200        210        220        230        240
KKRSKSRSKE RTRHRSDKKK SKGGIEIVKE KTTRSKSKER KKSKSPSKRS KSQDQARKSK
       250        260        270        280        290        300
SPTLRRRSQE KIGKARSPTD DKVKIEDKSK SKDRKKSPII NESRSRDRGK KSRSPVDLRG
       310        320        330        340        350        360
KSKDRRSRSK ERKSKRSETD KEKKPIKSPS KDASSGKENR SPSRRPGRSP KRRSLSPKPR
       370        380        390        400        410        420
DKSRRSRSPL LNDRRSKQSK SPSRTLSPGR RAKSRSLERK RREPERRRLS SPRTRPRDDI
       430        440        450        460        470        480
LSRRERSKDA SPINRWSPTR RRSRSPIRRR SRSPLRRSRS PRRRSRSPRR RDRGRRSRSR
       490        500        510        520        530        540
LRRRSRSRGG RRRRSRSKVK EDKFKGSLSE GMKVEQESSS DDNLEDFDVE EEDEEALIEQ
       550        560        570        580        590        600
RRIQRQAIVQ KYKYLAEDSN MSVPSEPSSP QSSTRTRSPS PDDILERVAA DVKEYERENV
       610        620        630        640        650        660
DTFEASVKAK HNLMTVEQNN GSSQKKLLAP DMFTESDDMF AAYFDSARLR AAGIGKDFKE
       670        680        690        700        710        720
NPNLRDNWTD AEGYYRVNIG EVLDKRYNVY GYTGQGVFSN VVRARDNARA NQEVAVKIIR
       730        740        750        760        770        780
NNELMQKTGL KELEFLKKLN DADPDDKFHC LRLFRHFYHK QHLCLVFEPL SMNLREVLKK
       790        800        810        820        830        840
YGKDVGLHIK AVRSYSQQLF LALKLLKRCN ILHADIKPDN ILVNESKTIL KLCDFGSASH
       850        860        870        880        890        900
VADNDITPYL VSRFYRAPEI IIGKSYDYGI DMWSVGCTLY ELYTGKILFP GKTNNHMLKL
       910        920        930        940        950        960
AMDLKGKMPN KMIRKGVFKD QHFDQNLNFM YIEVDKVTER EKVTVMSTIN PTKDLLADLI
       970        980        990       1000
GCQRLPEDQR KKVHQLKDLL DQILMLDPAK RISINQALQH AFIQEKI

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13523-2-unknown	MAAAET...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13523-2-Acetylation	AAAETQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13523-2-Acetylation	AAAETQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q13523-2-Acetylation	AAAETQ...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q13523-2-Acetylation	AAAETQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13523-15-unknown	MEDANS...	15		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439331
Q13523-28-unknown	NGEVSE...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12090
Q13523-122-unknown	NELMEG...	122		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12091
Q13523-527-unknown	FDVEEE...	527		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12092

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SINEEN	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12090
...KAELDN	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12091
...DNLEDF	526	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12092
...IQEKI	1007	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	27	NEEN.\|.NGEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
GRAB_HUMAN	121	ELDN.\|.NELM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	526	LEDF.\|.FDVE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)