Q13546: Receptor-interacting serine/threonine-protein kinase 1

General Information

Protein names	- Receptor-interacting serine/threonine-protein kinase 1 - 2.7.11.1 {ECO:0000269\|PubMed:23473668} - Cell death protein RIP - Receptor-interacting protein 1 - RIP-1
Gene names	RIPK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13546

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQPDMSLNVI KMKSSDFLES AELDSGGFGK VSLCFHRTQG LMIMKTVYKG PNCIEHNEAL
        70         80         90        100        110        120
LEEAKMMNRL RHSRVVKLLG VIIEEGKYSL VMEYMEKGNL MHVLKAEMST PLSVKGRIIL
       130        140        150        160        170        180
EIIEGMCYLH GKGVIHKDLK PENILVDNDF HIKIADLGLA SFKMWSKLNN EEHNELREVD
       190        200        210        220        230        240
GTAKKNGGTL YYMAPEHLND VNAKPTEKSD VYSFAVVLWA IFANKEPYEN AICEQQLIMC
       250        260        270        280        290        300
IKSGNRPDVD DITEYCPREI ISLMKLCWEA NPEARPTFPG IEEKFRPFYL SQLEESVEED
       310        320        330        340        350        360
VKSLKKEYSN ENAVVKRMQS LQLDCVAVPS SRSNSATEQP GSLHSSQGLG MGPVEESWFA
       370        380        390        400        410        420
PSLEHPQEEN EPSLQSKLQD EANYHLYGSR MDRQTKQQPR QNVAYNREEE RRRRVSHDPF
       430        440        450        460        470        480
AQQRPYENFQ NTEGKGTAYS SAASHGNAVH QPSGLTSQPQ VLYQNNGLYS SHGFGTRPLD
       490        500        510        520        530        540
PGTAGPRVWY RPIPSHMPSL HNIPVPETNY LGNTPTMPFS SLPPTDESIK YTIYNSTGIQ
       550        560        570        580        590        600
IGAYNYMEIG GTSSSLLDST NTNFKEEPAA KYQAIFDNTT SLTDKHLDPI RENLGKHWKN
       610        620        630        640        650        660
CARKLGFTQS QIDEIDHDYE RDGLKEKVYQ MLQKWVMREG IKGATVGKLA QALHQCSRID
       670
LLSSLIYVSQ N

Isoforms

- Isoform 2 of Receptor-interacting serine/threonine-protein kinase 1

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13546-1-unknown	MQPDMS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13546-1-unknown	MQPDMS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87781
Q13546-325-unknown	CVAVPS...	325	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3116
Q13546-325-unknown	CVAVPS...	325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149306
Q13546-559-	STNTNF...	559		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13546-559-unknown	STNTNF...	559	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171265

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SLQLDC	324	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3116
...SLQLDC	324	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132691
...YVSQN	671		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YVSQN	671	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YVSQN	671	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt83399
...YVSQN	671		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	324	QLDC.\|.CVAV	inferred from experiment	unknown	MEROPS	Joe CO	Kim JW et al.:Activation of death-inducing si... (C14.009)	11002422,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)