Q13569: G/T mismatch-specific thymine DNA glycosylase

General Information

Protein names	- G/T mismatch-specific thymine DNA glycosylase - 3.2.2.29 - Thymine-DNA glycosylase - hTDG
Gene names	TDG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13569

4 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEAENAGSYS LQQAQAFYTF PFQQLMAEAP NMAVVNEQQM PEEVPAPAPA QEPVQEAPKG
        70         80         90        100        110        120
RKRKPRTTEP KQPVEPKKPV ESKKSGKSAK SKEKQEKITD TFKVKRKVDR FNGVSEAELL
       130        140        150        160        170        180
TKTLPDILTF NLDIVIIGIN PGLMAAYKGH HYPGPGNHFW KCLFMSGLSE VQLNHMDDHT
       190        200        210        220        230        240
LPGKYGIGFT NMVERTTPGS KDLSSKEFRE GGRILVQKLQ KYQPRIAVFN GKCIYEIFSK
       250        260        270        280        290        300
EVFGVKVKNL EFGLQPHKIP DTETLCYVMP SSSARCAQFP RAQDKVHYYI KLKDLRDQLK
       310        320        330        340        350        360
GIERNMDVQE VQYTFDLQLA QEDAKKMAVK EEKYDPGYEA AYGGAYGENP CSSEPCGFSS
       370        380        390        400        410
NGLIESVELR GESAFSGIPN GQWMTQSFTD QIPSFSNHCG TQEQEEESHA

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13569-1-unknown	MEAENA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13569-26-unknown	MAEAPN...	26	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000390167
Q13569-33-	AVVNEQ...	33		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q13569-33-	AVVNEQ...	33		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q13569-33-	AVVNEQ...	33		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q13569-144-unknown	MAAYKG...	144	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445899

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FWKCLF	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000390167
...PDTETL	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000439825
...EESHA	410	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)