Q14118: Dystroglycan

General Information

Protein names	- Dystroglycan - Dystrophin-associated glycoprotein 1 - Alpha-dystroglycan - Alpha-DG - Beta-dystroglycan - Beta-DG
Gene names	DAG1
Organism	Homo sapiens
Protease Family	S72.001
Protease ID	S72.001
Chromosome location
UniProt ID	Q14118

3 N-termini

10 C-termini

2 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MRMSVGLSLL LPLSGRTFLL LLSVVMAQSH WPSEPSEAVR DWENQLEASM HSVLSDLHEA
        70         80         90        100        110        120
VPTVVGIPDG TAVVGRSFRV TIPTDLIASS GDIIKVSAAG KEALPSWLHW DSQSHTLEGL
       130        140        150        160        170        180
PLDTDKGVHY ISVSATRLGA NGSHIPQTSS VFSIEVYPED HSELQSVRTA SPDPGEVVSS
       190        200        210        220        230        240
ACAADEPVTV LTVILDADLT KMTPKQRIDL LHRMRSFSEV ELHNMKLVPV VNNRLFDMSA
       250        260        270        280        290        300
FMAGPGNAKK VVENGALLSW KLGCSLNQNS VPDIHGVEAP AREGAMSAQL GYPVVGWHIA
       310        320        330        340        350        360
NKKPPLPKRV RRQIHATPTP VTAIGPPTTA IQEPPSRIVP TPTSPAIAPP TETMAPPVRD
       370        380        390        400        410        420
PVPGKPTVTI RTRGAIIQTP TLGPIQPTRV SEAGTTVPGQ IRPTMTIPGY VEPTAVATPP
       430        440        450        460        470        480
TTTTKKPRVS TPKPATPSTD STTTTTRRPT KKPRTPRPVP RVTTKVSITR LETASPPTRI
       490        500        510        520        530        540
RTTTSGVPRG GEPNQRPELK NHIDRVDAWV GTYFEVKIPS DTFYDHEDTT TDKLKLTLKL
       550        560        570        580        590        600
REQQLVGEKS WVQFNSNSQL MYGLPDSSHV GKHEYFMHAT DKGGLSAVDA FEIHVHRRPQ
       610        620        630        640        650        660
GDRAPARFKA KFVGDPALVL NDIHKKIALV KKLAFAFGDR NCSTITLQNI TRGSIVVEWT
       670        680        690        700        710        720
NNTLPLEPCP KEQIAGLSRR IAEDDGKPRP AFSNALEPDF KATSITVTGS GSCRHLQFIP
       730        740        750        760        770        780
VVPPRRVPSE APPTEVPDRD PEKSSEDDVY LHTVIPAVVV AAILLIAGII AMICYRKKRK
       790        800        810        820        830        840
GKLTLEDQAT FIKKGVPIIF ADELDDSKPP PSSSMPLILQ EEKAPLPPPE YPNQSVPETT
       850        860        870        880        890
PLNQDTMGEY TPLRDEDPNA PPYQPPPPFT APMEGKGSRP KNMTPYRSPP PYVPP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 10 C-termini - 2 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14118-30-unknown	HWPSEP...	30	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14118-654-unknown	SIVVEW...	654	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14118-654-unknown	SIVVEW...	654	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8458
Q14118-716-unknown	LQFIPV...	716	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26462

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAVRDW	41	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000387859
...ASMHSV	52	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000415321
...IPTDLI	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410145
...TDLIAS	88	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405859
...GDIIKV	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000401382
...EALPSW	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412067
...QSHTLE	117	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388833
...NITRGS	653	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...NITRGS	653	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8458
...GSCRHL	715	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26462
...PYVPP	895	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
DAG1_HUMAN	653	TRGS.\|.SIVV	inferred from experiment	unknown	MEROPS	Martin PT	Jayasinha V et al.:Inhibition of dystroglycan clea... (S72.001)	12798792,
MMP9_HUMAN	715	CRHL.\|.LQFI	inferred from experiment	unknown	MEROPS	Coletta M	Bozzi M et al.:Enzymatic processing of beta-dy... (M10.004)	19946898,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
DAG1_HUMAN	653	TRGS.\|.SIVV	inferred from experiment	unknown	MEROPS	Martin PT	Jayasinha V et al.:Inhibition of dystroglycan clea... (S72.001)	12798792,