Q14146: Unhealthy ribosome biogenesis protein 2 homolog

General Information

Protein names	- Unhealthy ribosome biogenesis protein 2 homolog
Gene names	URB2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14146

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ SLVAFYKKKL
        70         80         90        100        110        120
ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV KIINERVAEF SLSGSQRNIC
       130        140        150        160        170        180
AVLRCCQGIL STPALAVIYT AKQELMVALL SQLCWSACRQ PEGAVVAQLF EVIHLALGHY
       190        200        210        220        230        240
LLILQQQVNP RRAFGDVTAH LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM
       250        260        270        280        290        300
FRGGIFQPEL LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV
       310        320        330        340        350        360
ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST SDWTTELLVV
       370        380        390        400        410        420
EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH AQAPIPAWFR CLKTLISLNH
       430        440        450        460        470        480
LILEPDLDDL LASAWIDAEV TEFRTKKAQE ALIRTVFQTY AKLRQVPRLF EEVLGVICRP
       490        500        510        520        530        540
AAEALRQPVL ASGPSTVLSA CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL
       550        560        570        580        590        600
SLSLLLHCIM FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ
       610        620        630        640        650        660
KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG VKTQHWKKIE
       670        680        690        700        710        720
KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL RCDAAFIIGS GRKSLNQRTT
       730        740        750        760        770        780
ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL ISYLCPDDVG YLASVLLRTL PMGKAQEVSI
       790        800        810        820        830        840
DEEAYITLEK ISKAFLHSPL FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW
       850        860        870        880        890        900
LFEKDHMVVG HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV
       910        920        930        940        950        960
ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG YLQKGKSARS
       970        980        990       1000       1010       1020
VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV IGTFLEELMQ MLIQMKLSLV
      1030       1040       1050       1060       1070       1080
LNFRKITAFL SSSKPYTEAA SSKQLENQNP QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA
      1090       1100       1110       1120       1130       1140
PAALSELLQQ VVLQTGAVLQ LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS
      1150       1160       1170       1180       1190       1200
QGSDRTLLSH VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT
      1210       1220       1230       1240       1250       1260
SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI LQGLDVSNMW
      1270       1280       1290       1300       1310       1320
KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA LTLLNREASQ EQPVSLTVVG
      1330       1340       1350       1360       1370       1380
PVLDVLAALL RQGEEAIGNP HHVSLAFSIL LTVPLDHLKP LEYGSVFPRL HNVLFSILQC
      1390       1400       1410       1420       1430       1440
HPKVMLKAIP SFLNSFNRLV FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE
      1450       1460       1470       1480       1490       1500
EFAVFSPFMV AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI
      1510       1520
FKELYNDYLK YHKAKHEGEK RYTA

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14146-1-unknown	MAAVYS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14146-1135-	GGADIS...	1135		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14146-1135-	GGADIS...	1135		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14146-1135-	GGADIS...	1135		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14146-1385-unknown	MLKAIP...	1385	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000395107

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PAVKSL	1468	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000395107
	...KRYTA	1524	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)