Q14155: Rho guanine nucleotide exchange factor 7

General Information

Protein names	- Rho guanine nucleotide exchange factor 7 - Beta-Pix - COOL-1 - PAK-interacting exchange factor beta - p85
Gene names	ARHGEF7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14155

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Rho guanine nucleotide exchange factor 7 - Isoform 2 of Rho guanine nucleotide exchange factor 7 - Isoform 3 of Rho guanine nucleotide exchange factor 7 - Isoform 5 of Rho guanine nucleotide exchange factor 7 - Isoform 6 of Rho guanine nucleotide exchange factor 7

Sequence View

        10         20         30         40         50         60
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
        70         80         90        100        110        120
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
       130        140        150        160        170        180
VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
       190        200        210        220        230        240
DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
       250        260        270        280        290        300
VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
       310        320        330        340        350        360
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
       370        380        390        400        410        420
YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
       430        440        450        460        470        480
ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
       490        500        510        520        530        540
TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
       550        560        570        580        590        600
NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
       610        620        630        640        650        660
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
       670        680        690        700        710        720
LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
       730        740        750        760        770        780
CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
       790        800
TAHSYRMGST SRKSCCSYIS HQN         10         20         30         40         50         60
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
        70         80         90        100        110        120
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
       130        140        150        160        170        180
VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
       190        200        210        220        230        240
DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
       250        260        270        280        290        300
VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
       310        320        330        340        350        360
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
       370        380        390        400        410        420
YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
       430        440        450        460        470        480
ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
       490        500        510        520        530        540
TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
       550        560        570        580        590        600
NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
       610        620        630        640        650        660
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
       670        680        690        700        710        720
LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
       730        740        750        760        770        780
CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
       790        800
TAHSYRMGST SRKSCCSYIS HQN         10         20         30         40         50         60
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
        70         80         90        100        110        120
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
       130        140        150        160        170        180
VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
       190        200        210        220        230        240
DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
       250        260        270        280        290        300
VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
       310        320        330        340        350        360
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
       370        380        390        400        410        420
YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
       430        440        450        460        470        480
ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
       490        500        510        520        530        540
TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
       550        560        570        580        590        600
NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
       610        620        630        640        650        660
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
       670        680        690        700        710        720
LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
       730        740        750        760        770        780
CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
       790        800
TAHSYRMGST SRKSCCSYIS HQN         10         20         30         40         50         60
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
        70         80         90        100        110        120
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
       130        140        150        160        170        180
VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
       190        200        210        220        230        240
DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
       250        260        270        280        290        300
VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
       310        320        330        340        350        360
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
       370        380        390        400        410        420
YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
       430        440        450        460        470        480
ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
       490        500        510        520        530        540
TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
       550        560        570        580        590        600
NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
       610        620        630        640        650        660
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
       670        680        690        700        710        720
LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
       730        740        750        760        770        780
CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
       790        800
TAHSYRMGST SRKSCCSYIS HQN         10         20         30         40         50         60
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
        70         80         90        100        110        120
RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
       130        140        150        160        170        180
VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
       190        200        210        220        230        240
DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
       250        260        270        280        290        300
VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
       310        320        330        340        350        360
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
       370        380        390        400        410        420
YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
       430        440        450        460        470        480
ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
       490        500        510        520        530        540
TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
       550        560        570        580        590        600
NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
       610        620        630        640        650        660
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
       670        680        690        700        710        720
LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
       730        740        750        760        770        780
CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
       790        800
TAHSYRMGST SRKSCCSYIS HQN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14155-1-unknown	MNSAEQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14155-1-unknown	MNSAEQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67396
Q14155-1-unknown	MNSAEQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67397
Q14155-1-unknown	MNSAEQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67398
Q14155-70-unknown	IREFLR...	70		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q14155-136-unknown	GLGSDS...	136			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14155-136-unknown	GLGSDS...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159423
Q14155-136-unknown	GLGSDS...	136		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159422
Q14155-179-unknown	MTDNSN...	179		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67399
Q14155-179-unknown	MTDNSN...	179		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99854
Q14155-179-unknown	MTDNSN...	179		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99856
Q14155-179-unknown	MTDNSN...	179		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99855
Q14155-180-acetylation	TDNSNN...	180	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q14155-180-acetylation	TDNSNN...	180	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163321
Q14155-180-acetylation	TDNSNN...	180	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163322
Q14155-180-acetylation	TDNSNN...	180	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163324
Q14155-180-acetylation	TDNSNN...	180	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163323
Q14155-702-unknown	KSTAAL...	702		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169313
Q14155-702-unknown	KSTAAL...	702		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169314
Q14155-702-unknown	KSTAAL...	702		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169316
Q14155-702-unknown	KSTAAL...	702		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt169315
Q14155-702-	KSTAAL...	702			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q14155-711-unknown	AQILKV...	711		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12199
Q14155-711-unknown	AQILKV...	711		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153793
Q14155-711-unknown	AQILKV...	711		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154892
Q14155-711-unknown	AQILKV...	711		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155430
Q14155-711-unknown	AQILKV...	711		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155766

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALEEDA	710	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12199
...ALEEDA	710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137215
...ALEEDA	710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138319
...ALEEDA	710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138864
...ALEEDA	710	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139212
...ISHQN	803	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ISHQN	803	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63017
...ISHQN	803	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63014
...ISHQN	803	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63015

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	710	EEDA.\|.AQIL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)