Q14657: EKC/KEOPS complex subunit LAGE3 {ECO:0000305}

General Information

Protein names	- EKC/KEOPS complex subunit LAGE3 {ECO:0000305} - L antigen family member 3 {ECO:0000303\|PubMed:12384295} - Protein ESO-3 {ECO:0000303\|PubMed:12384295} - Protein ITBA2 {ECO:0000303\|PubMed:8786131}
Gene names	LAGE3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14657

6 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRDADADAGG GADGGDGRGG HSCRGGVDTA AAPAGGAPPA HAPGPGRDAA SAARGSRMRP
        70         80         90        100        110        120
HIFTLSVPFP TPLEAEIAHG SLAPDAEPHQ RVVGKDLTVS GRILVVRWKA EDCRLLRISV
       130        140
INFLDQLSLV VRTMQRFGPP VSR

Isoforms

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14657-1-unknown	MRDADA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14657-21-	HSCRGG...	21		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14657-29-unknown	TAAAPA...	29		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14657-29-	TAAAPA...	29		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q14657-30-	AAAPAG...	30		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14657-30-	AAAPAG...	30		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q14657-31-	AAPAGG...	31		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q14657-31-	AAPAGG...	31		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...RILVVR	106	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000383988
	...PPVSR	143	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)