Q14693: Phosphatidate phosphatase LPIN1

General Information

Protein names	- Phosphatidate phosphatase LPIN1 - 3.1.3.4 - Lipin-1
Gene names	LPIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14693

5 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphatidate phosphatase LPIN1 - Isoform 3 of Phosphatidate phosphatase LPIN1 - Isoform 4 of Phosphatidate phosphatase LPIN1 - Isoform 5 of Phosphatidate phosphatase LPIN1 - Isoform 6 of Phosphatidate phosphatase LPIN1 - Isoform 7 of Phosphatidate phosphatase LPIN1

Sequence View

        10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA         10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA         10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA         10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA         10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA         10         20         30         40         50         60
MNYVGQLAGQ VFVTVKELYK GLNPATLSGC IDIIVIRQPN GNLQCSPFHV RFGKMGVLRS
        70         80         90        100        110        120
REKVVDIEIN GESVDLHMKL GDNGEAFFVQ ETDNDQEVIP MHLATSPILS EGASRMECQL
       130        140        150        160        170        180
KRGSVDRMRG LDPSTPAQVI APSETPSSSS VVKKRRKRRR KSQLDSLKRD DNMNTSEDED
       190        200        210        220        230        240
MFPIEMSSDE AMELLESSRT LPNDIPPFQD DIPEENLSLA VIYPQSASYP NSDREWSPTP
       250        260        270        280        290        300
SPSGSRPSTP KSDSELVSKS TERTGQKNPE MLWLWGELPQ AAKSSSPHKM KESSPLSSRK
       310        320        330        340        350        360
ICDKSHFQAI HSESSDTFSD QSPTLVGGAL LDQNKPQTEM QFVNEEDLET LGAAAPLLPM
       370        380        390        400        410        420
IEELKPPSAS VVQTANKTDS PSRKRDKRSR HLGADGVYLD DLTDMDPEVA ALYFPKNGDP
       430        440        450        460        470        480
SGLAKHASDN GARSANQSPQ SVGSSGVDSG VESTSDGLRD LPSIAISLCG GLSDHREITK
       490        500        510        520        530        540
DAFLEQAVSY QQFVDNPAII DDPNLVVKIG SKYYNWTTAA PLLLAMQAFQ KPLPKATVES
       550        560        570        580        590        600
IMRDKMPKKG GRWWFSWRGR NTTIKEESKP EQCLAGKAHS TGEQPPQLSL ATRVKHESSS
       610        620        630        640        650        660
SDEERAAAKP SNAGHLPLLP NVSYKKTLRL TSEQLKSLKL KNGPNDVVFS VTTQYQGTCR
       670        680        690        700        710        720
CEGTIYLWNW DDKVIISDID GTITRSDTLG HILPTLGKDW THQGIAKLYH KVSQNGYKFL
       730        740        750        760        770        780
YCSARAIGMA DMTRGYLHWV NERGTVLPQG PLLLSPSSLF SALHREVIEK KPEKFKVQCL
       790        800        810        820        830        840
TDIKNLFFPN TEPFYAAFGN RPADVYSYKQ VGVSLNRIFT VNPKGELVQE HAKTNISSYV
       850        860        870        880        890
RLCEVVDHVF PLLKRSHSSD FPCSDTFSNF TFWREPLPPF ENQDIHSASA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14693-1-unknown	MNYVGQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14693-1-unknown	MNYVGQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79818
Q14693-1-unknown	MNYVGQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79819
Q14693-1-unknown	MNYVGQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104231
Q14693-1-unknown	MNYVGQ...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104232
Q14693-166-unknown	SLKRDD...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176879
Q14693-166-unknown	SLKRDD...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176880
Q14693-166-unknown	SLKRDD...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176878
Q14693-166-unknown	SLKRDD...	166	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176881
Q14693-166-	SLKRDD...	166		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q14693-271-unknown	MLWLWG...	271	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000379404
Q14693-271-unknown	MLWLWG...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198633
Q14693-271-unknown	MLWLWG...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198635
Q14693-271-unknown	MLWLWG...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198634
Q14693-271-unknown	MLWLWG...	271	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198632
Q14693-500-unknown	IDDPNL...	500	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413714
Q14693-500-unknown	IDDPNL...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199711
Q14693-500-unknown	IDDPNL...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199713
Q14693-500-unknown	IDDPNL...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199712
Q14693-500-unknown	IDDPNL...	500	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199710

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PATLSG	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000392424
...PATLSG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153750
...PATLSG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153751
...PATLSG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153749
...PATLSG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153752
...TDNDQE	96	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412578
...TDNDQE	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154320
...TDNDQE	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154321
...TDNDQE	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154319
...TDNDQE	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154322
...GTIYLW	667	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413714
...HSASA	890	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HSASA	890	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75435
...HSASA	890	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75437
...HSASA	890	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75436
...HSASA	890	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75438

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)