Q14CB8: Rho GTPase-activating protein 19

General Information

Protein names	- Rho GTPase-activating protein 19 - Rho-type GTPase-activating protein 19
Gene names	ARHGAP19
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14CB8

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rho GTPase-activating protein 19 - Isoform 3 of Rho GTPase-activating protein 19 - Isoform 4 of Rho GTPase-activating protein 19 - Isoform 5 of Rho GTPase-activating protein 19 - Isoform 6 of Rho GTPase-activating protein 19 - Isoform 7 of Rho GTPase-activating protein 19

Sequence View

        10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL         10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL         10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL         10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL         10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL         10         20         30         40         50         60
MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL
        70         80         90        100        110        120
VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE
       130        140        150        160        170        180
GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL
       190        200        210        220        230        240
KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR
       250        260        270        280        290        300
NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM
       310        320        330        340        350        360
IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP
       370        380        390        400        410        420
HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS
       430        440        450        460        470        480
RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL
       490
KWSEGKKEGK KGFL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q14CB8-1-unknown	MATEAQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14CB8-1-unknown	MATEAQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87626
Q14CB8-1-unknown	MATEAQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87629
Q14CB8-1-unknown	MATEAQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87630
Q14CB8-1-unknown	MATEAQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87631
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162924
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162925
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162926
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162927
Q14CB8-2-acetylation	ATEAQS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q14CB8-31-unknown	SSLRGQ...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12325
Q14CB8-31-unknown	SSLRGQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136971
Q14CB8-31-unknown	SSLRGQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137595
Q14CB8-31-unknown	SSLRGQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137597
Q14CB8-31-unknown	SSLRGQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137598
Q14CB8-31-unknown	SSLRGQ...	31		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137599
Q14CB8-383-unknown	MPESAK...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87628
Q14CB8-383-unknown	MPESAK...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100208
Q14CB8-383-unknown	MPESAK...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100207
Q14CB8-383-unknown	MPESAK...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100209
Q14CB8-383-unknown	MPESAK...	383		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100210

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VICNDS	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12325
...VICNDS	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120586
...VICNDS	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120588
...VICNDS	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120589
...VICNDS	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120590
...KKGFL	494	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKGFL	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83246
...KKGFL	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83248
...KKGFL	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83249
...KKGFL	494	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt83245

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	30	CNDS.\|.SSLR	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)