Q15031: Probable leucine--tRNA ligase, mitochondrial

General Information

Protein names	- Probable leucine--tRNA ligase, mitochondrial - 6.1.1.4 - Leucyl-tRNA synthetase - LeuRS
Gene names	LARS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15031

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MASVWQRLGF YASLLKRQLN GGPDVIKWER RVIPGCTRSI YSATGKWTKE YTLQTRKDVE
        70         80         90        100        110        120
KWWHQRIKEQ ASKISEADKS KPKFYVLSMF PYPSGKLHMG HVRVYTISDT IARFQKMRGM
       130        140        150        160        170        180
QVINPMGWDA FGLPAENAAV ERNLHPQSWT QSNIKHMRKQ LDRLGLCFSW DREITTCLPD
       190        200        210        220        230        240
YYKWTQYLFI KLYEAGLAYQ KEALVNWDPV DQTVLANEQV DEHGCSWRSG AKVEQKYLRQ
       250        260        270        280        290        300
WFIKTTAYAK AMQDALADLP EWYGIKGMQA HWIGDCVGCH LDFTLKVHGQ ATGEKLTAYT
       310        320        330        340        350        360
ATPEAIYGTS HVAISPSHRL LHGHSSLKEA LRMALVPGKD CLTPVMAVNM LTQQEVPVVI
       370        380        390        400        410        420
LAKADLEGSL DSKIGIPSTS SEDTILAQTL GLAYSEVIET LPDGTERLSS SAEFTGMTRQ
       430        440        450        460        470        480
DAFLALTQKA RGKRVGGDVT SDKLKDWLIS RQRYWGTPIP IVHCPVCGPT PVPLEDLPVT
       490        500        510        520        530        540
LPNIASFTGK GGPPLAMASE WVNCSCPRCK GAAKRETDTM DTFVDSAWYY FRYTDPHNPH
       550        560        570        580        590        600
SPFNTAVADY WMPVDLYIGG KEHAVMHLFY ARFFSHFCHD QKMVKHREPF HKLLAQGLIK
       610        620        630        640        650        660
GQTFRLPSGQ YLQREEVDLT GSVPVHAKTK EKLEVTWEKM SKSKHNGVDP EEVVEQYGID
       670        680        690        700        710        720
TIRLYILFAA PPEKDILWDV KTDALPGVLR WQQRLWTLTT RFIEARASGK SPQPQLLSNK
       730        740        750        760        770        780
EKAEARKLWE YKNSVISQVT THFTEDFSLN SAISQLMGLS NALSQASQSV ILHSPEFEDA
       790        800        810        820        830        840
LCALMVMAAP LAPHVTSEIW AGLALVPRKL CAHYTWDASV LLQAWPAVDP EFLQQPEVVQ
       850        860        870        880        890        900
MAVLINNKAC GKIPVPQQVA RDQDKVHEFV LQSELGVRLL QGRSIKKSFL SPRTALINFL

VQD

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15031-0-unknown	DMASVW...	0	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15031-40-	IYSATG...	40		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15031-40-	IYSATG...	40		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15031-40-	IYSATG...	40		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15031-391-	GLAYSE...	391		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15031-391-	GLAYSE...	391		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TIARFQ	114	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000401388
...KWTQYL	187	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406611
...FLVQD	903	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FLVQD	903		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FLVQD	903		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)