Q15118: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

General Information

Protein names	- Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial - 2.7.11.2 - Pyruvate dehydrogenase kinase isoform 1 - PDH kinase 1
Gene names	PDK1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15118

5 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRLARLLRGA ALAGPGPGLR AAGFSRSFSS DSGSSPASER GVPGQVDFYA RFSPSPLSMK
        70         80         90        100        110        120
QFLDFGSVNA CEKTSFMFLR QELPVRLANI MKEISLLPDN LLRTPSVQLV QSWYIQSLQE
       130        140        150        160        170        180
LLDFKDKSAE DAKAIYDFTD TVIRIRNRHN DVIPTMAQGV IEYKESFGVD PVTSQNVQYF
       190        200        210        220        230        240
LDRFYMSRIS IRMLLNQHSL LFGGKGKGSP SHRKHIGSIN PNCNVLEVIK DGYENARRLC
       250        260        270        280        290        300
DLYYINSPEL ELEELNAKSP GQPIQVVYVP SHLYHMVFEL FKNAMRATME HHANRGVYPP
       310        320        330        340        350        360
IQVHVTLGNE DLTVKMSDRG GGVPLRKIDR LFNYMYSTAP RPRVETSRAV PLAGFGYGLP
       370        380        390        400        410        420
ISRLYAQYFQ GDLKLYSLEG YGTDAVIYIK ALSTDSIERL PVYNKAAWKH YNTNHEADDW
       430
CVPSREPKDM TTFRSA

Isoforms

- Isoform 2 of [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15118-29-unknown	SSDSGS...	29	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15118-29-unknown	SSDSGS...	29		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15118-29-unknown	SSDSGS...	29		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q15118-29-	SSDSGS...	29		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q15118-59-unknown	MKQFLD...	59	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399160
Q15118-77-unknown	MFLRQE...	77	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399558
Q15118-77-unknown	MFLRQE...	77	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000388366
Q15118-77-unknown	MFLRQE...	77	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000438567
Q15118-156-unknown	MAQGVI...	156	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437502

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LEVIKD	230	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399558
...LEVIKD	230	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000388366
...LGNEDL	311	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399160
...TFRSA	436	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)