Q15813: Tubulin-specific chaperone E

General Information

Protein names	- Tubulin-specific chaperone E - Tubulin-folding cofactor E
Gene names	TBCE
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15813

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSDTLTADVI GRRVEVNGEH ATVRFAGVVP PVAGPWLGVE WDNPERGKHD GSHEGTVYFK
        70         80         90        100        110        120
CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTIGNKP VETIGFDSIM
       130        140        150        160        170        180
KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRKVDL SKNLLSSWDE VIHIADQLRH
       190        200        210        220        230        240
LEVLNVSENK LKFPSGSVLT GTLSVLKVLV LNQTGITWAE VLRCVAGCPG LEELYLESNN
       250        260        270        280        290        300
IFISERPTDV LQTVKLLDLS SNQLIDENQL YLIAHLPRLE QLILSDTGIS SLHFPDAGIG
       310        320        330        340        350        360
CKTSMFPSLK YLVVNDNQIS QWSFFNELEK LPSLRALSCL RNPLTKEDKE AETARLLIIA
       370        380        390        400        410        420
SIGQLKTLNK CEILPEERRR AELDYRKAFG NEWKQAGGHK DPEKNRLSEE FLTAHPRYQF
       430        440        450        460        470        480
LCLKYGAPED WELKTQQPLM LKNQLLTLKI KYPHQLDQKV LEKQLPGSMT IQKVKGLLSR
       490        500        510        520
LLKVPVSDLL LSYESPKKPG REIELENDLK SLQFYSVENG DCLLVRW

Isoforms

- Isoform 2 of Tubulin-specific chaperone E

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15813-1-unknown	MSDTLT...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91643
Q15813-2-unknown	MSDTLT...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15813-2-Acetylation	SDTLTA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15813-2-Acetylation	SDTLTA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q15813-2-Acetylation	SDTLTA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q15813-2-Acetylation	SDTLTA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q15813-2-Acetylation	SDTLTA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111029
Q15813-118-unknown	SIMKQQ...	118		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12386
Q15813-118-unknown	SIMKQQ...	118		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143367
Q15813-118-	SIMKQQ...	118			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIGFDS	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12386
...TIGFDS	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126599
...LLVRW	527	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LLVRW	527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt87261

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	117	GFDS.\|.SIMK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)