Q16512: Serine/threonine-protein kinase N1
Protein names | - Serine/threonine-protein kinase N1 - 2.7.11.13 {ECO:0000269|PubMed:18066052} - Protease-activated kinase 1 - PAK-1 - Protein kinase C-like 1 - Protein kinase C-like PKN - Protein kinase PKN-alpha - Protein-kinase C-related kinase 1 - Serine-threonine protein kinase N |
---|---|
Gene names | PKN1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q16512 |
8
N-termini
6
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR
70 80 90 100 110 120
RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL PDPAATHDGP QSPGAGGPTC
130 140 150 160 170 180
SATNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSTKDR KLLLTAQQML QDSKTKIDII
190 200 210 220 230 240
RMQLRRALQA GQLENQAAPD DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS
250 260 270 280 290 300
AAKAPDRKAV SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF
310 320 330 340 350 360
STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG PGTPDSRPPF
370 380 390 400 410 420
LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT VVGQTSWKPC GPNAWDQSFT
430 440 450 460 470 480
LELERARELE LAVFWRDQRG LCALKFLKLE DFLDNERHEV QLDMEPQGCL VAEVTFRNPV
490 500 510 520 530 540
IERIPRLRRQ KKIFSKQQGK AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS
550 560 570 580 590 600
EARTTGDISV EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA
610 620 630 640 650 660
LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD IVARDEVESL
670 680 690 700 710 720
MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG GDLMLHIHSD VFSEPRAIFY
730 740 750 760 770 780
SACVVLGLQF LHEHKIVYRD LKLDNLLLDT EGYVKIADFG LCKEGMGYGD RTSTFCGTPE
790 800 810 820 830 840
FLAPEVLTDT SYTRAVDWWG LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA
850 860 870 880 890 900
EAIGIMRRLL RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD
910 920 930 940
VSNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC
Isoforms
- Isoform 2 of Serine/threonine-protein kinase N1 - Isoform 3 of Serine/threonine-protein kinase N1Sequence View
10 20 30 40 50 60
MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR
70 80 90 100 110 120
RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL PDPAATHDGP QSPGAGGPTC
130 140 150 160 170 180
SATNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSTKDR KLLLTAQQML QDSKTKIDII
190 200 210 220 230 240
RMQLRRALQA GQLENQAAPD DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS
250 260 270 280 290 300
AAKAPDRKAV SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF
310 320 330 340 350 360
STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG PGTPDSRPPF
370 380 390 400 410 420
LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT VVGQTSWKPC GPNAWDQSFT
430 440 450 460 470 480
LELERARELE LAVFWRDQRG LCALKFLKLE DFLDNERHEV QLDMEPQGCL VAEVTFRNPV
490 500 510 520 530 540
IERIPRLRRQ KKIFSKQQGK AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS
550 560 570 580 590 600
EARTTGDISV EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA
610 620 630 640 650 660
LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD IVARDEVESL
670 680 690 700 710 720
MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG GDLMLHIHSD VFSEPRAIFY
730 740 750 760 770 780
SACVVLGLQF LHEHKIVYRD LKLDNLLLDT EGYVKIADFG LCKEGMGYGD RTSTFCGTPE
790 800 810 820 830 840
FLAPEVLTDT SYTRAVDWWG LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA
850 860 870 880 890 900
EAIGIMRRLL RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD
910 920 930 940
VSNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC
10 20 30 40 50 60
MASDAVQSEP RSWSLLEQLG LAGADLAAPG VQQQLELERE RLRREIRKEL KLKEGAENLR
70 80 90 100 110 120
RATTDLGRSL GPVELLLRGS SRRLDLLHQQ LQELHAHVVL PDPAATHDGP QSPGAGGPTC
130 140 150 160 170 180
SATNLSRVAG LEKQLAIELK VKQGAENMIQ TYSNGSTKDR KLLLTAQQML QDSKTKIDII
190 200 210 220 230 240
RMQLRRALQA GQLENQAAPD DTQGSPDLGA VELRIEELRH HFRVEHAVAE GAKNVLRLLS
250 260 270 280 290 300
AAKAPDRKAV SEAQEKLTES NQKLGLLREA LERRLGELPA DHPKGRLLRE ELAAASSAAF
310 320 330 340 350 360
STRLAGPFPA THYSTLCKPA PLTGTLEVRV VGCRDLPETI PWNPTPSMGG PGTPDSRPPF
370 380 390 400 410 420
LSRPARGLYS RSGSLSGRSS LKAEAENTSE VSTVLKLDNT VVGQTSWKPC GPNAWDQSFT
430 440 450 460 470 480
LELERARELE LAVFWRDQRG LCALKFLKLE DFLDNERHEV QLDMEPQGCL VAEVTFRNPV
490 500 510 520 530 540
IERIPRLRRQ KKIFSKQQGK AFQRARQMNI DVATWVRLLR RLIPNATGTG TFSPGASPGS
550 560 570 580 590 600
EARTTGDISV EKLNLGTDSD SSPQKSSRDP PSSPSSLSSP IQESTAPELP SETQETPGPA
610 620 630 640 650 660
LCSPLRKSPL TLEDFKFLAV LGRGHFGKVL LSEFRPSGEL FAIKALKKGD IVARDEVESL
670 680 690 700 710 720
MCEKRILAAV TSAGHPFLVN LFGCFQTPEH VCFVMEYSAG GDLMLHIHSD VFSEPRAIFY
730 740 750 760 770 780
SACVVLGLQF LHEHKIVYRD LKLDNLLLDT EGYVKIADFG LCKEGMGYGD RTSTFCGTPE
790 800 810 820 830 840
FLAPEVLTDT SYTRAVDWWG LGVLLYEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSA
850 860 870 880 890 900
EAIGIMRRLL RRNPERRLGS SERDAEDVKK QPFFRTLGWE ALLARRLPPP FVPTLSGRTD
910 920 930 940
VSNFDEEFTG EAPTLSPPRD ARPLTAAEQA AFLDFDFVAG GC
Protein Neighborhood
Domains & Features
8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q16512-1-unknown | MASDAV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt85440 | |||
Q16512-2-unknown | MASDAV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q16512-2-Acetylation | ASDAVQ... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q16512-2-Acetylation | ASDAVQ... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q16512-2-Acetylation | ASDAVQ... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q16512-2-Acetylation | ASDAVQ... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt111732 | ||
Q16512-109-unknown | GPQSPG... | 109 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2224 | |||
Q16512-109-unknown | GPQSPG... | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt142892 | |||
Q16512-109-unknown | GPQSPG... | 109 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt143248 | |||
Q16512-201-unknown | DTQGSP... | 201 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12389 | |||
Q16512-201-unknown | DTQGSP... | 201 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146599 | |||
Q16512-201-unknown | DTQGSP... | 201 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146795 | |||
Q16512-455-unknown | NERHEV... | 455 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2227 | |||
Q16512-455-unknown | NERHEV... | 455 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152844 | |||
Q16512-455-unknown | NERHEV... | 455 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt152929 | |||
Q16512-559-unknown | SDSSPQ... | 559 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2230 | |||
Q16512-559-unknown | SDSSPQ... | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154101 | |||
Q16512-559-unknown | SDSSPQ... | 559 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154174 | |||
Q16512-561-unknown | SSPQKS... | 561 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2233 | |||
Q16512-561-unknown | SSPQKS... | 561 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154129 | |||
Q16512-561-unknown | SSPQKS... | 561 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154192 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AATHDG | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2224 | |||
...AATHDG | 108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126101 | |||
...AATHDG | 108 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt126477 | |||
...QAAPDD | 200 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12389 | |||
...QAAPDD | 200 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129906 | |||
...QAAPDD | 200 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130117 | |||
...EDFLDN | 454 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2227 | |||
...EDFLDN | 454 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136269 | |||
...EDFLDN | 454 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136355 | |||
...NLGTDS | 558 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2230 | |||
...NLGTDS | 558 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137520 | |||
...NLGTDS | 558 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137594 | |||
...GTDSDS | 560 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC2233 | |||
...GTDSDS | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137549 | |||
...GTDSDS | 560 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137612 | |||
...VAGGC | 942 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...VAGGC | 942 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81057 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CASP3_HUMAN | 108 | THDG.|.GPQS | inferred from experiment | unknown | MEROPS | Ono Y | Takahashi M et al.:Proteolytic activation of PKN b... (C14.003) | 9751706, |
GRAB_HUMAN | 200 | APDD.|.DTQG | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
CASP3_HUMAN | 454 | FLDN.|.NERH | inferred from experiment | unknown | MEROPS | Ono Y | Takahashi M et al.:Proteolytic activation of PKN b... (C14.003) | 9751706, |
CASP3_HUMAN | 558 | GTDS.|.SDSS | inferred from experiment | unknown | MEROPS | Ono Y | Takahashi M et al.:Proteolytic activation of PKN b... (C14.003) | 9751706, |
CASP3_HUMAN | 560 | DSDS.|.SSPQ | inferred from experiment | unknown | MEROPS | Ono Y | Takahashi M et al.:Proteolytic activation of PKN b... (C14.003) | 9751706, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|