Q16513: Serine/threonine-protein kinase N2

General Information

Protein names	- Serine/threonine-protein kinase N2 - 2.7.11.13 - PKN gamma - Protein kinase C-like 2 - Protein-kinase C-related kinase 2
Gene names	PKN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16513

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein kinase N2 - Isoform 3 of Serine/threonine-protein kinase N2 - Isoform 4 of Serine/threonine-protein kinase N2 - Isoform 5 of Serine/threonine-protein kinase N2

Sequence View

        10         20         30         40         50         60
MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RIKREIRKEL
        70         80         90        100        110        120
KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDITDCPR
       130        140        150        160        170        180
TPDTPNNDPR CSTSNNRLKA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL
       190        200        210        220        230        240
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM
       250        260        270        280        290        300
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA
       310        320        330        340        350        360
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK ATSVALPGWS
       370        380        390        400        410        420
PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD NTVVGQTSWK PISNQSWDQK
       430        440        450        460        470        480
FTLELDRSRE LEISVYWRDW RSLCAVKFLR LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN
       490        500        510        520        530        540
PVIERRPKLQ RQKKIFSKQQ GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV
       550        560        570        580        590        600
PTTVPVVDVR IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG
       610        620        630        640        650        660
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF QFNLQDFRCC
       670        680        690        700        710        720
AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD SLMCEKRIFE TVNSVRHPFL
       730        740        750        760        770        780
VNLFACFQTK EHVCFVMEYA AGGDLMMHIH TDVFSEPRAV FYAACVVLGL QYLHEHKIVY
       790        800        810        820        830        840
RDLKLDNLLL DTEGFVKIAD FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW
       850        860        870        880        890        900
WGLGVLIYEM LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL
       910        920        930        940        950        960
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF TSEAPILTPP
       970        980
REPRILSEEE QEMFRDFDYI ADWC         10         20         30         40         50         60
MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RIKREIRKEL
        70         80         90        100        110        120
KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDITDCPR
       130        140        150        160        170        180
TPDTPNNDPR CSTSNNRLKA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL
       190        200        210        220        230        240
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM
       250        260        270        280        290        300
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA
       310        320        330        340        350        360
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK ATSVALPGWS
       370        380        390        400        410        420
PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD NTVVGQTSWK PISNQSWDQK
       430        440        450        460        470        480
FTLELDRSRE LEISVYWRDW RSLCAVKFLR LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN
       490        500        510        520        530        540
PVIERRPKLQ RQKKIFSKQQ GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV
       550        560        570        580        590        600
PTTVPVVDVR IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG
       610        620        630        640        650        660
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF QFNLQDFRCC
       670        680        690        700        710        720
AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD SLMCEKRIFE TVNSVRHPFL
       730        740        750        760        770        780
VNLFACFQTK EHVCFVMEYA AGGDLMMHIH TDVFSEPRAV FYAACVVLGL QYLHEHKIVY
       790        800        810        820        830        840
RDLKLDNLLL DTEGFVKIAD FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW
       850        860        870        880        890        900
WGLGVLIYEM LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL
       910        920        930        940        950        960
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF TSEAPILTPP
       970        980
REPRILSEEE QEMFRDFDYI ADWC         10         20         30         40         50         60
MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RIKREIRKEL
        70         80         90        100        110        120
KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDITDCPR
       130        140        150        160        170        180
TPDTPNNDPR CSTSNNRLKA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL
       190        200        210        220        230        240
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM
       250        260        270        280        290        300
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA
       310        320        330        340        350        360
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK ATSVALPGWS
       370        380        390        400        410        420
PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD NTVVGQTSWK PISNQSWDQK
       430        440        450        460        470        480
FTLELDRSRE LEISVYWRDW RSLCAVKFLR LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN
       490        500        510        520        530        540
PVIERRPKLQ RQKKIFSKQQ GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV
       550        560        570        580        590        600
PTTVPVVDVR IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG
       610        620        630        640        650        660
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF QFNLQDFRCC
       670        680        690        700        710        720
AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD SLMCEKRIFE TVNSVRHPFL
       730        740        750        760        770        780
VNLFACFQTK EHVCFVMEYA AGGDLMMHIH TDVFSEPRAV FYAACVVLGL QYLHEHKIVY
       790        800        810        820        830        840
RDLKLDNLLL DTEGFVKIAD FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW
       850        860        870        880        890        900
WGLGVLIYEM LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL
       910        920        930        940        950        960
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF TSEAPILTPP
       970        980
REPRILSEEE QEMFRDFDYI ADWC         10         20         30         40         50         60
MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RIKREIRKEL
        70         80         90        100        110        120
KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDITDCPR
       130        140        150        160        170        180
TPDTPNNDPR CSTSNNRLKA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL
       190        200        210        220        230        240
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM
       250        260        270        280        290        300
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA
       310        320        330        340        350        360
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK ATSVALPGWS
       370        380        390        400        410        420
PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD NTVVGQTSWK PISNQSWDQK
       430        440        450        460        470        480
FTLELDRSRE LEISVYWRDW RSLCAVKFLR LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN
       490        500        510        520        530        540
PVIERRPKLQ RQKKIFSKQQ GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV
       550        560        570        580        590        600
PTTVPVVDVR IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG
       610        620        630        640        650        660
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF QFNLQDFRCC
       670        680        690        700        710        720
AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD SLMCEKRIFE TVNSVRHPFL
       730        740        750        760        770        780
VNLFACFQTK EHVCFVMEYA AGGDLMMHIH TDVFSEPRAV FYAACVVLGL QYLHEHKIVY
       790        800        810        820        830        840
RDLKLDNLLL DTEGFVKIAD FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW
       850        860        870        880        890        900
WGLGVLIYEM LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL
       910        920        930        940        950        960
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF TSEAPILTPP
       970        980
REPRILSEEE QEMFRDFDYI ADWC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16513-1-unknown	MASNPE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16513-1-unknown	MASNPE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85442
Q16513-1-unknown	MASNPE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85443
Q16513-118-unknown	CPRTPD...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2236
Q16513-118-unknown	CPRTPD...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143387
Q16513-118-unknown	CPRTPD...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143388
Q16513-158-unknown	MIQMYS...	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85444
Q16513-158-unknown	MIQMYS...	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106874
Q16513-158-unknown	MIQMYS...	158	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt106875
Q16513-603-unknown	SETVFD...	603	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12392
Q16513-603-unknown	SETVFD...	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149271
Q16513-603-unknown	SETVFD...	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152738
Q16513-603-unknown	SETVFD...	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154041
Q16513-603-unknown	SETVFD...	603	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154416
Q16513-701-unknown	SLMCEK...	701	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2239
Q16513-701-unknown	SLMCEK...	701	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151514
Q16513-701-unknown	SLMCEK...	701	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153928
Q16513-701-unknown	SLMCEK...	701	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155360
Q16513-701-unknown	SLMCEK...	701	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155704

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EDITDC	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2236
...EDITDC	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126619
...EDITDC	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126620
...IPGQDS	602	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12392
...IPGQDS	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132657
...IPGQDS	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136158
...IPGQDS	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137460
...IPGQDS	602	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137837
...RDEVDS	700	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2239
...RDEVDS	700	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134918
...RDEVDS	700	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137350
...RDEVDS	700	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138793
...RDEVDS	700	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139150
...IADWC	984	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IADWC	984	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81063
...IADWC	984	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81062
...IADWC	984	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81061
...IADWC	984	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81060

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	117	ITDC.\|.CPRT	inferred from experiment	unknown	MEROPS	Chung J	Koh H et al.:Inhibition of Akt and its anti-... (C14.003)	10926925,
GRAB_HUMAN	602	GQDS.\|.SETV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	700	EVDS.\|.SLMC	inferred from experiment	unknown	MEROPS	Chung J	Koh H et al.:Inhibition of Akt and its anti-... (C14.003)	10926925,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)