Q16656: Nuclear respiratory factor 1

General Information

Protein names	- Nuclear respiratory factor 1 - NRF-1 - Alpha palindromic-binding protein - Alpha-pal
Gene names	NRF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16656

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Nuclear respiratory factor 1 - Isoform 3 of Nuclear respiratory factor 1 - Isoform 4 of Nuclear respiratory factor 1

Sequence View

        10         20         30         40         50         60
MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED TSYDDSDILN
        70         80         90        100        110        120
STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN PSIRKRQQTR LLRKLRATLD
       130        140        150        160        170        180
EYTTRVGQQA IVLCISPSKP NPVFKVFGAA PLENVVRKYK SMILEDLESA LAEHAPAPQE
       190        200        210        220        230        240
VNSELPPLTI DGIPVSVDKM TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW
       250        260        270        280        290        300
ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL
       310        320        330        340        350        360
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA VADGEVEQNW
       370        380        390        400        410        420
ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA TVTMALNSEA AAHAVATLAE
       430        440        450        460        470        480
ATLQGGGQIV LSGETAAAVG ALTGVQDANG LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV
       490        500
TTRISDSAVT MDGQAVEVVT LEQ         10         20         30         40         50         60
MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED TSYDDSDILN
        70         80         90        100        110        120
STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN PSIRKRQQTR LLRKLRATLD
       130        140        150        160        170        180
EYTTRVGQQA IVLCISPSKP NPVFKVFGAA PLENVVRKYK SMILEDLESA LAEHAPAPQE
       190        200        210        220        230        240
VNSELPPLTI DGIPVSVDKM TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW
       250        260        270        280        290        300
ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL
       310        320        330        340        350        360
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA VADGEVEQNW
       370        380        390        400        410        420
ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA TVTMALNSEA AAHAVATLAE
       430        440        450        460        470        480
ATLQGGGQIV LSGETAAAVG ALTGVQDANG LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV
       490        500
TTRISDSAVT MDGQAVEVVT LEQ         10         20         30         40         50         60
MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED TSYDDSDILN
        70         80         90        100        110        120
STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN PSIRKRQQTR LLRKLRATLD
       130        140        150        160        170        180
EYTTRVGQQA IVLCISPSKP NPVFKVFGAA PLENVVRKYK SMILEDLESA LAEHAPAPQE
       190        200        210        220        230        240
VNSELPPLTI DGIPVSVDKM TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW
       250        260        270        280        290        300
ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL
       310        320        330        340        350        360
VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA VADGEVEQNW
       370        380        390        400        410        420
ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA TVTMALNSEA AAHAVATLAE
       430        440        450        460        470        480
ATLQGGGQIV LSGETAAAVG ALTGVQDANG LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV
       490        500
TTRISDSAVT MDGQAVEVVT LEQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16656-1-unknown	MEEHGV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16656-1-unknown	MEEHGV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83258
Q16656-1-unknown	MEEHGV...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83260
Q16656-80-unknown	AAAAAV...	80	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14539
Q16656-80-unknown	AAAAAV...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141313
Q16656-80-unknown	AAAAAV...	80	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141314
Q16656-80-	AAAAAV...	80		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16656-162-unknown	MILEDL...	162	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt83259
Q16656-162-unknown	MILEDL...	162	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440455
Q16656-162-unknown	MILEDL...	162	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99177
Q16656-162-unknown	MILEDL...	162	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99178

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GPVGMA	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14539
...GPVGMA	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124478
...GPVGMA	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124479
...LRAFIP	209	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000394877
...LRAFIP	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155716
...LRAFIP	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155715
...LRAFIP	209	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155717
...VTLEQ	503	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VTLEQ	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78877
...VTLEQ	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78876
...VTLEQ	503	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78878

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	79	VGMA.\|.AAAA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)