Q16666: Gamma-interferon-inducible protein 16

General Information

Protein names	- Gamma-interferon-inducible protein 16 - Ifi-16 - Interferon-inducible myeloid differentiation transcriptional activator
Gene names	IFI16
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16666

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Gamma-interferon-inducible protein 16 - Isoform 3 of Gamma-interferon-inducible protein 16 - Isoform 4 of Gamma-interferon-inducible protein 16

Sequence View

        10         20         30         40         50         60
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA
        70         80         90        100        110        120
GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA
       130        140        150        160        170        180
EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS
       190        200        210        220        230        240
STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF
       250        260        270        280        290        300
HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
       310        320        330        340        350        360
TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD
       370        380        390        400        410        420
KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK SMKLPQEQRQ LPYPSEASTT
       430        440        450        460        470        480
FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS KMNDFMRMQI LKEGSHFPGP FMTSIGPAES
       490        500        510        520        530        540
HPHTPQMPPS TPSSSFLTTK SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT
       550        560        570        580        590        600
PQMPPSTPSS SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF
       610        620        630        640        650        660
HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV ADVNADRNME
       670        680        690        700        710        720
IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG EFTYYEIQDN TGKMEVVVHG
       730        740        750        760        770        780
RLTTINCEEG DKLKLTCFEL APKSGNTGEL RSVIHSHIKV IKTRKNKKDI LNPDSSMETS

PDFFF         10         20         30         40         50         60
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA
        70         80         90        100        110        120
GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA
       130        140        150        160        170        180
EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS
       190        200        210        220        230        240
STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF
       250        260        270        280        290        300
HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
       310        320        330        340        350        360
TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD
       370        380        390        400        410        420
KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK SMKLPQEQRQ LPYPSEASTT
       430        440        450        460        470        480
FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS KMNDFMRMQI LKEGSHFPGP FMTSIGPAES
       490        500        510        520        530        540
HPHTPQMPPS TPSSSFLTTK SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT
       550        560        570        580        590        600
PQMPPSTPSS SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF
       610        620        630        640        650        660
HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV ADVNADRNME
       670        680        690        700        710        720
IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG EFTYYEIQDN TGKMEVVVHG
       730        740        750        760        770        780
RLTTINCEEG DKLKLTCFEL APKSGNTGEL RSVIHSHIKV IKTRKNKKDI LNPDSSMETS

PDFFF         10         20         30         40         50         60
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA
        70         80         90        100        110        120
GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA
       130        140        150        160        170        180
EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS
       190        200        210        220        230        240
STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF
       250        260        270        280        290        300
HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
       310        320        330        340        350        360
TLKIDILHKQ ASGNIVYGVF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD
       370        380        390        400        410        420
KLQLFCFRLR KKNQMSKLIS EMHSFIQIKK KTNPRNNDPK SMKLPQEQRQ LPYPSEASTT
       430        440        450        460        470        480
FPESHLRTPQ MPPTTPSSSF FTKKSEDTIS KMNDFMRMQI LKEGSHFPGP FMTSIGPAES
       490        500        510        520        530        540
HPHTPQMPPS TPSSSFLTTK SEDTISKMND FMRMQILKEG SHFPGPFMTS IGPAESHPHT
       550        560        570        580        590        600
PQMPPSTPSS SFLTTLKPRL KTEPEEVSIE DSAQSDLKEV MVLNATESFV YEPKEQKKMF
       610        620        630        640        650        660
HATVATENEV FRVKVFNIDL KEKFTPKKII AIANYVCRNG FLEVYPFTLV ADVNADRNME
       670        680        690        700        710        720
IPKGLIRSAS VTPKINQLCS QTKGSFVNGV FEVHKKNVRG EFTYYEIQDN TGKMEVVVHG
       730        740        750        760        770        780
RLTTINCEEG DKLKLTCFEL APKSGNTGEL RSVIHSHIKV IKTRKNKKDI LNPDSSMETS

PDFFF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16666-1-unknown	MGKKYK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16666-1-unknown	MGKKYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77522
Q16666-1-unknown	MGKKYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77523
Q16666-1-unknown	MGKKYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77524
Q16666-775-unknown	SSMETS...	775	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12402
Q16666-775-unknown	SSMETS...	775	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155451
Q16666-775-unknown	SSMETS...	775	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156028
Q16666-775-unknown	SSMETS...	775	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156029

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ILNPDS	774	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12402
...ILNPDS	774	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138885
...ILNPDS	774	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139488
...ILNPDS	774	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139489
...PDFFF	785	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PDFFF	785	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73141
...PDFFF	785	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73140
...PDFFF	785	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73142

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	774	NPDS.\|.SSME	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)