Q2M3T9: Hyaluronidase-4

General Information

Protein names	- Hyaluronidase-4 - Hyal-4 - 3.2.1.35 - Chondroitin sulfate endo-beta-N-acetylgalactosaminidase - Chondroitin sulfate hydrolase - CSHY - Hyaluronoglucosaminidase-4
Gene names	HYAL4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q2M3T9

2 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKVLSEGQLK LCVVQPVHLT SWLLIFFILK SISCLKPARL PIYQRKPFIA AWNAPTDQCL
        70         80         90        100        110        120
IKYNLRLNLK MFPVIGSPLA KARGQNVTIF YVNRLGYYPW YTSQGVPING GLPQNISLQV
       130        140        150        160        170        180
HLEKADQDIN YYIPAEDFSG LAVIDWEYWR PQWARNWNSK DVYRQKSRKL ISDMGKNVSA
       190        200        210        220        230        240
TDIEYLAKVT FEESAKAFMK ETIKLGIKSR PKGLWGYYLY PDCHNYNVYA PNYSGSCPED
       250        260        270        280        290        300
EVLRNNELSW LWNSSAALYP SIGVWKSLGD SENILRFSKF RVHESMRIST MTSHDYALPV
       310        320        330        340        350        360
FVYTRLGYRD EPLFFLSKQD LVSTIGESAA LGAAGIVIWG DMNLTASKAN CTKVKQFVSS
       370        380        390        400        410        420
DLGSYIANVT RAAEVCSLHL CRNNGRCIRK MWNAPSYLHL NPASYHIEAS EDGEFTVKGK
       430        440        450        460        470        480
ASDTDLAVMA DTFSCHCYQG YEGADCREIK TADGCSGVSP SPGSLMTLCL LLLASYRSIQ

L

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q2M3T9-1-unknown	MKVLSE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q2M3T9-209-unknown	SRPKGL...	209		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14545

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PIYQRK	45	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417872
...CLIKYN	63	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419522
...KLGIKS	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14545
...RSIQL	481	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	208	GIKS.\|.SRPK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)