Q32P41: tRNA (guanine(37)-N1)-methyltransferase {ECO:0000255|HAMAP-Rule:MF_03152}

General Information

Protein names	- tRNA (guanine(37)-N1)-methyltransferase {ECO:0000255\|HAMAP-Rule:MF_03152} - 2.1.1.228 {ECO:0000255\|HAMAP-Rule:MF_03152} - M1G-methyltransferase {ECO:0000255\|HAMAP-Rule:MF_03152} - tRNA GM37] methyltransferase {ECO:0000255\|HAMAP-Rule:MF_03152} - tRNA methyltransferase 5 homolog {ECO:0000255\|HAMAP-Rule:MF_03152}
Gene names	TRMT5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q32P41

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLWILWRPF GFSGRFLKLE SHSITESKSL IPVAWTSLTQ MLLEAPGIFL LGQRKRFSTM
        70         80         90        100        110        120
PETETHERET ELFSPPSDVR GMTKLDRTAF KKTVNIPVLK VRKEIVSKLM RSLKRAALQR
       130        140        150        160        170        180
PGIRRVIEDP EDKESRLIML DPYKIFTHDS FEKAELSVLE QLNVSPQISK YNLELTYEHF
       190        200        210        220        230        240
KSEEILRAVL PEGQDVTSGF SRIGHIAHLN LRDHQLSFKH LIGQVMIDKN PGITSAVNKI
       250        260        270        280        290        300
NNIDNMYRNF QMEVLSGEQN MMTKVRENNY TYEFDFSKVY WNPRLSTEHS RITELLKPGD
       310        320        330        340        350        360
VLFDVFAGVG PFAIPVAKKN CTVFANDLNP ESHKWLLYNC KLNKVDQKVK VFNLDGKDFL
       370        380        390        400        410        420
QGPVKEELMQ LLGLSKERKP SVHVVMNLPA KAIEFLSAFK WLLDGQPCSS EFLPIVHCYS
       430        440        450        460        470        480
FSKDANPAED VRQRAGAVLG ISLEACSSVH LVRNVAPNKE MLCITFQIPA SVLYKNQTRN
       490        500
PENHEDPPLK RQRTAEAFSD EKTQIVSNT

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q32P41-1-unknown	MVLWIL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q32P41-58-unknown	STMPET...	58		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q32P41-58-	STMPET...	58		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q32P41-58-	STMPET...	58		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q32P41-58-	STMPET...	58		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q32P41-58-	STMPET...	58		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q32P41-58-	STMPET...	58		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...PGIRRV	125	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000451666
...LIMLDP	141	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452567
...IVSNT	509		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...IVSNT	509	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...IVSNT	509		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...IVSNT	509		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)