Q4ZIN3: Membralin

General Information

Protein names	- Membralin - Transmembrane protein 259
Gene names	TMEM259
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q4ZIN3

7 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF KMAVTYSRLF
        70         80         90        100        110        120
PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH VRDKWPREGI LRVEVRHNSS
       130        140        150        160        170        180
RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM EDEEEEELTM EMFGNSSIKF ELDIEPKVFK
       190        200        210        220        230        240
PPSSTEALND SQEFPFPETP TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD
       250        260        270        280        290        300
PTRDQCFGDR FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA
       310        320        330        340        350        360
RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA APLLTVILAL
       370        380        390        400        410        420
VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS KRHWLRFFYL YHFAFYAYHY
       430        440        450        460        470        480
RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE LPAILQQVRI QEMLLQAPPL GPGTPTALPD
       490        500        510        520        530        540
DMNNNSGAPA TAPDSAGQPP ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW
       550        560        570        580        590        600
MAETAAIITD ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA
       610        620
VGGPSPASMA PTEAPSEVGS

Isoforms

- Isoform 2 of Membralin

Sequence View

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Physiological Relevance:

Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
Q4ZIN3-1-unknown	MSEHVE...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80577
Q4ZIN3-2-unknown	MSEHVE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q4ZIN3-2-Acetylation	SEHVEP...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q4ZIN3-2-Acetylation	SEHVEP...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q4ZIN3-2-Acetylation	SEHVEP...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111502
Q4ZIN3-51-unknown	KMAVTY...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467728
Q4ZIN3-51-unknown	KMAVTY...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196150
Q4ZIN3-170-unknown	FELDIE...	170		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475672
Q4ZIN3-170-unknown	FELDIE...	170		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197815
Q4ZIN3-264-unknown	DILMSS...	264		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000475704
Q4ZIN3-264-unknown	DILMSS...	264		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt198586
Q4ZIN3-343-unknown	NMAIAF...	343		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4126
Q4ZIN3-343-unknown	NMAIAF...	343		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150797

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LGYDDI	264	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000476127
...NEENKG	280	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475354
...QMLEMN	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4126
...QMLEMN	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134199
...LGPVSP	506	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000475219
...SEVGS	620	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	342	LEMN.\|.NMAI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)