Q5JPH6: Probable glutamate--tRNA ligase, mitochondrial

General Information

Protein names	- Probable glutamate--tRNA ligase, mitochondrial - 6.1.1.17 - Glutamyl-tRNA synthetase - GluRS
Gene names	EARS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5JPH6

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAALLRRLLQ RERPSAASGR PVGRREANLG TDAGVAVRVR FAPSPTGFLH LGGLRTALYN
        70         80         90        100        110        120
YIFAKKYQGS FILRLEDTDQ TRVVPGAAEN IEDMLEWAGI PPDESPRRGG PAGPYQQSQR
       130        140        150        160        170        180
LELYAQATEA LLKTGAAYPC FCSPQRLELL KKEALRNHQT PRYDNRCRNM SQEQVAQKLA
       190        200        210        220        230        240
KDPKPAIRFR LEQVVPAFQD LVYGWNRHEV ASVEGDPVIM KSDGFPTYHL ACVVDDHHMG
       250        260        270        280        290        300
ISHVLRGSEW LVSTAKHLLL YQALGWQPPH FAHLPLLLNR DGSKLSKRQG DVFLEHFAAD
       310        320        330        340        350        360
GFLPDSLLDI ITNCGSGFAE NQMGRTLPEL ITQFNLTQVT CHSALLDLEK LPEFNRLHLQ
       370        380        390        400        410        420
RLVSNESQRR QLVGKLQVLV EEAFGCQLQN RDVLNPVYVE RILLLRQGHI CRLQDLVSPV
       430        440        450        460        470        480
YSYLWTRPAV GRAQLDAISE KVDVIAKRVL GLLERSSMSL TQDMLNGELK KLSEGLEGTK
       490        500        510        520
YSNVMKLLRM ALSGQQQGPP VAEMMLALGP KEVRERIQKV VSS

Isoforms

- Isoform 2 of Probable glutamate--tRNA ligase, mitochondrial

Sequence View

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5JPH6-30-unknown	GTDAGV...	30		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q5JPH6-30-	GTDAGV...	30		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q5JPH6-30-	GTDAGV...	30		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5JPH6-30-	GTDAGV...	30		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q5JPH6-30-	GTDAGV...	30		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q5JPH6-42-unknown	APSPTG...	42	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KVVSS	523	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)