Q5T0T0: E3 ubiquitin-protein ligase MARCH8

General Information

Protein names	- E3 ubiquitin-protein ligase MARCH8 - 2.3.2.27 - Cellular modulator of immune recognition - c-MIR - Membrane-associated RING finger protein 8 - Membrane-associated RING-CH protein VIII - MARCH-VIII - RING finger protein 178 - RING-type E3 ubiquitin transferase MARCH8 {ECO:0000305}
Gene names	MARCH8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5T0T0

2 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSMPLHQISA IPSQDAISAR VYRSKTKEKE REEQNEKTLG HFMSHSSNIS KAGSPPSASA
        70         80         90        100        110        120
PAPVSSFSRT SITPSSQDIC RICHCEGDDE SPLITPCHCT GSLHFVHQAC LQQWIKSSDT
       130        140        150        160        170        180
RCCELCKYEF IMETKLKPLR KWEKLQMTSS ERRKIMCSVT FHVIAITCVV WSLYVLIDRT
       190        200        210        220        230        240
AEEIKQGQAT GILEWPFWTK LVVVAIGFTG GLLFMYVQCK VYVQLWKRLK AYNRVIYVQN
       250        260        270        280        290
CPETSKKNIF EKSPLTEPNF ENKHGYGICH SDTNSSCCTE PEDTGAEIIH V

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase MARCH8

Sequence View

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Physiological Relevance:

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5T0T0-1-unknown	MSMPLH...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5T0T0-2-acetylation	SMPLHQ...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CEGDDE	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458929
...CEGDDE	89	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000396678
...EIIHV	291	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)