Q5TBB1: Ribonuclease H2 subunit B

General Information

Protein names	- Ribonuclease H2 subunit B - RNase H2 subunit B - Aicardi-Goutieres syndrome 2 protein - AGS2 - Deleted in lymphocytic leukemia 8 - Ribonuclease HI subunit B
Gene names	RNASEH2B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5TBB1

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAGVDCGDG VGARQHVFLV SEYLKDASKK MKNGLMFVKL VNPCSGEGAI YLFNMCLQQL
        70         80         90        100        110        120
FEVKVFKEKH HSWFINQSVQ SGGLLHFATP VDPLFLLLHY LIKADKEGKF QPLDQVVVDN
       130        140        150        160        170        180
VFPNCILLLK LPGLEKLLHH VTEEKGNPEI DNKKYYKYSK EKTLKWLEKK VNQTVAALKT
       190        200        210        220        230        240
NNVNVSSRVQ STAFFSGDQA STDKEEDYIR YAHGLISDYI PKELSDDLSK YLKLPEPSAS
       250        260        270        280        290        300
LPNPPSKKIK LSDEPVEAKE DYTKFNTKDL KTEKKNSKMT AAQKALAKVD KSGMKSIDTF
       310
FGVKNKKKIG KV

Isoforms

- Isoform 2 of Ribonuclease H2 subunit B

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5TBB1-2-unknown	MAAGVD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5TBB1-1-unknown	MAAGVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt88028
Q5TBB1-2-Acetylation	AAGVDC...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5TBB1-2-Acetylation	AAGVDC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q5TBB1-2-Acetylation	AAGVDC...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q5TBB1-2-Acetylation	AAGVDC...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q5TBB1-2-Acetylation	AAGVDC...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110166
Q5TBB1-189-unknown	VQSTAF...	189		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10348
Q5TBB1-189-unknown	VQSTAF...	189		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146215

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NVSSRV	188	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10348
...NVSSRV	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129519
...KIGKV	312	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	188	SSRV.\|.VQST	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)