Q5TC82: Roquin-1 {ECO:0000305}
Protein names | - Roquin-1 {ECO:0000305} - Roquin {ECO:0000305} - 2.3.2.27 {ECO:0000269|PubMed:26489670} - RING finger and C3H zinc finger protein 1 - RING finger and CCCH-type zinc finger domain-containing protein 1 - RING finger protein 198 |
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Gene names | RC3H1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q5TC82 |
2
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD
70 80 90 100 110 120
IELLPVNSAL LQLVGAQVPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG
130 140 150 160 170 180
LNSTTQSVLS RPMQRKLVTL VHCQLVEEEG RIRAMRAARS LGERTVTELI LQHQNPQQLS
190 200 210 220 230 240
SNLWAAVRAR GCQFLGPAMQ EEALKLVLLA LEDGSALSRK VLVLFVVQRL EPRFPQASKT
250 260 270 280 290 300
SIGHVVQLLY RASCFKVTKR DEDSSLMQLK EEFRTYEALR REHDSQIVQI AMEAGLRIAP
310 320 330 340 350 360
DQWSSLLYGD QSHKSHMQSI IDKLQTPASF AQSVQELTIA LQRTGDPANL NRLRPHLELL
370 380 390 400 410 420
ANIDPSPDAP PPTWEQLENG LVAVRTVVHG LVDYIQNHSK KGADQQQPPQ HSKYKTYMCR
430 440 450 460 470 480
DMKQRGGCPR GASCTFAHSQ EELEKFRKMN KRLVPRRPLS ASLGQLNEVG LPSAAILPDE
490 500 510 520 530 540
GAVDLPSRKP PALPNGIVST GNTVTQLIPR GTDPSYDSSL KPGKIDHLSS SAPGSPPDLL
550 560 570 580 590 600
ESVPKSISAL PVNPHSIPPR GPADLPPMPV TKPLQMVPRG SQLYPAQQTD VYYQDPRGAA
610 620 630 640 650 660
PPFEPAPYQQ GMYYTPPPQC VSRFVRPPPS APEPAPPYLD HYPPYLQERV VNSQYGTQPQ
670 680 690 700 710 720
QYPPIYPSHY DGRRVYPAPS YTREEIFRES PIPIEIPPAA VPSYVPESRE RYQQIESYYP
730 740 750 760 770 780
VAPHPTQIRP SYLREPPYSR LPPPPQPHPS LDELHRRRKE IMAQLEERKV ISPPPFAPSP
790 800 810 820 830 840
TLPPTFHPEE FLDEDLKVAG KYKGNDYSQY SPWSCDTIGS YIGTKDAKPK DVVAAGSVEM
850 860 870 880 890 900
MNVESKGMRD QRLDLQRRAA ETSDDDLIPF GDRPTVSRFG AISRTSKTIY QGAGPMQAMA
910 920 930 940 950 960
PQGAPTKSIN ISDYSPYGTH GGWGASPYSP HQNIPSQGHF SERERISMSE VASHGKPLPS
970 980 990 1000 1010 1020
AEREQLRLEL QQLNHQISQQ TQLRGLEAVS NRLVLQREAN TLAGQSQPPP PPPPKWPGMI
1030 1040 1050 1060 1070 1080
SSEQLSLELH QVEREIGKRT RELSMENQCS LDMKSKLNTS KQAENGQPEP QNKVPAEDLT
1090 1100 1110 1120 1130
LTFSDVPNGS ALTQENISLL SNKTSSLNLS EDPEGGGDNN DSQRSGVTPS SAP
Isoforms
- Isoform 2 of Roquin-1Sequence View
10 20 30 40 50 60
MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD
70 80 90 100 110 120
IELLPVNSAL LQLVGAQVPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG
130 140 150 160 170 180
LNSTTQSVLS RPMQRKLVTL VHCQLVEEEG RIRAMRAARS LGERTVTELI LQHQNPQQLS
190 200 210 220 230 240
SNLWAAVRAR GCQFLGPAMQ EEALKLVLLA LEDGSALSRK VLVLFVVQRL EPRFPQASKT
250 260 270 280 290 300
SIGHVVQLLY RASCFKVTKR DEDSSLMQLK EEFRTYEALR REHDSQIVQI AMEAGLRIAP
310 320 330 340 350 360
DQWSSLLYGD QSHKSHMQSI IDKLQTPASF AQSVQELTIA LQRTGDPANL NRLRPHLELL
370 380 390 400 410 420
ANIDPSPDAP PPTWEQLENG LVAVRTVVHG LVDYIQNHSK KGADQQQPPQ HSKYKTYMCR
430 440 450 460 470 480
DMKQRGGCPR GASCTFAHSQ EELEKFRKMN KRLVPRRPLS ASLGQLNEVG LPSAAILPDE
490 500 510 520 530 540
GAVDLPSRKP PALPNGIVST GNTVTQLIPR GTDPSYDSSL KPGKIDHLSS SAPGSPPDLL
550 560 570 580 590 600
ESVPKSISAL PVNPHSIPPR GPADLPPMPV TKPLQMVPRG SQLYPAQQTD VYYQDPRGAA
610 620 630 640 650 660
PPFEPAPYQQ GMYYTPPPQC VSRFVRPPPS APEPAPPYLD HYPPYLQERV VNSQYGTQPQ
670 680 690 700 710 720
QYPPIYPSHY DGRRVYPAPS YTREEIFRES PIPIEIPPAA VPSYVPESRE RYQQIESYYP
730 740 750 760 770 780
VAPHPTQIRP SYLREPPYSR LPPPPQPHPS LDELHRRRKE IMAQLEERKV ISPPPFAPSP
790 800 810 820 830 840
TLPPTFHPEE FLDEDLKVAG KYKGNDYSQY SPWSCDTIGS YIGTKDAKPK DVVAAGSVEM
850 860 870 880 890 900
MNVESKGMRD QRLDLQRRAA ETSDDDLIPF GDRPTVSRFG AISRTSKTIY QGAGPMQAMA
910 920 930 940 950 960
PQGAPTKSIN ISDYSPYGTH GGWGASPYSP HQNIPSQGHF SERERISMSE VASHGKPLPS
970 980 990 1000 1010 1020
AEREQLRLEL QQLNHQISQQ TQLRGLEAVS NRLVLQREAN TLAGQSQPPP PPPPKWPGMI
1030 1040 1050 1060 1070 1080
SSEQLSLELH QVEREIGKRT RELSMENQCS LDMKSKLNTS KQAENGQPEP QNKVPAEDLT
1090 1100 1110 1120 1130
LTFSDVPNGS ALTQENISLL SNKTSSLNLS EDPEGGGDNN DSQRSGVTPS SAP
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q5TC82-1-unknown | MPVQAP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q5TC82-1-unknown | MPVQAP... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt87188 | |||
Q5TC82-480-unknown | EGAVDL... | 480 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12529 | |||
Q5TC82-480-unknown | EGAVDL... | 480 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153191 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AILPDE | 479 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12529 | |||
...AILPDE | 479 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136617 | |||
...PSSAP | 1133 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...PSSAP | 1133 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82806 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 479 | LPDE.|.EGAV | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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