Q5VWQ0: Lysine-specific demethylase 9 {ECO:0000250|UniProtKB:Q80T69}
Protein names | - Lysine-specific demethylase 9 {ECO:0000250|UniProtKB:Q80T69} - KDM9 {ECO:0000250|UniProtKB:Q80T69} - 1.14.11.- {ECO:0000250|UniProtKB:Q80T69} - Round spermatid basic protein 1 |
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Gene names | RSBN1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q5VWQ0 |
10
N-termini
3
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA AQVGAVRVVR
70 80 90 100 110 120
AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR GRPSQEPPLA PPHRRRRSRQ
130 140 150 160 170 180
HPGPLPPTNA APTVPGPVEP LLLPPPPPPS LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA
190 200 210 220 230 240
AGPKHKGHKE RHKHHHHRGP DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN
250 260 270 280 290 300
GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
310 320 330 340 350 360
TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL KTGTKFSNFI
370 380 390 400 410 420
HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
430 440 450 460 470 480
YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
490 500 510 520 530 540
GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP
550 560 570 580 590 600
TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650 660
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
670 680 690 700 710 720
EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVEA TQNTESNSNM
730 740 750 760 770 780
DCGLTGKREL EVDSQCVRIK TESEEACTEI QLLTTASSSF PPASELNLQQ DQKTQPIPVL
790 800
KVESRLDSDQ QHNLQEHSTT SV
Isoforms
- Isoform 4 of Round spermatid basic protein 1 - Isoform 4 of Lysine-specific demethylase 9Sequence View
10 20 30 40 50 60
MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA AQVGAVRVVR
70 80 90 100 110 120
AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR GRPSQEPPLA PPHRRRRSRQ
130 140 150 160 170 180
HPGPLPPTNA APTVPGPVEP LLLPPPPPPS LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA
190 200 210 220 230 240
AGPKHKGHKE RHKHHHHRGP DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN
250 260 270 280 290 300
GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
310 320 330 340 350 360
TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL KTGTKFSNFI
370 380 390 400 410 420
HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
430 440 450 460 470 480
YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
490 500 510 520 530 540
GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP
550 560 570 580 590 600
TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650 660
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
670 680 690 700 710 720
EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVEA TQNTESNSNM
730 740 750 760 770 780
DCGLTGKREL EVDSQCVRIK TESEEACTEI QLLTTASSSF PPASELNLQQ DQKTQPIPVL
790 800
KVESRLDSDQ QHNLQEHSTT SV
10 20 30 40 50 60
MFISGRRTAD KWRAEERLQC PAGSARAALA RCADGGAVGP FKCVFVGEMA AQVGAVRVVR
70 80 90 100 110 120
AVAAQEEPDK EGKEKPHAGV SPRGVKRQRR SSSGGSQEKR GRPSQEPPLA PPHRRRRSRQ
130 140 150 160 170 180
HPGPLPPTNA APTVPGPVEP LLLPPPPPPS LAPAGPAVAA PLPAPSTSAL FTFSPLTVSA
190 200 210 220 230 240
AGPKHKGHKE RHKHHHHRGP DGDPSSCGTD LKHKDKQENG ERTGGVPLIK APKRETPDEN
250 260 270 280 290 300
GKTQRADDFV LKKIKKKKKK KHREDMRGRR LKMYNKEVQT VCAGLTRISK EILTQGQINS
310 320 330 340 350 360
TSGLNKESFR YLKDEQLCRL NLGMQEYRVP QGVQTPFMTH QEHSIRRNFL KTGTKFSNFI
370 380 390 400 410 420
HEEHQSNGGA LVLHAYMDEL SFLSPMEMER FSEEFLALTF SENEKNAAYY ALAIVHGAAA
430 440 450 460 470 480
YLPDFLDYFA FNFPNTPVKM EILGKKDIET TTISNFHTQV NRTYCCGTYR AGPMRQISLV
490 500 510 520 530 540
GAVDEEVGDY FPEFLDMLEE SPFLKMTLPW GTLSSLRLQC RSQSDDGPIM WVRPGEQMIP
550 560 570 580 590 600
TADMPKSPFK RRRSMNEIKN LQYLPRTSEP REVLFEDRTR AHADHVGQGF DWQSTAAVGV
610 620 630 640 650 660
LKAVQFGEWS DQPRITKDVI CFHAEDFTDV VQRLQLDLHE PPVSQCVQWV DEAKLNQMRR
670 680 690 700 710 720
EGIRYARIQL CDNDIYFIPR NVIHQFKTVS AVCSLAWHIR LKQYHPVVEA TQNTESNSNM
730 740 750 760 770 780
DCGLTGKREL EVDSQCVRIK TESEEACTEI QLLTTASSSF PPASELNLQQ DQKTQPIPVL
790 800
KVESRLDSDQ QHNLQEHSTT SV
Protein Neighborhood
Domains & Features
10 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q5VWQ0-1-unknown | MFISGR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q5VWQ0-1-unknown | MFISGR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt88267 | |||
Q5VWQ0-2-acetylation | FISGRR... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q5VWQ0-2-acetylation | FISGRR... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q5VWQ0-2-acetylation | FISGRR... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162955 | ||
Q5VWQ0-13-unknown | RAEERL... | 13 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5VWQ0-13-unknown | RAEERL... | 13 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160220 | |||
Q5VWQ0-49-unknown | MAAQVG... | 49 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q5VWQ0-49-unknown | MAAQVG... | 49 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt196104 | |||
Q5VWQ0-61- | AVAAQE... | 61 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q5VWQ0-61-unknown | AVAAQE... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169278 | |||
Q5VWQ0-124-unknown | PLPPTN... | 124 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q5VWQ0-124-unknown | PLPPTN... | 124 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160222 | |||
Q5VWQ0-172- | TFSPLT... | 172 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
Q5VWQ0-172- | TFSPLT... | 172 | Subtiligase Based Positive Selection | Wells | THP_untreated | 23264352 | |||
Q5VWQ0-172-unknown | TFSPLT... | 172 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt169280 | |||
Q5VWQ0-294-unknown | TQGQIN... | 294 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14584 | |||
Q5VWQ0-294-unknown | TQGQIN... | 294 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt149715 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SKEILT | 293 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14584 | |||
...SKEILT | 293 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt133104 | |||
...NFHTQV | 459 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt83885 | |||
...STTSV | 802 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAM_HUMAN | 293 | EILT.|.TQGQ | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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