Q5W0B1: RING finger protein 219

General Information

Protein names	- RING finger protein 219
Gene names	RNF219
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q5W0B1

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQTVQNVTL SLTLPITCHI CLGKVRQPVI CINNHVFCSI CIDLWLKNNS QCPACRVPIT
        70         80         90        100        110        120
PENPCKEIIG GTSESEPMLS HTVRKHLRKT RLELLHKEYE DEIDCLQKEV EELKSKNLSL
       130        140        150        160        170        180
ESQIKTILDP LTLVQGNQNE DKHLVTDNPS KINPETVAEW KKKLRTANEI YEKVKDDVDK
       190        200        210        220        230        240
LKEANKKLKL ENGGLVRENL RLKAEVDNRS PQKFGRFAVA ALQSKVEQYE RETNRLKKAL
       250        260        270        280        290        300
ERSDKYIEEL ESQVAQLKNS SEEKEAMNSI CQTALSADGK GSKGSEEDVV SKNQGDSARK
       310        320        330        340        350        360
QPGSSTSSSS HLAKPSSSRL CDTSSARQES TSKADLNCSK NKDLYQEQVE VMLDVTDTSM
       370        380        390        400        410        420
DTYLEREWGN KPSDCVPYKD EELYDLPAPC TPLSLSCLQL STPENRESSV VQAGGSKKHS
       430        440        450        460        470        480
NHLRKLVFDD FCDSSNVSNK DSSEDDISRS ENEKKSECFS SPKTGFWDCC STSYAQNLDF
       490        500        510        520        530        540
ESSEGNTIAN SVGEISSKLS EKSGLCLSKR LNSIRSFEMN RTRTSSEASM DAAYLDKISE
       550        560        570        580        590        600
LDSMMSESDN SKSPCNNGFK SLDLDGLSKS SQGSEFLEEP DKLEEKTELN LSKGSLTNDQ
       610        620        630        640        650        660
LENGSEWKPT SFFLLSPSDQ EMNEDFSLHS SSCPVTNEIK PPSCLFQTEF SQGILLSSSH
       670        680        690        700        710        720
RLFEDQRFGS SLFKMSSEMH SLHNHLQSPW STSFVPEKRN KNVNQSTKRK IQSSLSSASP

SKATKS

Isoforms

Sequence View

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Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q5W0B1-1-unknown	MAQTVQ...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q5W0B1-434-	SSNVSN...	434		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q5W0B1-434-	SSNVSN...	434		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q5W0B1-434-unknown	SSNVSN...	434	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2253
Q5W0B1-543-	SMMSES...	543		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DDFCDS	433	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2253
...KATKS	726	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KATKS	726		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KATKS	726		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KATKS	726		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KATKS	726		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	433	FCDS.\|.SSNV	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> RN219_HUMAN @433

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)