TopFIND 4.0

Q60710: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000305}

General Information

Protein names
- Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 {ECO:0000305}
- dNTPase {ECO:0000305}
- 3.1.5.- {ECO:0000269|PubMed:29379009}
- Interferon-gamma-inducible protein Mg11 {ECO:0000303|PubMed:7884320}
- SAM domain and HD domain-containing protein 1 {ECO:0000305}
- mSAMHD1 {ECO:0000303|PubMed:29379009}
Gene names Samhd1
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q60710

9

N-termini

7

C-termini

6

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MDSLLGCGVS AAAREPVPRY LTSQPRVSEV AMQSAPLEQP AKRPRCDGSP RTPPSTPPAT 
        70         80         90        100        110        120 
ANLSADDDFQ NTDLRTWEPE DVCSFLENRG FREKKVLDIF RDNKIAGSFL PFLDEDRLED 
       130        140        150        160        170        180 
LGVSSLEERK KMIECIQQLS QSRIDLMKVF NDPIHGHIEF HPLLIRIIDT PQFQRLRYIK 
       190        200        210        220        230        240 
QLGGGYYVFP GASHNRFEHS LGVGYLAGCL VRALAEKQPE LQISERDILC VQIAGLCHDL 
       250        260        270        280        290        300 
GHGPFSHMFD GRFIPRARPE KKWKHEQGSI EMFEHLVNSN ELKLVMKNYG LVPEEDITFI 
       310        320        330        340        350        360 
KEQIMGPPIT PVKDSLWPYK GRPATKSFLY EIVSNKRNGI DVDKWDYFAR DCHHLGIQNN 
       370        380        390        400        410        420 
FDYKRFIKFA RICEVEYKVK EDKTYIRKVK HICSREKEVG NLYDMFHTRN CLHRRAYQHK 
       430        440        450        460        470        480 
ISNLIDIMIT DAFLKADPYV EITGTAGKKF RISTAIDDME AFTKLTDNIF LEVLHSTDPQ 
       490        500        510        520        530        540 
LSEAQSILRN IECRNLYKYL GETQPKREKI RKEEYERLPQ EVAKAKPEKA PDVELKAEDF 
       550        560        570        580        590        600 
IVDVINVDYG MEDKNPIDRV HFYCKSNSKQ AVRINKEQVS QLLPEKFAEQ LIRVYCKKKD 
       610        620        630        640        650    
GKSLDAAGKH FVQWCALRDF TKPQDGDIIA PLITPLKWNN KTSSCLQEVS KVKTCLKF

Isoforms

- Isoform 2 of Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

Sequence View

        10         20         30         40         50         60 
MDSLLGCGVS AAAREPVPRY LTSQPRVSEV AMQSAPLEQP AKRPRCDGSP RTPPSTPPAT 
        70         80         90        100        110        120 
ANLSADDDFQ NTDLRTWEPE DVCSFLENRG FREKKVLDIF RDNKIAGSFL PFLDEDRLED 
       130        140        150        160        170        180 
LGVSSLEERK KMIECIQQLS QSRIDLMKVF NDPIHGHIEF HPLLIRIIDT PQFQRLRYIK 
       190        200        210        220        230        240 
QLGGGYYVFP GASHNRFEHS LGVGYLAGCL VRALAEKQPE LQISERDILC VQIAGLCHDL 
       250        260        270        280        290        300 
GHGPFSHMFD GRFIPRARPE KKWKHEQGSI EMFEHLVNSN ELKLVMKNYG LVPEEDITFI 
       310        320        330        340        350        360 
KEQIMGPPIT PVKDSLWPYK GRPATKSFLY EIVSNKRNGI DVDKWDYFAR DCHHLGIQNN 
       370        380        390        400        410        420 
FDYKRFIKFA RICEVEYKVK EDKTYIRKVK HICSREKEVG NLYDMFHTRN CLHRRAYQHK 
       430        440        450        460        470        480 
ISNLIDIMIT DAFLKADPYV EITGTAGKKF RISTAIDDME AFTKLTDNIF LEVLHSTDPQ 
       490        500        510        520        530        540 
LSEAQSILRN IECRNLYKYL GETQPKREKI RKEEYERLPQ EVAKAKPEKA PDVELKAEDF 
       550        560        570        580        590        600 
IVDVINVDYG MEDKNPIDRV HFYCKSNSKQ AVRINKEQVS QLLPEKFAEQ LIRVYCKKKD 
       610        620        630        640        650    
GKSLDAAGKH FVQWCALRDF TKPQDGDIIA PLITPLKWNN KTSSCLQEVS KVKTCLKF



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Protein Neighborhood

Domains & Features

9 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)