Q61210: Rho guanine nucleotide exchange factor 1

General Information

Protein names	- Rho guanine nucleotide exchange factor 1 - Lbc's second cousin - Lymphoid blast crisis-like 2
Gene names	Arhgef1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61210

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Rho guanine nucleotide exchange factor 1 - Isoform 3 of Rho guanine nucleotide exchange factor 1 - Isoform 4 of Rho guanine nucleotide exchange factor 1 - Isoform 5 of Rho guanine nucleotide exchange factor 1

Sequence View

        10         20         30         40         50         60
MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL
        70         80         90        100        110        120
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL
       130        140        150        160        170        180
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD
       190        200        210        220        230        240
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR
       250        260        270        280        290        300
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK
       310        320        330        340        350        360
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA
       370        380        390        400        410        420
PPESTEDNGE TESPEPGDDG EPGRSGLELE PEEPPGWREL VPPDTLLSLP KSQVKRQEVI
       430        440        450        460        470        480
SELLVTEAAH VRMLRVLHDL FYQPMADGGF FPLDELQNIF PSLDELIEVH SLFLDRLMKR
       490        500        510        520        530        540
RQESGYLIEE IGDVLLARFD GAEGSWFQKI SSRFCSRQSF ALEQLKAKQR KEPRFCAFVQ
       550        560        570        580        590        600
EAESRPRCRR LQLKDMIPTE MQRLTKYPLL LQSIGQNTEE STERGKVELA AECCREILHH
       610        620        630        640        650        660
VNQAVRDMED LLRLKDYQRR LDLTHLRQSS DPMLSEFKNL DITKKKLVHE GPLTWRVTKD
       670        680        690        700        710        720
KAIEVHVLLL DDLLLLLQRQ DERLLLKSHS RTLTPTPDGK TMLRPVLRLT SAMTREVATD
       730        740        750        760        770        780
HKAFYVIFTW DQEAQIYELV AQTSSERKNW CNLITETAGS LKVPAPASRL KPRPSPSSIR
       790        800        810        820        830        840
EPLLSSSENG TGGAEMAPAD ARTERLLNDL LPFCRPGPEG QLAATALQKV LSLKQILLST
       850        860        870        880        890        900
EEDSGAGPPR DGDGVPGGRA PGPVHTQEIE ENLLSLEVAI RQLEELEEEF CRLRPLLSQL
       910        920
GGTLSPNLAA PERSAQTGLS         10         20         30         40         50         60
MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL
        70         80         90        100        110        120
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL
       130        140        150        160        170        180
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD
       190        200        210        220        230        240
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR
       250        260        270        280        290        300
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK
       310        320        330        340        350        360
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA
       370        380        390        400        410        420
PPESTEDNGE TESPEPGDDG EPGRSGLELE PEEPPGWREL VPPDTLLSLP KSQVKRQEVI
       430        440        450        460        470        480
SELLVTEAAH VRMLRVLHDL FYQPMADGGF FPLDELQNIF PSLDELIEVH SLFLDRLMKR
       490        500        510        520        530        540
RQESGYLIEE IGDVLLARFD GAEGSWFQKI SSRFCSRQSF ALEQLKAKQR KEPRFCAFVQ
       550        560        570        580        590        600
EAESRPRCRR LQLKDMIPTE MQRLTKYPLL LQSIGQNTEE STERGKVELA AECCREILHH
       610        620        630        640        650        660
VNQAVRDMED LLRLKDYQRR LDLTHLRQSS DPMLSEFKNL DITKKKLVHE GPLTWRVTKD
       670        680        690        700        710        720
KAIEVHVLLL DDLLLLLQRQ DERLLLKSHS RTLTPTPDGK TMLRPVLRLT SAMTREVATD
       730        740        750        760        770        780
HKAFYVIFTW DQEAQIYELV AQTSSERKNW CNLITETAGS LKVPAPASRL KPRPSPSSIR
       790        800        810        820        830        840
EPLLSSSENG TGGAEMAPAD ARTERLLNDL LPFCRPGPEG QLAATALQKV LSLKQILLST
       850        860        870        880        890        900
EEDSGAGPPR DGDGVPGGRA PGPVHTQEIE ENLLSLEVAI RQLEELEEEF CRLRPLLSQL
       910        920
GGTLSPNLAA PERSAQTGLS         10         20         30         40         50         60
MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL
        70         80         90        100        110        120
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL
       130        140        150        160        170        180
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD
       190        200        210        220        230        240
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR
       250        260        270        280        290        300
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK
       310        320        330        340        350        360
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA
       370        380        390        400        410        420
PPESTEDNGE TESPEPGDDG EPGRSGLELE PEEPPGWREL VPPDTLLSLP KSQVKRQEVI
       430        440        450        460        470        480
SELLVTEAAH VRMLRVLHDL FYQPMADGGF FPLDELQNIF PSLDELIEVH SLFLDRLMKR
       490        500        510        520        530        540
RQESGYLIEE IGDVLLARFD GAEGSWFQKI SSRFCSRQSF ALEQLKAKQR KEPRFCAFVQ
       550        560        570        580        590        600
EAESRPRCRR LQLKDMIPTE MQRLTKYPLL LQSIGQNTEE STERGKVELA AECCREILHH
       610        620        630        640        650        660
VNQAVRDMED LLRLKDYQRR LDLTHLRQSS DPMLSEFKNL DITKKKLVHE GPLTWRVTKD
       670        680        690        700        710        720
KAIEVHVLLL DDLLLLLQRQ DERLLLKSHS RTLTPTPDGK TMLRPVLRLT SAMTREVATD
       730        740        750        760        770        780
HKAFYVIFTW DQEAQIYELV AQTSSERKNW CNLITETAGS LKVPAPASRL KPRPSPSSIR
       790        800        810        820        830        840
EPLLSSSENG TGGAEMAPAD ARTERLLNDL LPFCRPGPEG QLAATALQKV LSLKQILLST
       850        860        870        880        890        900
EEDSGAGPPR DGDGVPGGRA PGPVHTQEIE ENLLSLEVAI RQLEELEEEF CRLRPLLSQL
       910        920
GGTLSPNLAA PERSAQTGLS         10         20         30         40         50         60
MGEVAGGAAP GPPRSGLVSI IIGAEDEDFE NELEANSEDQ NSQFQSLEQV KRRPAHLMAL
        70         80         90        100        110        120
LQHVALQFEP GPLLCCLHAD MLSSLGPKEA KKAFLDFYHS FLEKTAVLRV PVPPSVAFEL
       130        140        150        160        170        180
DRTRPDLISE DVQRRFIQEV VQSQQAAVSR QLEDFRSKRL MGMTPWEQEL SLLEPWIGKD
       190        200        210        220        230        240
RGNYEARERH VAERLLSHLE ETQHTISTDE EKSAAVVTAI SLYMRHLGVR TKSGDKKSGR
       250        260        270        280        290        300
NFFRKKVMGN RRSDEPPKTK KGLSSILDPA RWNRGEPSAP DCRHLKVEAD AEKPGPADRK
       310        320        330        340        350        360
GGLGMSSRDR TVGTPGQDNP GVSLHPLSTD SVDSREPGVD TPQEPGDTPP QGPTSLEPLA
       370        380        390        400        410        420
PPESTEDNGE TESPEPGDDG EPGRSGLELE PEEPPGWREL VPPDTLLSLP KSQVKRQEVI
       430        440        450        460        470        480
SELLVTEAAH VRMLRVLHDL FYQPMADGGF FPLDELQNIF PSLDELIEVH SLFLDRLMKR
       490        500        510        520        530        540
RQESGYLIEE IGDVLLARFD GAEGSWFQKI SSRFCSRQSF ALEQLKAKQR KEPRFCAFVQ
       550        560        570        580        590        600
EAESRPRCRR LQLKDMIPTE MQRLTKYPLL LQSIGQNTEE STERGKVELA AECCREILHH
       610        620        630        640        650        660
VNQAVRDMED LLRLKDYQRR LDLTHLRQSS DPMLSEFKNL DITKKKLVHE GPLTWRVTKD
       670        680        690        700        710        720
KAIEVHVLLL DDLLLLLQRQ DERLLLKSHS RTLTPTPDGK TMLRPVLRLT SAMTREVATD
       730        740        750        760        770        780
HKAFYVIFTW DQEAQIYELV AQTSSERKNW CNLITETAGS LKVPAPASRL KPRPSPSSIR
       790        800        810        820        830        840
EPLLSSSENG TGGAEMAPAD ARTERLLNDL LPFCRPGPEG QLAATALQKV LSLKQILLST
       850        860        870        880        890        900
EEDSGAGPPR DGDGVPGGRA PGPVHTQEIE ENLLSLEVAI RQLEELEEEF CRLRPLLSQL
       910        920
GGTLSPNLAA PERSAQTGLS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q61210-1-unknown	MGEVAG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61210-1-unknown	MGEVAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67376
Q61210-1-unknown	MGEVAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67377
Q61210-1-unknown	MGEVAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67378
Q61210-1-unknown	MGEVAG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt67379
Q61210-140-unknown	VVQSQQ...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30485
Q61210-140-unknown	VVQSQQ...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144275
Q61210-140-unknown	VVQSQQ...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144277
Q61210-140-unknown	VVQSQQ...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144278
Q61210-140-unknown	VVQSQQ...	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144279
Q61210-291-unknown	AEKPGP...	291	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32457
Q61210-291-unknown	AEKPGP...	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149621
Q61210-291-unknown	AEKPGP...	291	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149622
Q61210-407-unknown	LSLPKS...	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30490
Q61210-407-unknown	LSLPKS...	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152079
Q61210-407-unknown	LSLPKS...	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152098
Q61210-407-unknown	LSLPKS...	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152099
Q61210-407-unknown	LSLPKS...	407	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152987

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RFIQEV	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30485
...RFIQEV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127534
...RFIQEV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127536
...RFIQEV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127537
...RFIQEV	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127538
...KVEADA	290	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32457
...KVEADA	290	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133008
...KVEADA	290	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133009
...PPDTLL	406	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30490
...PPDTLL	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135488
...PPDTLL	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135507
...PPDTLL	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135508
...PPDTLL	406	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136413
...QTGLS	920	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QTGLS	920	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62994
...QTGLS	920	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62997

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	139	IQEV.\|.VVQS	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ARHG1_MOUSE @139
GRAB_MOUSE	290	EADA.\|.AEKP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATE_MOUSE	406	DTLL.\|.LSLP	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> ARHG1_MOUSE @406

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)