Q61216: Double-strand break repair protein MRE11

General Information

Protein names	- Double-strand break repair protein MRE11 - 3.1.-.- {ECO:0000250\|UniProtKB:P49959} - Double-strand break repair protein MRE11A - MmMRE11A - Meiotic recombination 11 homolog 1 - MRE11 homolog 1 - Meiotic recombination 11 homolog A - MRE11 homolog A
Gene names	Mre11a
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q61216

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Double-strand break repair protein MRE11A - Isoform 2 of Double-strand break repair protein MRE11

Sequence View

        10         20         30         40         50         60
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP
       310        320        330        340        350        360
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK
       370        380        390        400        410        420
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK
       430        440        450        460        470        480
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE
       490        500        510        520        530        540
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA
       550        560        570        580        590        600
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI
       610        620        630        640        650        660
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA
       670        680        690        700
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR         10         20         30         40         50         60
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD
        70         80         90        100        110        120
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI
       130        140        150        160        170        180
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG
       190        200        210        220        230        240
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL
       250        260        270        280        290        300
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP
       310        320        330        340        350        360
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK
       370        380        390        400        410        420
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK
       430        440        450        460        470        480
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE
       490        500        510        520        530        540
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA
       550        560        570        580        590        600
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI
       610        620        630        640        650        660
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA
       670        680        690        700
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q61216-1-unknown	MSPTDP...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt81520
Q61216-2-unknown	MSPTDP...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q61216-2-unknown	MSPTDP...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61216-2-Acetylation	SPTDPL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q61216-2-Acetylation	SPTDPL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110881
Q61216-2-Acetylation	SPTDPL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q61216-647-unknown	DSDEDD...	647		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32460
Q61216-647-unknown	DSDEDD...	647		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154920

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TIEVDD	646	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32460
...TIEVDD	646	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138347
...RRNRR	706	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRNRR	706	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt77138

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_MOUSE	646	EVDD.\|.DSDE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)