Q66PJ3: ADP-ribosylation factor-like protein 6-interacting protein 4

General Information

Protein names	- ADP-ribosylation factor-like protein 6-interacting protein 4 - ARL-6-interacting protein 4 - Aip-4 - HSP-975 - HSVI-binding protein - SR-15 - SRp25 - SR-25 - Splicing factor SRrp37
Gene names	ARL6IP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q66PJ3

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 3 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 4 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 5 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 6 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 7 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 2 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 3 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 4 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 5 of ADP-ribosylation factor-like protein 6-interacting protein 4 - Isoform 6 of ADP-ribosylation factor-like protein 6-interacting protein 4

Sequence View

        10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P         10         20         30         40         50         60
MPRCTYQLEQ NPGFLPDGPG VHARAHCQDL SGPYGHEFAT SESLGGRVGK TRAPQSGARS
        70         80         90        100        110        120
RMERAGPAGE EGGAREGRLL PRAPGAWVLR ACAERAALEV GAASADTGVR GCGARGPAPL
       130        140        150        160        170        180
LASAGGGRAR DGTWGVRTKG SGAALPSRPA SRAAPRPEAS SPPLPLEKAR GGLSGPQGGR
       190        200        210        220        230        240
ARGAMAHVGS RKRSRSRSRS RGRGSEKRKK KSRKDTSRNC SASTSQGRKA STAPGAEASP
       250        260        270        280        290        300
SPCITERSKQ KARRRTRSSS SSSSSSSSSS SSSSSSSSSS SSDGRKKRGK YKDKRRKKKK
       310        320        330        340        350        360
KRKKLKKKGK EKAEAQQVEA LPGPSLDQWH RSAGEEEDGP VLTDEQKSRI QAMKPMTKEE
       370        380        390        400        410        420
WDARQSIIRK VVDPETGRTR LIKGDGEVLE EIVTKERHRE INKQATRGDC LAFQMRAGLL

P

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q66PJ3-1-unknown	MPRCTY...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q66PJ3-1-unknown	MPRCTY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67292
Q66PJ3-1-unknown	MPRCTY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67293
Q66PJ3-1-unknown	MPRCTY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67294
Q66PJ3-1-unknown	MPRCTY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67295
Q66PJ3-1-unknown	MPRCTY...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67296
Q66PJ3-123-unknown	SAGGGR...	123	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000391598
Q66PJ3-123-unknown	SAGGGR...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197299
Q66PJ3-123-unknown	SAGGGR...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197300
Q66PJ3-123-unknown	SAGGGR...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197301
Q66PJ3-123-unknown	SAGGGR...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197302
Q66PJ3-123-unknown	SAGGGR...	123	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197303
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67297
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000441406
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000406036
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396723
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413132
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000396365
Q66PJ3-124-unknown	AGGGRA...	124	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000350532
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108388
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108389
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108390
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108391
Q66PJ3-124-unknown	AGGGRA...	124	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108392
Q66PJ3-259-	SSSSSS...	259		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q66PJ3-259-unknown	SSSSSS...	259	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167954
Q66PJ3-259-unknown	SSSSSS...	259	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167955
Q66PJ3-259-unknown	SSSSSS...	259	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167956
Q66PJ3-259-unknown	SSSSSS...	259	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167957
Q66PJ3-325-unknown	SLDQWH...	325	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12547
Q66PJ3-325-unknown	SLDQWH...	325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146269
Q66PJ3-325-unknown	SLDQWH...	325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149087
Q66PJ3-325-unknown	SLDQWH...	325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150016
Q66PJ3-325-unknown	SLDQWH...	325	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150260

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EAQQVE	318	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442200
...ALPGPS	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12547
...ALPGPS	324	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129573
...DGPVLT	342	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000441406
...MTKEEW	360	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MTKEEW	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62915
...MTKEEW	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62913
...MTKEEW	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62911
...MTKEEW	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62910

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	324	PGPS.\|.SLDQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)