Q676U5: Autophagy-related protein 16-1

General Information

Protein names	- Autophagy-related protein 16-1 - APG16-like 1
Gene names	ATG16L1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q676U5

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Autophagy-related protein 16-1 - Isoform 3 of Autophagy-related protein 16-1 - Isoform 4 of Autophagy-related protein 16-1 - Isoform 5 of Autophagy-related protein 16-1

Sequence View

        10         20         30         40         50         60
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK
        70         80         90        100        110        120
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK
       130        140        150        160        170        180
DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL
       190        200        210        220        230        240
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI
       250        260        270        280        290        300
EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
       310        320        330        340        350        360
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG
       370        380        390        400        410        420
SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN
       430        440        450        460        470        480
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES
       490        500        510        520        530        540
IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV
       550        560        570        580        590        600
VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK

AVLWAQY         10         20         30         40         50         60
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK
        70         80         90        100        110        120
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK
       130        140        150        160        170        180
DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL
       190        200        210        220        230        240
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI
       250        260        270        280        290        300
EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
       310        320        330        340        350        360
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG
       370        380        390        400        410        420
SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN
       430        440        450        460        470        480
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES
       490        500        510        520        530        540
IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV
       550        560        570        580        590        600
VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK

AVLWAQY         10         20         30         40         50         60
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK
        70         80         90        100        110        120
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK
       130        140        150        160        170        180
DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL
       190        200        210        220        230        240
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI
       250        260        270        280        290        300
EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
       310        320        330        340        350        360
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG
       370        380        390        400        410        420
SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN
       430        440        450        460        470        480
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES
       490        500        510        520        530        540
IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV
       550        560        570        580        590        600
VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK

AVLWAQY         10         20         30         40         50         60
MSSGLRAADF PRWKRHISEQ LRRRDRLQRQ AFEEIILQYN KLLEKSDLHS VLAQKLQAEK
        70         80         90        100        110        120
HDVPNRHEIS PGHDGTWNDN QLQEMAQLRI KHQEELTELH KKRGELAQLV IDLNNQMQRK
       130        140        150        160        170        180
DREMQMNEAK IAECLQTISD LETECLDLRT KLCDLERANQ TLKDEYDALQ ITFTALEGKL
       190        200        210        220        230        240
RKTTEENQEL VTRWMAEKAQ EANRLNAENE KDSRRRQARL QKELAEAAKE PLPVEQDDDI
       250        260        270        280        290        300
EVIVDETSDH TEETSPVRAI SRAATKRLSQ PAGGLLDSIT NIFGRRSVSS FPVPQDNVDT
       310        320        330        340        350        360
HPGSGKEVRV PATALCVFDA HDGEVNAVQF SPGSRLLATG GMDRRVKLWE VFGEKCEFKG
       370        380        390        400        410        420
SLSGSNAGIT SIEFDSAGSY LLAASNDFAS RIWTVDDYRL RHTLTGHSGK VLSAKFLLDN
       430        440        450        460        470        480
ARIVSGSHDR TLKLWDLRSK VCIKTVFAGS SCNDIVCTEQ CVMSGHFDKK IRFWDIRSES
       490        500        510        520        530        540
IVREMELLGK ITALDLNPER TELLSCSRDD LLKVIDLRTN AIKQTFSAPG FKCGSDWTRV
       550        560        570        580        590        600
VFSPDGSYVA AGSAEGSLYI WSVLTGKVEK VLSKQHSSSI NAVAWSPSGS HVVSVDKGCK

AVLWAQY

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q676U5-1-unknown	MSSGLR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q676U5-1-unknown	MSSGLR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65838
Q676U5-1-unknown	MSSGLR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65839
Q676U5-1-unknown	MSSGLR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65840
Q676U5-1-unknown	MSSGLR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65841
Q676U5-238-unknown	DDIEVI...	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12553
Q676U5-238-unknown	DDIEVI...	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142056
Q676U5-238-unknown	DDIEVI...	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142058
Q676U5-238-unknown	DDIEVI...	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147984
Q676U5-238-unknown	DDIEVI...	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147985

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PVEQDD	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12553
...PVEQDD	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125239
...PVEQDD	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125241
...PVEQDD	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131347
...PVEQDD	237	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131348
...LWAQY	607	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LWAQY	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61458
...LWAQY	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61459
...LWAQY	607	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61456

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	237	EQDD.\|.DDIE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)