Q6IQ49: Replication stress response regulator SDE2 {ECO:0000305}

General Information

Protein names	- Replication stress response regulator SDE2 {ECO:0000305}
Gene names	SDE2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6IQ49

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein SDE2 homolog - Isoform 3 of Protein SDE2 homolog - Isoform 2 of Replication stress response regulator SDE2 - Isoform 3 of Replication stress response regulator SDE2

Sequence View

        10         20         30         40         50         60
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD
        70         80         90        100        110        120
TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE
       130        140        150        160        170        180
WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS
       190        200        210        220        230        240
KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS
       250        260        270        280        290        300
TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
       310        320        330        340        350        360
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE
       370        380        390        400        410        420
ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ
       430        440        450
ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K         10         20         30         40         50         60
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD
        70         80         90        100        110        120
TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE
       130        140        150        160        170        180
WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS
       190        200        210        220        230        240
KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS
       250        260        270        280        290        300
TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
       310        320        330        340        350        360
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE
       370        380        390        400        410        420
ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ
       430        440        450
ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K         10         20         30         40         50         60
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD
        70         80         90        100        110        120
TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE
       130        140        150        160        170        180
WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS
       190        200        210        220        230        240
KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS
       250        260        270        280        290        300
TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
       310        320        330        340        350        360
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE
       370        380        390        400        410        420
ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ
       430        440        450
ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K         10         20         30         40         50         60
MAEAAALVWI RGPGFGCKAV RCASGRCTVR DFIHRHCQDQ NVPVENFFVK CNGALINTSD
        70         80         90        100        110        120
TVQHGAVYSL EPRLCGGKGG FGSMLRALGA QIEKTTNREA CRDLSGRRLR DVNHEKAMAE
       130        140        150        160        170        180
WVKQQAEREA EKEQKRLERL QRKLVEPKHC FTSPDYQQQC HEMAERLEDS VLKGMQAASS
       190        200        210        220        230        240
KMVSAEISEN RKRQWPTKSQ TDRGASAGKR RCFWLGMEGL ETAEGSNSES SDDDSEEAPS
       250        260        270        280        290        300
TSGMGFHAPK IGSNGVEMAA KFPSGSQRAR VVNTDHGSPE QLQIPVTDSG RHILEDSCAE
       310        320        330        340        350        360
LGESKEHMES RMVTETEETQ EKKAESKEPI EEEPTGAGLN KDKETEERTD GERVAEVAPE
       370        380        390        400        410        420
ERENVAVAKL QESQPGNAVI DKETIDLLAF TSVAELELLG LEKLKCELMA LGLKCGGTLQ
       430        440        450
ERAARLFSVR GLAKEQIDPA LFAKPLKGKK K

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6IQ49-1-unknown	MAEAAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6IQ49-1-unknown	MAEAAA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89149
Q6IQ49-182-	MVSAEI...	182		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6IQ49-182-unknown	MVSAEI...	182	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167693
Q6IQ49-182-unknown	MVSAEI...	182	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167694
Q6IQ49-277-	GSPEQL...	277		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6IQ49-277-	GSPEQL...	277		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6IQ49-277-unknown	GSPEQL...	277	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167690
Q6IQ49-277-unknown	GSPEQL...	277	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167691

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...KGKKK	451	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KGKKK	451	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84768
...KGKKK	451	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt84767
...KGKKK	451		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)