Q6K0P9: Pyrin and HIN domain-containing protein 1

General Information

Protein names	- Pyrin and HIN domain-containing protein 1 - Interferon-inducible protein X
Gene names	PYHIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6K0P9

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pyrin and HIN domain-containing protein 1 - Isoform 3 of Pyrin and HIN domain-containing protein 1 - Isoform 4 of Pyrin and HIN domain-containing protein 1 - Isoform 5 of Pyrin and HIN domain-containing protein 1 - Isoform 6 of Pyrin and HIN domain-containing protein 1

Sequence View

        10         20         30         40         50         60
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA
        70         80         90        100        110        120
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT
       130        140        150        160        170        180
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ
       190        200        210        220        230        240
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH
       250        260        270        280        290        300
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV
       310        320        330        340        350        360
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE
       370        380        390        400        410        420
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ
       430        440        450        460        470        480
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS
       490
SDTSTNRHPA VP         10         20         30         40         50         60
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA
        70         80         90        100        110        120
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT
       130        140        150        160        170        180
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ
       190        200        210        220        230        240
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH
       250        260        270        280        290        300
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV
       310        320        330        340        350        360
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE
       370        380        390        400        410        420
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ
       430        440        450        460        470        480
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS
       490
SDTSTNRHPA VP         10         20         30         40         50         60
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA
        70         80         90        100        110        120
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT
       130        140        150        160        170        180
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ
       190        200        210        220        230        240
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH
       250        260        270        280        290        300
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV
       310        320        330        340        350        360
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE
       370        380        390        400        410        420
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ
       430        440        450        460        470        480
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS
       490
SDTSTNRHPA VP         10         20         30         40         50         60
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA
        70         80         90        100        110        120
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT
       130        140        150        160        170        180
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ
       190        200        210        220        230        240
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH
       250        260        270        280        290        300
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV
       310        320        330        340        350        360
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE
       370        380        390        400        410        420
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ
       430        440        450        460        470        480
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS
       490
SDTSTNRHPA VP         10         20         30         40         50         60
MANNYKKIVL LKGLEVINDY HFRIVKSLLS NDLKLNPKMK EEYDKIQIAD LMEEKFPGDA
        70         80         90        100        110        120
GLGKLIEFFK EIPTLGDLAE TLKREKLKVA NKIESIPVKG IIPSKKTKQK EVYPATPACT
       130        140        150        160        170        180
PSNRLTAKGA EETLGPQKRK KPSEEETGTK RSKMSKEQTR PSCSAGASTS TAMGRSPPPQ
       190        200        210        220        230        240
TSSSAPPNTS STESLKPLAN RHATASKNIF REDPIIAMVL NATKVFKYES SENEQRRMFH
       250        260        270        280        290        300
ATVATQTQFF HVKVLNINLK RKFIKKRIII ISNYSKRNSL LEVNEASSVS EAGPDQTFEV
       310        320        330        340        350        360
PKDIIRRAKK IPKINILHKQ TSGYIVYGLF MLHTKIVNRK TTIYEIQDKT GSMAVVGKGE
       370        380        390        400        410        420
CHNIPCEKGD KLRLFCFRLR KRENMSKLMS EMHSFIQIQK NTNQRSHDSR SMALPQEQSQ
       430        440        450        460        470        480
HPKPSEASTT LPESHLKTPQ MPPTTPSSSS FTKKDETHPG AQSSPANFRI TSPTVAPPLS
       490
SDTSTNRHPA VP

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6K0P9-1-unknown	MANNYK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6K0P9-1-unknown	MANNYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77593
Q6K0P9-1-unknown	MANNYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77594
Q6K0P9-1-unknown	MANNYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77595
Q6K0P9-1-unknown	MANNYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77596
Q6K0P9-1-unknown	MANNYK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77597
Q6K0P9-262-unknown	KFIKKR...	262	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14602
Q6K0P9-262-unknown	KFIKKR...	262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148517
Q6K0P9-262-unknown	KFIKKR...	262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148518
Q6K0P9-262-unknown	KFIKKR...	262	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148881

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...INLKRK	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14602
...INLKRK	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131890
...INLKRK	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131891
...INLKRK	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132259
...HPAVP	492	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HPAVP	492	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73211

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	261	LKRK.\|.KFIK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)