Q6NS38: DNA oxidative demethylase ALKBH2

General Information

Protein names	- DNA oxidative demethylase ALKBH2 - 1.14.11.33 - Alkylated DNA repair protein alkB homolog 2 - Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 - Oxy DC1
Gene names	ALKBH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6NS38

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 - Isoform 2 of DNA oxidative demethylase ALKBH2

Sequence View

        10         20         30         40         50         60
MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI
        70         80         90        100        110        120
RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL
       130        140        150        160        170        180
TYTFSGLTLS PKPWIPVLER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP
       190        200        210        220        230        240
GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV
       250        260
RKKVLAPRVN LTFRKILLTK K         10         20         30         40         50         60
MDRFLVKGAQ GGLLRKQEEQ EPTGEEPAVL GGDKESTRKR PRREAPGNGG HSAGPSWRHI
        70         80         90        100        110        120
RAEGLDCSYT VLFGKAEADE IFQELEKEVE YFTGALARVQ VFGKWHSVPR KQATYGDAGL
       130        140        150        160        170        180
TYTFSGLTLS PKPWIPVLER IRDHVSGVTG QTFNFVLINR YKDGCDHIGE HRDDERELAP
       190        200        210        220        230        240
GSPIASVSFG ACRDFVFRHK DSRGKSPSRR VAVVRLPLAH GSLLMMNHPT NTHWYHSLPV
       250        260
RKKVLAPRVN LTFRKILLTK K

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6NS38-1-unknown	MDRFLV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6NS38-1-unknown	MDRFLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66743
Q6NS38-4-unknown	FLVKGA...	4	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10360
Q6NS38-4-unknown	FLVKGA...	4	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194607

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLTKK	261	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LLTKK	261		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LLTKK	261		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	3	MDRF.\|.FLVK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)