Q6NWY9: Pre-mRNA-processing factor 40 homolog B

General Information

Protein names	- Pre-mRNA-processing factor 40 homolog B - Huntingtin yeast partner C - Huntingtin-interacting protein C
Gene names	PRPF40B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6NWY9

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Pre-mRNA-processing factor 40 homolog B - Isoform 3 of Pre-mRNA-processing factor 40 homolog B - Isoform 4 of Pre-mRNA-processing factor 40 homolog B

Sequence View

        10         20         30         40         50         60
MMPPPFMPPP GIPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP PLTQIPGMVP
        70         80         90        100        110        120
PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE HVAPDGRIYY YNADDKQSVW
       130        140        150        160        170        180
EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY YYNNQSKESR WTRPKDLDDL EVLVKQEAAG
       190        200        210        220        230        240
KQQQQLPQTL QPQPPQPQPD PPPVPPGPTP VPTGLLEPEP GGSEDCDVLE ATQPLEQGFL
       250        260        270        280        290        300
QQLEEGPSSS GQHQPQQEEE ESKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ
       310        320        330        340        350        360
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL QHFLEQHERM
       370        380        390        400        410        420
TSTTRYRRAE QTFGELEVWA VVPERDRKEV YDDVLFFLAK KEKEQAKQLR RRNIQALKSI
       430        440        450        460        470        480
LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDH QLQNMDKEDA LICFEEHIRA LEREEEEERE
       490        500        510        520        530        540
RARLRERRQQ RKNREAFQTF LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP
       550        560        570        580        590        600
LDLFKFYVEE LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI
       610        620        630        640        650        660
KLTFNSLLEK AEAREREREK EEARRMRRRE AAFRSMLRQA VPALELGTAW EEVRERFVCD
       670        680        690        700        710        720
SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR KGKKHHHKRS HSPSGSESEE
       730        740        750        760        770        780
EELPPPSLRP PKRRRRNPSE SGSEPSSSLD SVESGGAALG GRGSPSSHLL GADHGLRKAK
       790        800        810        820        830        840
KPKKKTKKRR HKSNSPESET DPEEKAGKES DEKEQEQDKD RELQQAELPN RSPGFGIKKE
       850        860        870
KTGWDTSESE LSEGELERRR RTLLQQLDDH Q         10         20         30         40         50         60
MMPPPFMPPP GIPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP PLTQIPGMVP
        70         80         90        100        110        120
PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE HVAPDGRIYY YNADDKQSVW
       130        140        150        160        170        180
EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY YYNNQSKESR WTRPKDLDDL EVLVKQEAAG
       190        200        210        220        230        240
KQQQQLPQTL QPQPPQPQPD PPPVPPGPTP VPTGLLEPEP GGSEDCDVLE ATQPLEQGFL
       250        260        270        280        290        300
QQLEEGPSSS GQHQPQQEEE ESKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ
       310        320        330        340        350        360
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL QHFLEQHERM
       370        380        390        400        410        420
TSTTRYRRAE QTFGELEVWA VVPERDRKEV YDDVLFFLAK KEKEQAKQLR RRNIQALKSI
       430        440        450        460        470        480
LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDH QLQNMDKEDA LICFEEHIRA LEREEEEERE
       490        500        510        520        530        540
RARLRERRQQ RKNREAFQTF LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP
       550        560        570        580        590        600
LDLFKFYVEE LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI
       610        620        630        640        650        660
KLTFNSLLEK AEAREREREK EEARRMRRRE AAFRSMLRQA VPALELGTAW EEVRERFVCD
       670        680        690        700        710        720
SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR KGKKHHHKRS HSPSGSESEE
       730        740        750        760        770        780
EELPPPSLRP PKRRRRNPSE SGSEPSSSLD SVESGGAALG GRGSPSSHLL GADHGLRKAK
       790        800        810        820        830        840
KPKKKTKKRR HKSNSPESET DPEEKAGKES DEKEQEQDKD RELQQAELPN RSPGFGIKKE
       850        860        870
KTGWDTSESE LSEGELERRR RTLLQQLDDH Q         10         20         30         40         50         60
MMPPPFMPPP GIPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP PLTQIPGMVP
        70         80         90        100        110        120
PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE HVAPDGRIYY YNADDKQSVW
       130        140        150        160        170        180
EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY YYNNQSKESR WTRPKDLDDL EVLVKQEAAG
       190        200        210        220        230        240
KQQQQLPQTL QPQPPQPQPD PPPVPPGPTP VPTGLLEPEP GGSEDCDVLE ATQPLEQGFL
       250        260        270        280        290        300
QQLEEGPSSS GQHQPQQEEE ESKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ
       310        320        330        340        350        360
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL QHFLEQHERM
       370        380        390        400        410        420
TSTTRYRRAE QTFGELEVWA VVPERDRKEV YDDVLFFLAK KEKEQAKQLR RRNIQALKSI
       430        440        450        460        470        480
LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDH QLQNMDKEDA LICFEEHIRA LEREEEEERE
       490        500        510        520        530        540
RARLRERRQQ RKNREAFQTF LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP
       550        560        570        580        590        600
LDLFKFYVEE LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI
       610        620        630        640        650        660
KLTFNSLLEK AEAREREREK EEARRMRRRE AAFRSMLRQA VPALELGTAW EEVRERFVCD
       670        680        690        700        710        720
SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR KGKKHHHKRS HSPSGSESEE
       730        740        750        760        770        780
EELPPPSLRP PKRRRRNPSE SGSEPSSSLD SVESGGAALG GRGSPSSHLL GADHGLRKAK
       790        800        810        820        830        840
KPKKKTKKRR HKSNSPESET DPEEKAGKES DEKEQEQDKD RELQQAELPN RSPGFGIKKE
       850        860        870
KTGWDTSESE LSEGELERRR RTLLQQLDDH Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6NWY9-1-unknown	MMPPPF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6NWY9-1-unknown	MMPPPF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86074
Q6NWY9-7-unknown	MPPPGI...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt86073
Q6NWY9-7-unknown	MPPPGI...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99077
Q6NWY9-7-unknown	MPPPGI...	7	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt99078
Q6NWY9-606-unknown	SLLEKA...	606	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12583
Q6NWY9-606-unknown	SLLEKA...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154501
Q6NWY9-606-unknown	SLLEKA...	606	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154655
Q6NWY9-751-unknown	SVESGG...	751	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175968
Q6NWY9-751-unknown	SVESGG...	751	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175967
Q6NWY9-751-	SVESGG...	751		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLTFNS	605	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12583
...KLTFNS	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137923
...KLTFNS	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138080
...LDDHQ	871	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LDDHQ	871	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81691
...LDDHQ	871	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81692

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	605	TFNS.\|.SLLE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)