Q6P2H3: Centrosomal protein of 85 kDa

General Information

Protein names	- Centrosomal protein of 85 kDa - Cep85 - Coiled-coil domain-containing protein 21
Gene names	CEP85
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6P2H3

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Centrosomal protein of 85 kDa - Isoform 3 of Centrosomal protein of 85 kDa - Isoform 4 of Centrosomal protein of 85 kDa

Sequence View

        10         20         30         40         50         60
MAMQEKYPTE GISHVTSPSS DVIQKGSSLG TEWQTPVISE PFRSRFSRCS SVADSGDTAI
        70         80         90        100        110        120
GTSCSDIAED FCSSSGSPPF QPIKSHVTIP TAHVMPSTLG TSPAKPNSTP VGPSSSKLPL
       130        140        150        160        170        180
SGLAESVGMT RNGDLGAMKH SPGLSRDLMY FSGATGENGI EQSWFPAVGH ERQEEARKFD
       190        200        210        220        230        240
IPSMESTLNQ SAMMETLYSD PHHRVRFHNP RTSTSKELYR VLPEAKKAPG SGAVFERNGP
       250        260        270        280        290        300
HSNSSGVLPL GLQPAPGLSK PLPSQVWQPS PDTWHPREQS CELSTCRQQL ELIRLQMEQM
       310        320        330        340        350        360
QLQNGAICHH PAAFGPSLPI LEPAQWISIL NSNEHLLKEK ELLIDKQRKH ISQLEQKVRE
       370        380        390        400        410        420
SELQVHSALL GRPAPFGDVC LLRLQELQRE NTFLRAQFAQ KTEALSREKI DLEKKLSASE
       430        440        450        460        470        480
VEVQLIRESL KVALQKHSEE VKKQEERVKG RDKHINNLKK KCQKESEQNR EKQQRIETLE
       490        500        510        520        530        540
RYLADLPTLE DHQKQSQQLK DSELKSTELQ EKVTELESLL EETQAICREK EIQLESLRQR
       550        560        570        580        590        600
EAEFSSAGHS LQDKQSVEET SGEGPEVEME SWQKRYDSLQ KIVEKQQQKM DQLRSQVQSL
       610        620        630        640        650        660
EQEVAQEEGT SQALREEAQR RDSALQQLRT AVKELSVQNQ DLIEKNLTLQ EHLRQAQPGS
       670        680        690        700        710        720
PPSPDTAQLA LELHQELASC LQDLQAVCSI VTQRAQGHDP NLSLLLGIHS AQHPETQLDL
       730        740        750        760
QKPDVIKRKL EEVQQLRRDI EDLRTTMSDR YAQDMGENCV TQ         10         20         30         40         50         60
MAMQEKYPTE GISHVTSPSS DVIQKGSSLG TEWQTPVISE PFRSRFSRCS SVADSGDTAI
        70         80         90        100        110        120
GTSCSDIAED FCSSSGSPPF QPIKSHVTIP TAHVMPSTLG TSPAKPNSTP VGPSSSKLPL
       130        140        150        160        170        180
SGLAESVGMT RNGDLGAMKH SPGLSRDLMY FSGATGENGI EQSWFPAVGH ERQEEARKFD
       190        200        210        220        230        240
IPSMESTLNQ SAMMETLYSD PHHRVRFHNP RTSTSKELYR VLPEAKKAPG SGAVFERNGP
       250        260        270        280        290        300
HSNSSGVLPL GLQPAPGLSK PLPSQVWQPS PDTWHPREQS CELSTCRQQL ELIRLQMEQM
       310        320        330        340        350        360
QLQNGAICHH PAAFGPSLPI LEPAQWISIL NSNEHLLKEK ELLIDKQRKH ISQLEQKVRE
       370        380        390        400        410        420
SELQVHSALL GRPAPFGDVC LLRLQELQRE NTFLRAQFAQ KTEALSREKI DLEKKLSASE
       430        440        450        460        470        480
VEVQLIRESL KVALQKHSEE VKKQEERVKG RDKHINNLKK KCQKESEQNR EKQQRIETLE
       490        500        510        520        530        540
RYLADLPTLE DHQKQSQQLK DSELKSTELQ EKVTELESLL EETQAICREK EIQLESLRQR
       550        560        570        580        590        600
EAEFSSAGHS LQDKQSVEET SGEGPEVEME SWQKRYDSLQ KIVEKQQQKM DQLRSQVQSL
       610        620        630        640        650        660
EQEVAQEEGT SQALREEAQR RDSALQQLRT AVKELSVQNQ DLIEKNLTLQ EHLRQAQPGS
       670        680        690        700        710        720
PPSPDTAQLA LELHQELASC LQDLQAVCSI VTQRAQGHDP NLSLLLGIHS AQHPETQLDL
       730        740        750        760
QKPDVIKRKL EEVQQLRRDI EDLRTTMSDR YAQDMGENCV TQ         10         20         30         40         50         60
MAMQEKYPTE GISHVTSPSS DVIQKGSSLG TEWQTPVISE PFRSRFSRCS SVADSGDTAI
        70         80         90        100        110        120
GTSCSDIAED FCSSSGSPPF QPIKSHVTIP TAHVMPSTLG TSPAKPNSTP VGPSSSKLPL
       130        140        150        160        170        180
SGLAESVGMT RNGDLGAMKH SPGLSRDLMY FSGATGENGI EQSWFPAVGH ERQEEARKFD
       190        200        210        220        230        240
IPSMESTLNQ SAMMETLYSD PHHRVRFHNP RTSTSKELYR VLPEAKKAPG SGAVFERNGP
       250        260        270        280        290        300
HSNSSGVLPL GLQPAPGLSK PLPSQVWQPS PDTWHPREQS CELSTCRQQL ELIRLQMEQM
       310        320        330        340        350        360
QLQNGAICHH PAAFGPSLPI LEPAQWISIL NSNEHLLKEK ELLIDKQRKH ISQLEQKVRE
       370        380        390        400        410        420
SELQVHSALL GRPAPFGDVC LLRLQELQRE NTFLRAQFAQ KTEALSREKI DLEKKLSASE
       430        440        450        460        470        480
VEVQLIRESL KVALQKHSEE VKKQEERVKG RDKHINNLKK KCQKESEQNR EKQQRIETLE
       490        500        510        520        530        540
RYLADLPTLE DHQKQSQQLK DSELKSTELQ EKVTELESLL EETQAICREK EIQLESLRQR
       550        560        570        580        590        600
EAEFSSAGHS LQDKQSVEET SGEGPEVEME SWQKRYDSLQ KIVEKQQQKM DQLRSQVQSL
       610        620        630        640        650        660
EQEVAQEEGT SQALREEAQR RDSALQQLRT AVKELSVQNQ DLIEKNLTLQ EHLRQAQPGS
       670        680        690        700        710        720
PPSPDTAQLA LELHQELASC LQDLQAVCSI VTQRAQGHDP NLSLLLGIHS AQHPETQLDL
       730        740        750        760
QKPDVIKRKL EEVQQLRRDI EDLRTTMSDR YAQDMGENCV TQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q6P2H3-1-unknown	MAMQEK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q6P2H3-1-unknown	MAMQEK...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70369
Q6P2H3-121-unknown	SGLAES...	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14616
Q6P2H3-121-unknown	SGLAES...	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143503
Q6P2H3-569-unknown	MESWQK...	569	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70370
Q6P2H3-569-unknown	MESWQK...	569	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt108464

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SKLPLS	120	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14616
...SKLPLS	120	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt126743
...NCVTQ	762		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NCVTQ	762	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...NCVTQ	762	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65988
...NCVTQ	762	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt65987
...NCVTQ	762		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	120	LPLS.\|.SGLA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)