Q6UN15: Pre-mRNA 3'-end-processing factor FIP1
Protein names | - Pre-mRNA 3'-end-processing factor FIP1 - hFip1 - FIP1-like 1 protein - Factor interacting with PAP - Rearranged in hypereosinophilia |
---|---|
Gene names | FIP1L1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6UN15 |
7
N-termini
5
C-termini
3
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER PEEENASANP
70 80 90 100 110 120
PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI GDIKTGAPQY GSYGTAPVNL
130 140 150 160 170 180
NIKTGGRVYG TTGTKVKGVD LDAPGSINGV PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF
190 200 210 220 230 240
NEDTWKAYCE KQKRIRMGLE VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR
250 260 270 280 290 300
TGNSEKETAL PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350 360
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD NNFSKPPPFF
370 380 390 400 410 420
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES GHSSGYDSRS
430 440 450 460 470 480
ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ WDYYARREKD RDRERDRDRE RDRDRDRERE
490 500 510 520 530 540
RTRERERERD HSPTPSVFNS DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR
550 560 570 580 590
HKSSRSNSRR RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
Isoforms
- Isoform 3 of Pre-mRNA 3'-end-processing factor FIP1 - Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1 - Isoform 5 of Pre-mRNA 3'-end-processing factor FIP1Sequence View
10 20 30 40 50 60
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER PEEENASANP
70 80 90 100 110 120
PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI GDIKTGAPQY GSYGTAPVNL
130 140 150 160 170 180
NIKTGGRVYG TTGTKVKGVD LDAPGSINGV PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF
190 200 210 220 230 240
NEDTWKAYCE KQKRIRMGLE VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR
250 260 270 280 290 300
TGNSEKETAL PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350 360
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD NNFSKPPPFF
370 380 390 400 410 420
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES GHSSGYDSRS
430 440 450 460 470 480
ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ WDYYARREKD RDRERDRDRE RDRDRDRERE
490 500 510 520 530 540
RTRERERERD HSPTPSVFNS DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR
550 560 570 580 590
HKSSRSNSRR RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
10 20 30 40 50 60
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER PEEENASANP
70 80 90 100 110 120
PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI GDIKTGAPQY GSYGTAPVNL
130 140 150 160 170 180
NIKTGGRVYG TTGTKVKGVD LDAPGSINGV PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF
190 200 210 220 230 240
NEDTWKAYCE KQKRIRMGLE VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR
250 260 270 280 290 300
TGNSEKETAL PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350 360
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD NNFSKPPPFF
370 380 390 400 410 420
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES GHSSGYDSRS
430 440 450 460 470 480
ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ WDYYARREKD RDRERDRDRE RDRDRDRERE
490 500 510 520 530 540
RTRERERERD HSPTPSVFNS DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR
550 560 570 580 590
HKSSRSNSRR RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
10 20 30 40 50 60
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER PEEENASANP
70 80 90 100 110 120
PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI GDIKTGAPQY GSYGTAPVNL
130 140 150 160 170 180
NIKTGGRVYG TTGTKVKGVD LDAPGSINGV PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF
190 200 210 220 230 240
NEDTWKAYCE KQKRIRMGLE VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR
250 260 270 280 290 300
TGNSEKETAL PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350 360
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD NNFSKPPPFF
370 380 390 400 410 420
PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP PPSLIPTIES GHSSGYDSRS
430 440 450 460 470 480
ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ WDYYARREKD RDRERDRDRE RDRDRDRERE
490 500 510 520 530 540
RTRERERERD HSPTPSVFNS DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR
550 560 570 580 590
HKSSRSNSRR RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
Protein Neighborhood
Domains & Features
7 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6UN15-1-unknown | MSAGEV... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6UN15-1-unknown | MSAGEV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75217 | |||
Q6UN15-1-unknown | MSAGEV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75218 | |||
Q6UN15-1-unknown | MSAGEV... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt75219 | |||
Q6UN15-2-acetylation | SAGEVE... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6UN15-2-acetylation | SAGEVE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162828 | ||
Q6UN15-2-acetylation | SAGEVE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162829 | ||
Q6UN15-2-acetylation | SAGEVE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162830 | ||
Q6UN15-159- | SFEDKP... | 159 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
Q6UN15-159- | SFEDKP... | 159 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q6UN15-159- | SFEDKP... | 159 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q6UN15-159-unknown | SFEDKP... | 159 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
Q6UN15-159-unknown | SFEDKP... | 159 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161528 | |||
Q6UN15-159-unknown | SFEDKP... | 159 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161529 | |||
Q6UN15-159-unknown | SFEDKP... | 159 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt161530 | |||
Q6UN15-215-unknown | DCTMEV... | 215 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12621 | |||
Q6UN15-215-unknown | DCTMEV... | 215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146567 | |||
Q6UN15-215-unknown | DCTMEV... | 215 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146568 | |||
Q6UN15-585-unknown | QESTEA... | 585 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12624 | |||
Q6UN15-585-unknown | QESTEA... | 585 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153543 | |||
Q6UN15-585-unknown | QESTEA... | 585 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154312 | |||
Q6UN15-587-unknown | STEATP... | 587 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12627 | |||
Q6UN15-587-unknown | STEATP... | 587 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153564 | |||
Q6UN15-587-unknown | STEATP... | 587 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154339 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...KITAED | 214 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12621 | |||
...KITAED | 214 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129873 | |||
...KITAED | 214 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129874 | |||
...EPAPEQ | 584 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12624 | |||
...EPAPEQ | 584 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136965 | |||
...EPAPEQ | 584 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137733 | |||
...APEQES | 586 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12627 | |||
...APEQES | 586 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt136986 | |||
...APEQES | 586 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137760 | |||
...ATPAE | 594 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, | |||
...ATPAE | 594 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ATPAE | 594 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt70835 | |||
...ATPAE | 594 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt70837 | |||
...ATPAE | 594 | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345, |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 214 | TAED.|.DCTM | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 584 | APEQ.|.QEST | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAB_HUMAN | 586 | EQES.|.STEA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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