Q6Y1H2: Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 {ECO:0000305}

General Information

Protein names	- Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 {ECO:0000305} - 4.2.1.134 {ECO:0000269\|PubMed:18554506} - 3-hydroxyacyl-CoA dehydratase 2 {ECO:0000303\|PubMed:18554506} - HACD2 {ECO:0000303\|PubMed:18554506} - Protein-tyrosine phosphatase-like member B {ECO:0000312\|HGNC:HGNC:9640}
Gene names	PTPLB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q6Y1H2

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAVAATAAA KGNGGGGGRA GAGDASGTRK KKGPGPLATA YLVIYNVVMT AGWLVIAVGL
        70         80         90        100        110        120
VRAYLAKGSY HSLYYSIEKP LKFFQTGALL EILHCAIGIV PSSVVLTSFQ VMSRVFLIWA
       130        140        150        160        170        180
VTHSVKEVQS EDSVLLFVIA WTITEIIRYS FYTFSLLNHL PYLIKWARYT LFIVLYPMGV
       190        200        210        220        230        240
SGELLTIYAA LPFVRQAGLY SISLPNKYNF SFDYYAFLIL IMISYIPIFP QLYFHMIHQR
       250
RKILSHTEEH KKFE

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q6Y1H2-2-unknown	MAAVAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6Y1H2-2-Acetylation	AAVAAT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6Y1H2-2-	AAVAAT...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6Y1H2-3-	AVAATA...	3			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q6Y1H2-3-	AVAATA...	3			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q6Y1H2-112-unknown	MSRVFL...	112		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419237

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...PNKYNF	209	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419237
	...HKKFE	254	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)