Q75N03: E3 ubiquitin-protein ligase Hakai {ECO:0000305}

General Information

Protein names	- E3 ubiquitin-protein ligase Hakai {ECO:0000305} - 2.3.2.27 {ECO:0000250\|UniProtKB:Q9JIY2} - Casitas B-lineage lymphoma-transforming sequence-like protein 1 {ECO:0000250\|UniProtKB:Q9JIY2} - c-Cbl-like protein 1 {ECO:0000250\|UniProtKB:Q9JIY2} - RING finger protein 188 - RING-type E3 ubiquitin transferase Hakai {ECO:0000305}
Gene names	CBLL1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q75N03

5 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDHTDNELQG TNSSGSLGGL DVRRRIPIKL ISKQANKAKP APRTQRTINR MPAKAPPGDE
        70         80         90        100        110        120
EGFDYNEEER YDCKGGELFA NQRRFPGHLF WDFQINILGE KDDTPVHFCD KCGLPIKIYG
       130        140        150        160        170        180
RMIPCKHVFC YDCAILHEKK GDKMCPGCSD PVQRIEQCTR GSLFMCSIVQ GCKRTYLSQR
       190        200        210        220        230        240
DLQAHINHRH MRAGKPVTRA SLENVHPPIA PPPTEIPERF IMPPDKHHMS HIPPKQHIMM
       250        260        270        280        290        300
PPPPLQHVPH EHYNQPHEDI RAPPAELSMA PPPPRSVSQE TFRISTRKHS NLITVPIQDD
       310        320        330        340        350        360
SNSGAREPPP PAPAPAHHHP EYQGQPVVSH PHHIMPPQQH YAPPPPPPPP ISHPMPHPPQ
       370        380        390        400        410        420
AAGTPHLVYS QAPPPPMTSA PPPITPPPGH IIAQMPPYMN HPPPGPPPPQ HGGPPVTAPP
       430        440        450        460        470        480
PHHYNPNSLP QFTEDQGTLS PPFTQPGGMS PGIWPAPRGP PPPPRLQGPP SQTPLPGPHH
       490
PDQTRYRPYY Q

Isoforms

- Isoform 2 of E3 ubiquitin-protein ligase Hakai

Sequence View

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Physiological Relevance:

Evidence Codes:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q75N03-1-acetylation	MDHTDN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q75N03-1-acetylation	MDHTDN...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162567
Q75N03-1-unknown	MDHTDN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q75N03-1-unknown	MDHTDN...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76730
Q75N03-51-unknown	MPAKAP...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000410615
Q75N03-268-	SMAPPP...	268			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q75N03-268-unknown	SMAPPP...	268		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt174443

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VYSQAP	372	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000410615
...VYSQAP	372	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111497
...RPYYQ	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RPYYQ	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72348

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)