Q7L266: Isoaspartyl peptidase/L-asparaginase

General Information

Protein names	- Isoaspartyl peptidase/L-asparaginase - 3.4.19.5 {ECO:0000269\|PubMed:19839645} - 3.5.1.1 {ECO:0000269\|PubMed:19839645, ECO:0000269\|PubMed:22891768, ECO:0000269\|PubMed:27106100} - Asparaginase-like protein 1 {ECO:0000303\|PubMed:19839645} - Beta-aspartyl-peptidase {ECO:0000303\|PubMed:19839645} - Isoaspartyl dipeptidase - L-asparagine amidohydrolase - Isoaspartyl peptidase/L-asparaginase alpha chain - Isoaspartyl peptidase/L-asparaginase beta chain
Gene names	ASRGL1
Organism	Homo sapiens
Protease Family
Protease ID	T02.002
Chromosome location
UniProt ID	Q7L266

6 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNPIVVVHGG GAGPISKDRK ERVHQGMVRA ATVGYGILRE GGSAVDAVEG AVVALEDDPE
        70         80         90        100        110        120
FNAGCGSVLN TNGEVEMDAS IMDGKDLSAG AVSAVQCIAN PIKLARLVME KTPHCFLTDQ
       130        140        150        160        170        180
GAAQFAAAMG VPEIPGEKLV TERNKKRLEK EKHEKGAQKT DCQKNLGTVG AVALDCKGNV
       190        200        210        220        230        240
AYATSTGGIV NKMVGRVGDS PCLGAGGYAD NDIGAVSTTG HGESILKVNL ARLTLFHIEQ
       250        260        270        280        290        300
GKTVEEAADL SLGYMKSRVK GLGGLIVVSK TGDWVAKWTS TSMPWAAAKD GKLHFGIDPD

DTTITDLP

Isoforms

- Isoform 2 of Isoaspartyl peptidase/L-asparaginase

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7L266-1-Acetylation	MNPIVV...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7L266-1-Acetylation	MNPIVV...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q7L266-129-unknown	MGVPEI...	129		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt67625
Q7L266-167-unknown	GTVGAV...	167		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168008
Q7L266-167-	GTVGAV...	167			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q7L266-167-	GTVGAV...	167			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7L266-168-	TVGAVA...	168			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7L266-168-unknown	TVGAVA...	168		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7L266-168-unknown	TVGAVA...	168		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115981

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QKNLGT	167	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QKNLGT	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91776
...ITDLP	308	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ITDLP	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63243

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)