Q86US8: Telomerase-binding protein EST1A

General Information

Protein names	- Telomerase-binding protein EST1A - 3.1.-.- - EST1-like protein A - Ever shorter telomeres 1A - Smg-6 homolog - Telomerase subunit EST1A - hSmg5/7a
Gene names	SMG6
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86US8

7 N-termini

11 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Telomerase-binding protein EST1A - Isoform 3 of Telomerase-binding protein EST1A

Sequence View

        10         20         30         40         50         60
MAEGLERVRI SASELRGILA TLAPQAGSRE NMKELKEARP RKDNRRPDLE IYKPGLSRLR
        70         80         90        100        110        120
NKPKIKEPPG SEEFKDEIVN DRDCSAVENG TQPVKDVCKE LNNQEQNGPI DPENNRGQES
       130        140        150        160        170        180
FPRTAGQEDR SLKIIKRTKK PDLQIYQPGR RLQTVSKESA SRVEEEEVLN QVEQLRVEED
       190        200        210        220        230        240
ECRGNVAKEE VANKPDRAEI EKSPGGGRVG AAKGEKGKRM GKGEGVRETH DDPARGRPGS
       250        260        270        280        290        300
AKRYSRSDKR RNRYRTRSTS SAGSNNSAEG AGLTDNGCRR RRQDRTKERP RLKKQVSVSS
       310        320        330        340        350        360
TDSLDEDRID EPDGLGPRRS SERKRHLERN WSGRGEGEQK NSAKEYRGTL RVTFDAEAMN
       370        380        390        400        410        420
KESPMVRSAR DDMDRGKPDK GLSSGGKGSE KQESKNPKQE LRGRGRGILI LPAHTTLSVN
       430        440        450        460        470        480
SAGSPESAPL GPRLLFGSGS KGSRSWGRGG TTRRLWDPNN PDQKPALKTQ TPQLHFLDTD
       490        500        510        520        530        540
DEVSPTSWGD SRQAQASYYK FQNSDNPYYY PRTPGPASQY PYTGYNPLQY PVGPTNGVYP
       550        560        570        580        590        600
GPYYPGYPTP SGQYVCSPLP TSTMSPEEVE QHMRNLQQQE LHRLLRVADN QELQLSNLLS
       610        620        630        640        650        660
RDRISPEGLE KMAQLRAELL QLYERCILLD IEFSDNQNVD QILWKNAFYQ VIEKFRQLVK
       670        680        690        700        710        720
DPNVENPEQI RNRLLELLDE GSDFFDSLLQ KLQVTYKFKL EDYMDGLAIR SKPLRKTVKY
       730        740        750        760        770        780
ALISAQRCMI CQGDIARYRE QASDTANYGK ARSWYLKAQH IAPKNGRPYN QLALLAVYTR
       790        800        810        820        830        840
RKLDAVYYYM RSLAASNPIL TAKESLMSLF EETKRKAEQM EKKQHEEFDL SPDQWRKGKK
       850        860        870        880        890        900
STFRHVGDDT TRLEIWIHPS HPRSSQGTES GKDSEQENGL GSLSPSDLNK RFILSFLHAH
       910        920        930        940        950        960
GKLFTRIGME TFPAVAEKVL KEFQVLLQHS PSPIGSTRML QLMTINMFAV HNSQLKDCFS
       970        980        990       1000       1010       1020
EECRSVIQEQ AAALGLAMFS LLVRRCTCLL KESAKAQLSS PEDQDDQDDI KVSSFVPDLK
      1030       1040       1050       1060       1070       1080
ELLPSVKVWS DWMLGYPDTW NPPPTSLDLP SHVAVDVWST LADFCNILTA VNQSEVPLYK
      1090       1100       1110       1120       1130       1140
DPDDDLTLLI LEEDRLLSGF VPLLAAPQDP CYVEKTSDKV IAADCKRVTV LKYFLEALCG
      1150       1160       1170       1180       1190       1200
QEEPLLAFKG GKYVSVAPVP DTMGKEMGSQ EGTRLEDEEE DVVIEDFEED SEAEGSGGED
      1210       1220       1230       1240       1250       1260
DIRELRAKKL ALARKIAEQQ RRQEKIQAVL EDHSQMRQME LEIRPLFLVP DTNGFIDHLA
      1270       1280       1290       1300       1310       1320
SLARLLESRK YILVVPLIVI NELDGLAKGQ ETDHRAGGYA RVVQEKARKS IEFLEQRFES
      1330       1340       1350       1360       1370       1380
RDSCLRALTS RGNELESIAF RSEDITGQLG NNDDLILSCC LHYCKDKAKD FMPASKEEPI
      1390       1400       1410
RLLREVVLLT DDRNLRVKAL TRNVPVRDIP AFLTWAQVG         10         20         30         40         50         60
MAEGLERVRI SASELRGILA TLAPQAGSRE NMKELKEARP RKDNRRPDLE IYKPGLSRLR
        70         80         90        100        110        120
NKPKIKEPPG SEEFKDEIVN DRDCSAVENG TQPVKDVCKE LNNQEQNGPI DPENNRGQES
       130        140        150        160        170        180
FPRTAGQEDR SLKIIKRTKK PDLQIYQPGR RLQTVSKESA SRVEEEEVLN QVEQLRVEED
       190        200        210        220        230        240
ECRGNVAKEE VANKPDRAEI EKSPGGGRVG AAKGEKGKRM GKGEGVRETH DDPARGRPGS
       250        260        270        280        290        300
AKRYSRSDKR RNRYRTRSTS SAGSNNSAEG AGLTDNGCRR RRQDRTKERP RLKKQVSVSS
       310        320        330        340        350        360
TDSLDEDRID EPDGLGPRRS SERKRHLERN WSGRGEGEQK NSAKEYRGTL RVTFDAEAMN
       370        380        390        400        410        420
KESPMVRSAR DDMDRGKPDK GLSSGGKGSE KQESKNPKQE LRGRGRGILI LPAHTTLSVN
       430        440        450        460        470        480
SAGSPESAPL GPRLLFGSGS KGSRSWGRGG TTRRLWDPNN PDQKPALKTQ TPQLHFLDTD
       490        500        510        520        530        540
DEVSPTSWGD SRQAQASYYK FQNSDNPYYY PRTPGPASQY PYTGYNPLQY PVGPTNGVYP
       550        560        570        580        590        600
GPYYPGYPTP SGQYVCSPLP TSTMSPEEVE QHMRNLQQQE LHRLLRVADN QELQLSNLLS
       610        620        630        640        650        660
RDRISPEGLE KMAQLRAELL QLYERCILLD IEFSDNQNVD QILWKNAFYQ VIEKFRQLVK
       670        680        690        700        710        720
DPNVENPEQI RNRLLELLDE GSDFFDSLLQ KLQVTYKFKL EDYMDGLAIR SKPLRKTVKY
       730        740        750        760        770        780
ALISAQRCMI CQGDIARYRE QASDTANYGK ARSWYLKAQH IAPKNGRPYN QLALLAVYTR
       790        800        810        820        830        840
RKLDAVYYYM RSLAASNPIL TAKESLMSLF EETKRKAEQM EKKQHEEFDL SPDQWRKGKK
       850        860        870        880        890        900
STFRHVGDDT TRLEIWIHPS HPRSSQGTES GKDSEQENGL GSLSPSDLNK RFILSFLHAH
       910        920        930        940        950        960
GKLFTRIGME TFPAVAEKVL KEFQVLLQHS PSPIGSTRML QLMTINMFAV HNSQLKDCFS
       970        980        990       1000       1010       1020
EECRSVIQEQ AAALGLAMFS LLVRRCTCLL KESAKAQLSS PEDQDDQDDI KVSSFVPDLK
      1030       1040       1050       1060       1070       1080
ELLPSVKVWS DWMLGYPDTW NPPPTSLDLP SHVAVDVWST LADFCNILTA VNQSEVPLYK
      1090       1100       1110       1120       1130       1140
DPDDDLTLLI LEEDRLLSGF VPLLAAPQDP CYVEKTSDKV IAADCKRVTV LKYFLEALCG
      1150       1160       1170       1180       1190       1200
QEEPLLAFKG GKYVSVAPVP DTMGKEMGSQ EGTRLEDEEE DVVIEDFEED SEAEGSGGED
      1210       1220       1230       1240       1250       1260
DIRELRAKKL ALARKIAEQQ RRQEKIQAVL EDHSQMRQME LEIRPLFLVP DTNGFIDHLA
      1270       1280       1290       1300       1310       1320
SLARLLESRK YILVVPLIVI NELDGLAKGQ ETDHRAGGYA RVVQEKARKS IEFLEQRFES
      1330       1340       1350       1360       1370       1380
RDSCLRALTS RGNELESIAF RSEDITGQLG NNDDLILSCC LHYCKDKAKD FMPASKEEPI
      1390       1400       1410
RLLREVVLLT DDRNLRVKAL TRNVPVRDIP AFLTWAQVG

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 11 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86US8-1-unknown	MAEGLE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86US8-32-unknown	MKELKE...	32	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443920
Q86US8-356-unknown	AEAMNK...	356	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12752
Q86US8-418-unknown	SVNSAG...	418		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86US8-418-	SVNSAG...	418		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86US8-909-unknown	METFPA...	909	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74227
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000346977
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000440283
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000459164
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460898
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000458635
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460191
Q86US8-909-unknown	METFPA...	909	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000460301
Q86US8-978-unknown	MFSLLV...	978	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000465793
Q86US8-978-unknown	MFSLLV...	978	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466139
Q86US8-978-unknown	MFSLLV...	978	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466951
Q86US8-978-unknown	MFSLLV...	978	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt200485

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RVTFDA	355	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12752
...LPSVKV	1027	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460301
...KVWSDW	1031	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460191
...NILTAV	1070	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000458635
...ILTAVN	1071	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460898
...LTAVNQ	1072	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000459164
...LLILEE	1092	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466951
...LSGFVP	1101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466139
...CYVEKT	1115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000465793
...QMELEI	1242	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000460273
...WAQVG	1419	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WAQVG	1419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69844
...WAQVG	1419	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69845

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	355	TFDA.\|.AEAM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)