TopFIND 4.0

Q86W50: RNA N6-adenosine-methyltransferase METTL16 {ECO:0000305}

General Information

Protein names
- RNA N6-adenosine-methyltransferase METTL16 {ECO:0000305}
- Methyltransferase 10 domain-containing protein {ECO:0000303|Ref.13}
- Methyltransferase-like protein 16 {ECO:0000303|PubMed:27872311}
- N6-adenosine-methyltransferase METTL16
- 2.1.1.348 {ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:30197297, ECO:0000269|PubMed:30197299}
- U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase {ECO:0000305}
- 2.1.1.346 {ECO:0000269|PubMed:28525753, ECO:0000269|PubMed:29051200}
Gene names METTL16
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q86W50

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL 
        70         80         90        100        110        120 
REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL 
       130        140        150        160        170        180 
GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF 
       190        200        210        220        230        240 
CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK 
       250        260        270        280        290        300 
RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS 
       310        320        330        340        350        360 
KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV 
       370        380        390        400        410        420 
PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ 
       430        440        450        460        470        480 
ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC 
       490        500        510        520        530        540 
QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN 
       550        560    
RDLMNQLCTY IRNQIFRLVA VN

Isoforms

- Isoform 2 of Methyltransferase-like protein 16 - Isoform 2 of RNA N6-adenosine-methyltransferase METTL16

Sequence View

        10         20         30         40         50         60 
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL 
        70         80         90        100        110        120 
REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL 
       130        140        150        160        170        180 
GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF 
       190        200        210        220        230        240 
CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK 
       250        260        270        280        290        300 
RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS 
       310        320        330        340        350        360 
KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV 
       370        380        390        400        410        420 
PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ 
       430        440        450        460        470        480 
ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC 
       490        500        510        520        530        540 
QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN 
       550        560    
RDLMNQLCTY IRNQIFRLVA VN         10         20         30         40         50         60 
MALSKSMHAR NRYKDKPPDF AYLASKYPDF KQHVQINLNG RVSLNFKDPE AVRALTCTLL 
        70         80         90        100        110        120 
REDFGLSIDI PLERLIPTVP LRLNYIHWVE DLIGHQDSDK STLRRGIDIG TGASCIYPLL 
       130        140        150        160        170        180 
GATLNGWYFL ATEVDDMCFN YAKKNVEQNN LSDLIKVVKV PQKTLLMDAL KEESEIIYDF 
       190        200        210        220        230        240 
CMCNPPFFAN QLEAKGVNSR NPRRPPPSSV NTGGITEIMA EGGELEFVKR IIHDSLQLKK 
       250        260        270        280        290        300 
RLRWYSCMLG KKCSLAPLKE ELRIQGVPKV TYTEFCQGRT MRWALAWSFY DDVTVPSPPS 
       310        320        330        340        350        360 
KRRKLEKPRK PITFVVLASV MKELSLKASP LRSETAEGIV VVTTWIEKIL TDLKVQHKRV 
       370        380        390        400        410        420 
PCGKEEVSLF LTAIENSWIH LRRKKRERVR QLREVPRAPE DVIQALEEKK PTPKESGNSQ 
       430        440        450        460        470        480 
ELARGPQERT PCGPALREGE AAAVEGPCPS QESLSQEENP EPTEDERSEE KGGVEVLESC 
       490        500        510        520        530        540 
QGSSNGAQDQ EASEQFGSPV AERGKRLPGV AGQYLFKCLI NVKKEVDDAL VEMHWVEGQN 
       550        560    
RDLMNQLCTY IRNQIFRLVA VN



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LVAVN 562 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)