Q86W56: Poly(ADP-ribose) glycohydrolase {ECO:0000303|PubMed:14527731}

General Information

Protein names	- Poly(ADP-ribose) glycohydrolase {ECO:0000303\|PubMed:14527731} - 3.2.1.143 {ECO:0000269\|PubMed:21892188, ECO:0000269\|PubMed:23481255}
Gene names	PARG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86W56

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Poly(ADP-ribose) glycohydrolase - Isoform 3 of Poly(ADP-ribose) glycohydrolase - Isoform 4 of Poly(ADP-ribose) glycohydrolase - Isoform 5 of Poly(ADP-ribose) glycohydrolase

Sequence View

        10         20         30         40         50         60
MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG
        70         80         90        100        110        120
RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ
       130        140        150        160        170        180
HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE
       190        200        210        220        230        240
QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS
       250        260        270        280        290        300
CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
       310        320        330        340        350        360
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK
       370        380        390        400        410        420
GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA
       430        440        450        460        470        480
EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH
       490        500        510        520        530        540
TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ
       550        560        570        580        590        600
TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
       610        620        630        640        650        660
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN
       670        680        690        700        710        720
FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV
       730        740        750        760        770        780
TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC
       790        800        810        820        830        840
LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK
       850        860        870        880        890        900
MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
       910        920        930        940        950        960
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV
       970
ESCAETADHS GQRTGT         10         20         30         40         50         60
MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG
        70         80         90        100        110        120
RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ
       130        140        150        160        170        180
HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE
       190        200        210        220        230        240
QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS
       250        260        270        280        290        300
CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
       310        320        330        340        350        360
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK
       370        380        390        400        410        420
GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA
       430        440        450        460        470        480
EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH
       490        500        510        520        530        540
TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ
       550        560        570        580        590        600
TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
       610        620        630        640        650        660
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN
       670        680        690        700        710        720
FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV
       730        740        750        760        770        780
TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC
       790        800        810        820        830        840
LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK
       850        860        870        880        890        900
MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
       910        920        930        940        950        960
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV
       970
ESCAETADHS GQRTGT         10         20         30         40         50         60
MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG
        70         80         90        100        110        120
RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ
       130        140        150        160        170        180
HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE
       190        200        210        220        230        240
QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS
       250        260        270        280        290        300
CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
       310        320        330        340        350        360
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK
       370        380        390        400        410        420
GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA
       430        440        450        460        470        480
EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH
       490        500        510        520        530        540
TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ
       550        560        570        580        590        600
TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
       610        620        630        640        650        660
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN
       670        680        690        700        710        720
FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV
       730        740        750        760        770        780
TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC
       790        800        810        820        830        840
LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK
       850        860        870        880        890        900
MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
       910        920        930        940        950        960
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV
       970
ESCAETADHS GQRTGT         10         20         30         40         50         60
MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG
        70         80         90        100        110        120
RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ
       130        140        150        160        170        180
HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE
       190        200        210        220        230        240
QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS
       250        260        270        280        290        300
CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP
       310        320        330        340        350        360
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK
       370        380        390        400        410        420
GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA
       430        440        450        460        470        480
EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH
       490        500        510        520        530        540
TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ
       550        560        570        580        590        600
TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI
       610        620        630        640        650        660
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN
       670        680        690        700        710        720
FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV
       730        740        750        760        770        780
TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC
       790        800        810        820        830        840
LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK
       850        860        870        880        890        900
MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF
       910        920        930        940        950        960
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV
       970
ESCAETADHS GQRTGT

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86W56-1-unknown	MNAGPG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86W56-1-acetylation	MNAGPG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86W56-83-unknown	MDTKGI...	83		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84307
Q86W56-109-unknown	MMSSVQ...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84308
Q86W56-109-unknown	MMSSVQ...	109		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100684
Q86W56-257-	VVPESP...	257			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q86W56-257-	VVPESP...	257			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86W56-257-unknown	VVPESP...	257		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2263
Q86W56-257-unknown	VVPESP...	257			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86W56-257-unknown	VVPESP...	257		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144698
Q86W56-257-unknown	VVPESP...	257		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145714
Q86W56-308-unknown	NSKNSC...	308		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2266
Q86W56-308-unknown	NSKNSC...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146579
Q86W56-308-unknown	NSKNSC...	308		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt147603
Q86W56-461-unknown	MRRMPR...	461		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt84310
Q86W56-461-unknown	MRRMPR...	461		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100805
Q86W56-461-unknown	MRRMPR...	461		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100806
Q86W56-461-unknown	MRRMPR...	461		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100807
Q86W56-486-unknown	VDLLRA...	486		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000384408
Q86W56-486-unknown	VDLLRA...	486		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131968
Q86W56-486-unknown	VDLLRA...	486		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131967

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QDEIDV	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2263
...QDEIDV	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127966
...QDEIDV	256	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129012
...PMDVDN	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2266
...PMDVDN	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129886
...PMDVDN	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130955
...QRTGT	976	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QRTGT	976	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79928
...QRTGT	976	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79927
...QRTGT	976	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79926
...QRTGT	976	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79925

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	256	EIDV.\|.VVPE	inferred from experiment	unknown	MEROPS	Poirier GG	Affar EB et al.:Caspase-3-mediated processing o... (C14.003)	11053413,
CASP3_HUMAN	307	DVDN.\|.NSKN	inferred from experiment	unknown	MEROPS	Poirier GG	Affar EB et al.:Caspase-3-mediated processing o... (C14.003)	11053413,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)