Q8C9B9: Death-inducer obliterator 1
| Protein names | - Death-inducer obliterator 1 - DIO-1 - Death-associated transcription factor 1 - DATF-1 |
|---|---|
| Gene names | Dido1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q8C9B9 |
4
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR
70 80 90 100 110 120
RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR
130 140 150 160 170 180
SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG
190 200 210 220 230 240
SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT
250 260 270 280 290 300
QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR
310 320 330 340 350 360
GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED
370 380 390 400 410 420
QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA
430 440 450 460 470 480
ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM
490 500 510 520 530 540
LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT
550 560 570 580 590 600
MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW
610 620 630 640 650 660
PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP
670 680 690 700 710 720
SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS
730 740 750 760 770 780
KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT
790 800 810 820 830 840
KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ
850 860 870 880 890 900
HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI
910 920 930 940 950 960
ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM
970 980 990 1000 1010 1020
SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR
1030 1040 1050 1060 1070 1080
YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE
1090 1100 1110 1120 1130 1140
DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR
1150 1160 1170 1180 1190 1200
FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA
1210 1220 1230 1240 1250 1260
GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS TTPPGSPPPP
1270 1280 1290 1300 1310 1320
PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA ATSKTASPLE HILQTLFGKK
1330 1340 1350 1360 1370 1380
KSFEPSGKES VGSTLSPHQD SKAKGEDTMS AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP
1390 1400 1410 1420 1430 1440
YDPEEEYNPD RAFHTLLAEP GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN
1450 1460 1470 1480 1490 1500
RMCMKVSATE RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG
1510 1520 1530 1540 1550 1560
VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR QSRDPRQARR
1570 1580 1590 1600 1610 1620
LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG PGLAAEAKES MAVPWAPGEN
1630 1640 1650 1660 1670 1680
AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT AGDGAARPAP PRRVLLPTPP STTFPPSFPL
1690 1700 1710 1720 1730 1740
QPKAQNFSSG SREPFSGPTF MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR
1750 1760 1770 1780 1790 1800
PGESTTSFPQ PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP
1810 1820 1830 1840 1850 1860
NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG APAQFEDRKD
1870 1880 1890 1900 1910 1920
PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF GGQRRPLLTQ MKGPRGGPPP
1930 1940 1950 1960 1970 1980
SQFGAQRGPP PGHFVGPRGP HPSQFENSRG THPGQFEGAR GQAPGFMPGP RGIQPQQFEE
1990 2000 2010 2020 2030 2040
QRVNSPPRFA GQRASAPLPY GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL
2050 2060 2070 2080 2090 2100
PSHPPQHRKD RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR
2110 2120 2130 2140 2150 2160
ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS RDWDRHREWD
2170 2180 2190 2200 2210 2220
KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD RDRSRSRDRD RDRERARDRD
2230 2240 2250
RDRGRDRKDR SKSRESPRDQ KPEARTSEGG PAAAQA
Isoforms
- Isoform 2 of Death-inducer obliterator 1 - Isoform 3 of Death-inducer obliterator 1Sequence View
10 20 30 40 50 60
MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR
70 80 90 100 110 120
RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR
130 140 150 160 170 180
SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG
190 200 210 220 230 240
SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT
250 260 270 280 290 300
QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR
310 320 330 340 350 360
GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED
370 380 390 400 410 420
QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA
430 440 450 460 470 480
ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM
490 500 510 520 530 540
LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT
550 560 570 580 590 600
MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW
610 620 630 640 650 660
PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP
670 680 690 700 710 720
SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS
730 740 750 760 770 780
KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT
790 800 810 820 830 840
KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ
850 860 870 880 890 900
HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI
910 920 930 940 950 960
ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM
970 980 990 1000 1010 1020
SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR
1030 1040 1050 1060 1070 1080
YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE
1090 1100 1110 1120 1130 1140
DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR
1150 1160 1170 1180 1190 1200
FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA
1210 1220 1230 1240 1250 1260
GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS TTPPGSPPPP
1270 1280 1290 1300 1310 1320
PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA ATSKTASPLE HILQTLFGKK
1330 1340 1350 1360 1370 1380
KSFEPSGKES VGSTLSPHQD SKAKGEDTMS AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP
1390 1400 1410 1420 1430 1440
YDPEEEYNPD RAFHTLLAEP GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN
1450 1460 1470 1480 1490 1500
RMCMKVSATE RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG
1510 1520 1530 1540 1550 1560
VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR QSRDPRQARR
1570 1580 1590 1600 1610 1620
LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG PGLAAEAKES MAVPWAPGEN
1630 1640 1650 1660 1670 1680
AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT AGDGAARPAP PRRVLLPTPP STTFPPSFPL
1690 1700 1710 1720 1730 1740
QPKAQNFSSG SREPFSGPTF MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR
1750 1760 1770 1780 1790 1800
PGESTTSFPQ PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP
1810 1820 1830 1840 1850 1860
NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG APAQFEDRKD
1870 1880 1890 1900 1910 1920
PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF GGQRRPLLTQ MKGPRGGPPP
1930 1940 1950 1960 1970 1980
SQFGAQRGPP PGHFVGPRGP HPSQFENSRG THPGQFEGAR GQAPGFMPGP RGIQPQQFEE
1990 2000 2010 2020 2030 2040
QRVNSPPRFA GQRASAPLPY GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL
2050 2060 2070 2080 2090 2100
PSHPPQHRKD RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR
2110 2120 2130 2140 2150 2160
ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS RDWDRHREWD
2170 2180 2190 2200 2210 2220
KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD RDRSRSRDRD RDRERARDRD
2230 2240 2250
RDRGRDRKDR SKSRESPRDQ KPEARTSEGG PAAAQA
10 20 30 40 50 60
MDDKGHLSNE EAPKAIKPTS KEFRKTWGFR RTTIAKREGA GDTEVDPSEQ QPQQHNLSLR
70 80 90 100 110 120
RSGRQPKRTE RVEEFLTTVR RRGKKNVPVS LEDSSEPTSS TVTDVETASE GSVESSSEIR
130 140 150 160 170 180
SGPVSDSLGK EHPASSEKAK GGEEEEDTSD SDSDGLTLKE LQNRLRRKRE QEPVERSLRG
190 200 210 220 230 240
SQNRLRKKRR EEDSAETGSV QIGSAEQDRP LCKQEPEASQ GPVSQSETDD IENQLEGKAT
250 260 270 280 290 300
QGNTEENPRE AGKPKPECEV YDPNALYCIC RQPHNNRFMI CCDRCEEWFH GDCVGISEAR
310 320 330 340 350 360
GRLLERNGED YICPNCTILQ VQDETNGSAT DEQDSGCRSV GADGTDCTSI GTVEQKSGED
370 380 390 400 410 420
QGIKGRIEKA ANPSGKKKLK IFQPVVEAPG APKCIGPGCS SVAQPDSVYC SNDCILKHAA
430 440 450 460 470 480
ATMRFLSSGK EQKTKPKEKV KTKPEKFSLP KCSVQVGIKI SSVHKRLASE KRENPVKKVM
490 500 510 520 530 540
LASRSETSGK EAACESSTPS WASDHNYNAV KPEKPEKPTA LSPTLLSKSM KDDRRVEDRT
550 560 570 580 590 600
MAAVTIPKKA LPSASLVGRQ TSPRNLVPKK LPPYSNMAGA KPAIKKLPSG FKGTIPKRPW
610 620 630 640 650 660
PSATLSGTSA RQAGPTPMTA ASKKLPGSAA VVGVTRKPMS ANVPAASPAP GRLGPVSPAP
670 680 690 700 710 720
SQPNSQIRQN IRRSLKEILW KRVNDSDDLI MTENEVGKIA LHIEKEMFNL FQVTDNRYKS
730 740 750 760 770 780
KYRSIMFNLK DPKNQGLFHR VLREEISLAK LVRMKPEELV SKELSMWTEK PTKSVIESRT
790 800 810 820 830 840
KLLNESKKNT TKPETIPDME DSPPVSDSEE QQESVRAAPE KSAAPLLDVF SSMLKDTTSQ
850 860 870 880 890 900
HRAHLFDLNC KICTGQVPSS EDEPAPKKQK LSASSKKEDF KPRHDSSPPN AVPNTADEGI
910 920 930 940 950 960
ADTLPENASE PDPESTSSLN QERKCFPESP GDSHPEPSSL GGLSPSSASG GSGVVTTVTM
970 980 990 1000 1010 1020
SGRDPRTALS GSCTVTASMA AHLDNSQASE TKLDMIKPAL TSAVVPKSIL AKPSSSPDPR
1030 1040 1050 1060 1070 1080
YLSVPPSPSI SESRSPPEGD TTLFLSRLNT IWKGFINMQS VAKFVTKAYP VSGCLDYLSE
1090 1100 1110 1120 1130 1140
DLPDTIHIGG RIAPKTVWDY VGKLKSSVSK ELCLIRFHPA TEEEEVAYIS LYSYFSSRGR
1150 1160 1170 1180 1190 1200
FGVVANNNRH VKDLYLIPLS AKDPVPSKLL PFEGPGLESP RPNIILGLVI CQKVKRPSSA
1210 1220 1230 1240 1250 1260
GELDKTDEKR TRLQQEELET SVYPKVTAAL PSEKKPPKYS VHSIDTAATS TTPPGSPPPP
1270 1280 1290 1300 1310 1320
PPLPEPPVLK ILSSLKPGST STVTAPTTAA ITTTASPVTA ATSKTASPLE HILQTLFGKK
1330 1340 1350 1360 1370 1380
KSFEPSGKES VGSTLSPHQD SKAKGEDTMS AAPLLDPIVQ QFGQFSKDKA LEEEEEDDRP
1390 1400 1410 1420 1430 1440
YDPEEEYNPD RAFHTLLAEP GRPHDVQSVS ETAEREEVAY DPEDETILEE AKVTIDDLPN
1450 1460 1470 1480 1490 1500
RMCMKVSATE RPADFTTDAS SASLVEQQKM LEELNKQIEE QKRQLEEQEE ALRQQRAAVG
1510 1520 1530 1540 1550 1560
VSMAHFSVSD ALMSPPPKSS LGKTELFSQE QQAPDPSQGA PNTNHNLDSR QSRDPRQARR
1570 1580 1590 1600 1610 1620
LAAENTENES LPRAPTGSTP GPQGTLPARE TPAGTAVVQG PGLAAEAKES MAVPWAPGEN
1630 1640 1650 1660 1670 1680
AVLRPEHDIQ KCEHPGNPVS LPLDTSHLPT AGDGAARPAP PRRVLLPTPP STTFPPSFPL
1690 1700 1710 1720 1730 1740
QPKAQNFSSG SREPFSGPTF MSQETSLGSS QYEDPRGAQS AGKNDSPVAD MEDSREPQPR
1750 1760 1770 1780 1790 1800
PGESTTSFPQ PGQRGGGPQP QFPGQREPAP RTFGMSGHHG PSFPGPRGPV PPYSEENLVP
1810 1820 1830 1840 1850 1860
NSDGPRGPPP ARFGAQKPPI PSLFSGQHGP PPYGDNRGLS PSYLGGPRGG APAQFEDRKD
1870 1880 1890 1900 1910 1920
PHGEKREFQD TPYNEMTGAP AQCEGPDQAQ FMGNRAPFQF GGQRRPLLTQ MKGPRGGPPP
1930 1940 1950 1960 1970 1980
SQFGAQRGPP PGHFVGPRGP HPSQFENSRG THPGQFEGAR GQAPGFMPGP RGIQPQQFEE
1990 2000 2010 2020 2030 2040
QRVNSPPRFA GQRASAPLPY GGPRGPAPFP EKNEQPPSRF HFQGPSSQPV KPPPRPLLEL
2050 2060 2070 2080 2090 2100
PSHPPQHRKD RWDEAGPATA LPSSAGPGQG HEADGQWATS EFREGKGHEY RSPAFEGRQR
2110 2120 2130 2140 2150 2160
ERFEAGSKEK PLDEPEAQGL ESRQGRAFED RRRERERGRN WSRERDWERS RDWDRHREWD
2170 2180 2190 2200 2210 2220
KGRDRSSNRD RERDNDRAKE WDRSRERSRN RDRDRERRRD RDRSRSRDRD RDRERARDRD
2230 2240 2250
RDRGRDRKDR SKSRESPRDQ KPEARTSEGG PAAAQA
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q8C9B9-1-unknown | MDDKGH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72793 | |||
| Q8C9B9-1-unknown | MDDKGH... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt72794 | |||
| Q8C9B9-1-Acetylation | MDDKGH... | 1 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
| Q8C9B9-1-Acetylation | MDDKGH... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105686 | ||
| Q8C9B9-1-Acetylation | MDDKGH... | 1 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt105687 | ||
| Q8C9B9-541-unknown | MAAVTI... | 541 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000048315 | |||
| Q8C9B9-541-unknown | MAAVTI... | 541 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt134193 | |||
| Q8C9B9-808-unknown | SEEQQE... | 808 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32518 | |||
| Q8C9B9-808-unknown | SEEQQE... | 808 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156518 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...PPVSDS | 807 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32518 | |||
| ...PPVSDS | 807 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140002 | |||
| ...AAAQA | 2256 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_MOUSE | 807 | VSDS.|.SEEQ | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|