Q8IUD2: ELKS/Rab6-interacting/CAST family member 1

General Information

Protein names	- ELKS/Rab6-interacting/CAST family member 1 - ERC-1 - Rab6-interacting protein 2
Gene names	ERC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IUD2

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ELKS/Rab6-interacting/CAST family member 1 - Isoform 3 of ELKS/Rab6-interacting/CAST family member 1 - Isoform 4 of ELKS/Rab6-interacting/CAST family member 1 - Isoform 5 of ELKS/Rab6-interacting/CAST family member 1

Sequence View

        10         20         30         40         50         60
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ
        70         80         90        100        110        120
SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS
       130        140        150        160        170        180
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS
       190        200        210        220        230        240
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR
       250        260        270        280        290        300
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
       310        320        330        340        350        360
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML
       370        380        390        400        410        420
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE
       430        440        450        460        470        480
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT
       490        500        510        520        530        540
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK
       550        560        570        580        590        600
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
       610        620        630        640        650        660
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK
       670        680        690        700        710        720
VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA
       730        740        750        760        770        780
HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA
       790        800        810        820        830        840
ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE
       850        860        870        880        890        900
ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
       910        920        930        940        950        960
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA
       970        980        990       1000       1010       1020
LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR
      1030       1040       1050       1060       1070       1080
SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE
      1090       1100       1110
RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS         10         20         30         40         50         60
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ
        70         80         90        100        110        120
SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS
       130        140        150        160        170        180
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS
       190        200        210        220        230        240
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR
       250        260        270        280        290        300
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
       310        320        330        340        350        360
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML
       370        380        390        400        410        420
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE
       430        440        450        460        470        480
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT
       490        500        510        520        530        540
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK
       550        560        570        580        590        600
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
       610        620        630        640        650        660
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK
       670        680        690        700        710        720
VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA
       730        740        750        760        770        780
HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA
       790        800        810        820        830        840
ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE
       850        860        870        880        890        900
ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
       910        920        930        940        950        960
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA
       970        980        990       1000       1010       1020
LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR
      1030       1040       1050       1060       1070       1080
SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE
      1090       1100       1110
RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS         10         20         30         40         50         60
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ
        70         80         90        100        110        120
SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS
       130        140        150        160        170        180
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS
       190        200        210        220        230        240
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR
       250        260        270        280        290        300
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
       310        320        330        340        350        360
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML
       370        380        390        400        410        420
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE
       430        440        450        460        470        480
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT
       490        500        510        520        530        540
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK
       550        560        570        580        590        600
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
       610        620        630        640        650        660
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK
       670        680        690        700        710        720
VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA
       730        740        750        760        770        780
HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA
       790        800        810        820        830        840
ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE
       850        860        870        880        890        900
ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
       910        920        930        940        950        960
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA
       970        980        990       1000       1010       1020
LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR
      1030       1040       1050       1060       1070       1080
SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE
      1090       1100       1110
RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS         10         20         30         40         50         60
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ
        70         80         90        100        110        120
SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS
       130        140        150        160        170        180
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS
       190        200        210        220        230        240
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR
       250        260        270        280        290        300
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ
       310        320        330        340        350        360
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML
       370        380        390        400        410        420
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE
       430        440        450        460        470        480
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT
       490        500        510        520        530        540
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK
       550        560        570        580        590        600
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER
       610        620        630        640        650        660
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK
       670        680        690        700        710        720
VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA
       730        740        750        760        770        780
HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA
       790        800        810        820        830        840
ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE
       850        860        870        880        890        900
ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ
       910        920        930        940        950        960
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA
       970        980        990       1000       1010       1020
LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR
      1030       1040       1050       1060       1070       1080
SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE
      1090       1100       1110
RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IUD2-1-unknown	MYGSAR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IUD2-1-unknown	MYGSAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87030
Q8IUD2-1-unknown	MYGSAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87031
Q8IUD2-1-unknown	MYGSAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87032
Q8IUD2-1-unknown	MYGSAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt87033
Q8IUD2-122-unknown	TIAFGE...	122	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12780
Q8IUD2-122-unknown	TIAFGE...	122	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143578
Q8IUD2-122-unknown	TIAFGE...	122	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143579
Q8IUD2-122-unknown	TIAFGE...	122	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143580
Q8IUD2-122-unknown	TIAFGE...	122	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143581
Q8IUD2-613-unknown	TALTTL...	613	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175872
Q8IUD2-613-unknown	TALTTL...	613	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175873
Q8IUD2-613-unknown	TALTTL...	613	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175874
Q8IUD2-613-unknown	TALTTL...	613	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175875
Q8IUD2-613-	TALTTL...	613		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVASDT	121	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12780
...GVASDT	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126820
...GVASDT	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126821
...GVASDT	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126822
...GVASDT	121	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126823
...LEESS	1116	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LEESS	1116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82649

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	121	ASDT.\|.TIAF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)