Q8IVT5: Kinase suppressor of Ras 1

General Information

Protein names	- Kinase suppressor of Ras 1
Gene names	KSR1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IVT5

10 N-termini

5 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Kinase suppressor of Ras 1 - Isoform 3 of Kinase suppressor of Ras 1 - Isoform 2 of Kinase suppressor of Ras 1 - Isoform 3 of Kinase suppressor of Ras 1 - Isoform 4 of Kinase suppressor of Ras 1

Sequence View

        10         20         30         40         50         60
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
        70         80         90        100        110        120
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
       130        140        150        160        170        180
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
       190        200        210        220        230        240
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
       250        260        270        280        290        300
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
       310        320        330        340        350        360
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
       370        380        390        400        410        420
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
       430        440        450        460        470        480
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
       490        500        510        520        530        540
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
       550        560        570        580        590        600
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
       610        620        630        640        650        660
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
       670        680        690        700        710        720
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
       730        740        750        760        770        780
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
       790        800        810        820        830        840
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
       850        860        870        880        890        900
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
       910        920
SSKVVPRFER FGLGVLESSN PKM         10         20         30         40         50         60
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
        70         80         90        100        110        120
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
       130        140        150        160        170        180
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
       190        200        210        220        230        240
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
       250        260        270        280        290        300
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
       310        320        330        340        350        360
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
       370        380        390        400        410        420
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
       430        440        450        460        470        480
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
       490        500        510        520        530        540
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
       550        560        570        580        590        600
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
       610        620        630        640        650        660
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
       670        680        690        700        710        720
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
       730        740        750        760        770        780
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
       790        800        810        820        830        840
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
       850        860        870        880        890        900
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
       910        920
SSKVVPRFER FGLGVLESSN PKM         10         20         30         40         50         60
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
        70         80         90        100        110        120
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
       130        140        150        160        170        180
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
       190        200        210        220        230        240
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
       250        260        270        280        290        300
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
       310        320        330        340        350        360
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
       370        380        390        400        410        420
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
       430        440        450        460        470        480
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
       490        500        510        520        530        540
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
       550        560        570        580        590        600
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
       610        620        630        640        650        660
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
       670        680        690        700        710        720
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
       730        740        750        760        770        780
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
       790        800        810        820        830        840
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
       850        860        870        880        890        900
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
       910        920
SSKVVPRFER FGLGVLESSN PKM         10         20         30         40         50         60
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
        70         80         90        100        110        120
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
       130        140        150        160        170        180
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
       190        200        210        220        230        240
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
       250        260        270        280        290        300
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
       310        320        330        340        350        360
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
       370        380        390        400        410        420
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
       430        440        450        460        470        480
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
       490        500        510        520        530        540
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
       550        560        570        580        590        600
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
       610        620        630        640        650        660
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
       670        680        690        700        710        720
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
       730        740        750        760        770        780
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
       790        800        810        820        830        840
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
       850        860        870        880        890        900
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
       910        920
SSKVVPRFER FGLGVLESSN PKM         10         20         30         40         50         60
MDRAALRAAA MGEKKEGGGG GDAAAAEGGA GAAASRALQQ CGQLQKLIDI SIGSLRGLRT
        70         80         90        100        110        120
KCAVSNDLTQ QEIRTLEAKL VRYICKQRQC KLSVAPGERT PELNSYPRFS DWLYTFNVRP
       130        140        150        160        170        180
EVVQEIPRDL TLDALLEMNE AKVKETLRRC GASGDECGRL QYALTCLRKV TGLGGEHKED
       190        200        210        220        230        240
SSWSSLDARR ESGSGPSTDT LSAASLPWPP GSSQLGRAGN SAQGPRSISV SALPASDSPT
       250        260        270        280        290        300
PSFSEGLSDT CIPLHASGRL TPRALHSFIT PPTTPQLRRH TKLKPPRTPP PPSRKVFQLL
       310        320        330        340        350        360
PSFPTLTRSK SHESQLGNRI DDVSSMRFDL SHGSPQMVRR DIGLSVTHRF STKSWLSQVC
       370        380        390        400        410        420
HVCQKSMIFG VKCKHCRLKC HNKCTKEAPA CRISFLPLTR LRRTESVPSD INNPVDRAAE
       430        440        450        460        470        480
PHFGTLPKAL TKKEHPPAMN HLDSSSNPSS TTSSTPSSPA PFPTSSNPSS ATTPPNPSPG
       490        500        510        520        530        540
QRDSRFNFPA AYFIHHRQQF IFPVPSAGHC WKCLLIAESL KENAFNISAF AHAAPLPEAA
       550        560        570        580        590        600
DGTRLDDQPK ADVLEAHEAE AEEPEAGKSE AEDDEDEVDD LPSSRRPWRG PISRKASQTS
       610        620        630        640        650        660
VYLQEWDIPF EQVELGEPIG QGRWGRVHRG RWHGEVAIRL LEMDGHNQDH LKLFKKEVMN
       670        680        690        700        710        720
YRQTRHENVV LFMGACMNPP HLAIITSFCK GRTLHSFVRD PKTSLDINKT RQIAQEIIKG
       730        740        750        760        770        780
MGYLHAKGIV HKDLKSKNVF YDNGKVVITD FGLFGISGVV REGRRENQLK LSHDWLCYLA
       790        800        810        820        830        840
PEIVREMTPG KDEDQLPFSK AADVYAFGTV WYELQARDWP LKNQAAEASI WQIGSGEGMK
       850        860        870        880        890        900
RVLTSVSLGK EVSEILSACW AFDLQERPSF SLLMDMLEKL PKLNRRLSHP GHFWKSADIN
       910        920
SSKVVPRFER FGLGVLESSN PKM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IVT5-1-unknown	MDRAAL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IVT5-1-unknown	MDRAAL...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79269
Q8IVT5-136-unknown	LEMNEA...	136	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79270
Q8IVT5-136-unknown	LEMNEA...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463204
Q8IVT5-136-unknown	LEMNEA...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464081
Q8IVT5-136-unknown	LEMNEA...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000381958
Q8IVT5-136-unknown	LEMNEA...	136	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000268763
Q8IVT5-136-unknown	LEMNEA...	136	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt105118
Q8IVT5-140-unknown	EAKVKE...	140	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10417
Q8IVT5-140-unknown	EAKVKE...	140	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144315
Q8IVT5-140-unknown	EAKVKE...	140	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197541
Q8IVT5-264-unknown	ALHSFI...	264	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000381952
Q8IVT5-264-unknown	ALHSFI...	264	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131659
Q8IVT5-264-unknown	ALHSFI...	264	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131658
Q8IVT5-531-	AHAAPL...	531		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q8IVT5-531-unknown	AHAAPL...	531	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178284
Q8IVT5-531-unknown	AHAAPL...	531	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178285
Q8IVT5-783-unknown	IVREMT...	783	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463790
Q8IVT5-783-unknown	IVREMT...	783	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131665
Q8IVT5-783-unknown	IVREMT...	783	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131664
Q8IVT5-785-unknown	REMTPG...	785	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464680
Q8IVT5-785-unknown	REMTPG...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131662
Q8IVT5-785-unknown	REMTPG...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131661
Q8IVT5-785-unknown	REMTPG...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131665
Q8IVT5-785-unknown	REMTPG...	785	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt131664
Q8IVT5-867-unknown	RPSFSL...	867	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176304
Q8IVT5-867-unknown	RPSFSL...	867	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176305
Q8IVT5-867-	RPSFSL...	867		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LLEMNE	139	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10417
...LLEMNE	139	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt127577
...HKEDSS	181	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000463204
...HKEDSS	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt112238
...HKEDSS	181	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt112237
...PRTPPP	290	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000464081
...PRTPPP	290	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt112241
...ESSNPK	921	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...ESSNPK	921	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt74888
...ESSNPK	921		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESSNPK	921		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...ESSNPK	921		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESSNPK	921		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	139	EMNE.\|.EAKV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)