Q8IWC1: MAP7 domain-containing protein 3

General Information

Protein names	- MAP7 domain-containing protein 3
Gene names	MAP7D3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IWC1

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of MAP7 domain-containing protein 3 - Isoform 3 of MAP7 domain-containing protein 3 - Isoform 4 of MAP7 domain-containing protein 3

Sequence View

        10         20         30         40         50         60
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG
        70         80         90        100        110        120
SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE
       130        140        150        160        170        180
EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN
       190        200        210        220        230        240
KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA
       250        260        270        280        290        300
ERKPRVTGVT NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK
       310        320        330        340        350        360
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS TYDSEMSMDA
       370        380        390        400        410        420
SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA LPEVSVEAAP EGSLEAPPKG
       430        440        450        460        470        480
SAEVAPKESV KGSPKESMEA SPEAMVKASP KTSLEASMEA SPKAKARDAP KKSEMDKQAL
       490        500        510        520        530        540
IPIAKKRLSS YTECYKWSSS PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY
       550        560        570        580        590        600
KIMPIQHTLS VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT
       610        620        630        640        650        660
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL KLKDGQQQNE
       670        680        690        700        710        720
TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI MLQNLQERLE RKKRIEEIMK
       730        740        750        760        770        780
RTRKTDVNAS KVTETSSHDI YEEAEADNEE SDKDSLNEMF PSAILNGTGS PTKFKMPFNN
       790        800        810        820        830        840
AKKMTHKLVF LEDGTSQVRK EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT
       850        860        870
KTRKADETNT TSRSSAQTKS EGFHDILPKS SDTFRQ         10         20         30         40         50         60
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG
        70         80         90        100        110        120
SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE
       130        140        150        160        170        180
EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN
       190        200        210        220        230        240
KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA
       250        260        270        280        290        300
ERKPRVTGVT NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK
       310        320        330        340        350        360
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS TYDSEMSMDA
       370        380        390        400        410        420
SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA LPEVSVEAAP EGSLEAPPKG
       430        440        450        460        470        480
SAEVAPKESV KGSPKESMEA SPEAMVKASP KTSLEASMEA SPKAKARDAP KKSEMDKQAL
       490        500        510        520        530        540
IPIAKKRLSS YTECYKWSSS PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY
       550        560        570        580        590        600
KIMPIQHTLS VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT
       610        620        630        640        650        660
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL KLKDGQQQNE
       670        680        690        700        710        720
TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI MLQNLQERLE RKKRIEEIMK
       730        740        750        760        770        780
RTRKTDVNAS KVTETSSHDI YEEAEADNEE SDKDSLNEMF PSAILNGTGS PTKFKMPFNN
       790        800        810        820        830        840
AKKMTHKLVF LEDGTSQVRK EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT
       850        860        870
KTRKADETNT TSRSSAQTKS EGFHDILPKS SDTFRQ         10         20         30         40         50         60
MMADGAAAGA GGSPSLRELR ARMVAAANEI AKERRKQDVV NRVATHSSNI RSTFKPVIDG
        70         80         90        100        110        120
SMLKNDIKQR LARERREEKR RQQDANKETQ LLEKERKTKL QYEKQMEERQ RKLKERKEKE
       130        140        150        160        170        180
EQRRIAAEEK RHQKDEAQKE KFTAILYRTL ERRRLADDYQ QKRWSWGGSA MANSESKTAN
       190        200        210        220        230        240
KRSASTEKLE QGTSALIRQM PLSSAGLQNS VAKRKTDKER SSSLNRRDSN LHSSTDKEQA
       250        260        270        280        290        300
ERKPRVTGVT NYVMQYVTVP LRKCTSDELR AVMFPMSTMK IPPQTKVEES PLEKVETPPK
       310        320        330        340        350        360
ASVDAPPQVN VEVFCNTSME ASPKAGVGMA PEVSTDSFPV VSVDVSPVVS TYDSEMSMDA
       370        380        390        400        410        420
SPELSIEALP KVDLETVPKV SIVASPEASL EAPPEVSLEA LPEVSVEAAP EGSLEAPPKG
       430        440        450        460        470        480
SAEVAPKESV KGSPKESMEA SPEAMVKASP KTSLEASMEA SPKAKARDAP KKSEMDKQAL
       490        500        510        520        530        540
IPIAKKRLSS YTECYKWSSS PENACGLPSP ISTNRQIQKN CPPSPLPLIS KQSPQTSFPY
       550        560        570        580        590        600
KIMPIQHTLS VQSASSTVKK KKETVSKTTN RCEALSQRHM IYEESGNKST AGIMNAEAAT
       610        620        630        640        650        660
KILTELRRLA REQREKEEEE RQREEMQQRV IKKSKDMAKE AVGGQAEDHL KLKDGQQQNE
       670        680        690        700        710        720
TKKKKGWLDQ EDQEAPLQKG DAKIKAQEEA DKRKKEHERI MLQNLQERLE RKKRIEEIMK
       730        740        750        760        770        780
RTRKTDVNAS KVTETSSHDI YEEAEADNEE SDKDSLNEMF PSAILNGTGS PTKFKMPFNN
       790        800        810        820        830        840
AKKMTHKLVF LEDGTSQVRK EPKTYFNGDL KNFRQKSMKD TSIQEVVSRP SSKRMTSHTT
       850        860        870
KTRKADETNT TSRSSAQTKS EGFHDILPKS SDTFRQ

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IWC1-1-unknown	MMADGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80229
Q8IWC1-1-unknown	MMADGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80230
Q8IWC1-1-Acetylation	MMADGA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IWC1-1-Acetylation	MMADGA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96768
Q8IWC1-1-Acetylation	MMADGA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96769
Q8IWC1-101-unknown	QYEKQM...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14700
Q8IWC1-101-unknown	QYEKQM...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141475
Q8IWC1-101-unknown	QYEKQM...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142450
Q8IWC1-101-unknown	QYEKQM...	101		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142452
Q8IWC1-360-unknown	ASPELS...	360		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175859
Q8IWC1-360-unknown	ASPELS...	360		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175858
Q8IWC1-360-unknown	ASPELS...	360		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175857
Q8IWC1-360-	ASPELS...	360			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RKTKLQ	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14700
...RKTKLQ	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124649
...RKTKLQ	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125644
...RKTKLQ	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125646
...DTFRQ	876	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DTFRQ	876	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75847
...DTFRQ	876	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75848
...DTFRQ	876	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75849

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	100	TKLQ.\|.QYEK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)