Q8IWJ2: GRIP and coiled-coil domain-containing protein 2

General Information

Protein names	- GRIP and coiled-coil domain-containing protein 2 - 185 kDa Golgi coiled-coil protein - GCC185 - CLL-associated antigen KW-11 - CTCL tumor antigen se1-1 - Ran-binding protein 2-like 4 - RanBP2L4 - Renal carcinoma antigen NY-REN-53
Gene names	GCC2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q8IWJ2

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MEDLVQDGVA SPATPGTGKS KLETLPKEDL IKFAKKQMML IQKAKSRCTE LEKEIEELRS
        70         80         90        100        110        120
KPVTEGTGDI IKALTERLDA LLLEKAETEQ QCLSLKKENI KMKQEVEDSV TKMGDAHKEL
       130        140        150        160        170        180
EQSHINYVKE IENLKNELMA VRSKYSEDKA NLQKQLEEAM NTQLELSEQL KFQNNSEDNV
       190        200        210        220        230        240
KKLQEEIEKI RPGFEEQILY LQKQLDATTD EKKETVTQLQ NIIEANSQHY QKNINSLQEE
       250        260        270        280        290        300
LLQLKAIHQE EVKELMCQIE ASAKEHEAEI NKLNELKENL VKQCEASEKN IQKKYECELE
       310        320        330        340        350        360
NLRKATSNAN QDNQICSILL QENTFVEQVV NEKVKHLEDT LKELESQHSI LKDEVTYMNN
       370        380        390        400        410        420
LKLKLEMDAQ HIKDEFFHER EDLEFKINEL LLAKEEQGCV IEKLKSELAG LNKQFCYTVE
       430        440        450        460        470        480
QHNREVQSLK EQHQKEISEL NETFLSDSEK EKLTLMFEIQ GLKEQCENLQ QEKQEAILNY
       490        500        510        520        530        540
ESLREIMEIL QTELGESAGK ISQEFESMKQ QQASDVHELQ QKLRTAFTEK DALLETVNRL
       550        560        570        580        590        600
QGENEKLLSQ QELVPELENT IKNLQEKNGV YLLSLSQRDT MLKELEGKIN SLTEEKDDFI
       610        620        630        640        650        660
NKLKNSHEEM DNFHKKCERE ERLILELGKK VEQTIQYNSE LEQKVNELTG GLEETLKEKD
       670        680        690        700        710        720
QNDQKLEKLM VQMKVLSEDK EVLSAEVKSL YEENNKLSSE KKQLSRDLEV FLSQKEDVIL
       730        740        750        760        770        780
KEHITQLEKK LQLMVEEQDN LNKLLENEQV QKLFVKTQLY GFLKEMGSEV SEDSEEKDVV
       790        800        810        820        830        840
NVLQAVGESL AKINEEKCNL AFQRDEKVLE LEKEIKCLQE ESVVQCEELK SLLRDYEQEK
       850        860        870        880        890        900
VLLRKELEEI QSEKEALQSD LLEMKNANEK TRLENQNLLI QVEEVSQTCS KSEIHNEKEK
       910        920        930        940        950        960
CFIKEHENLK PLLEQKELRD RRAELILLKD SLAKSPSVKN DPLSSVKELE EKIENLEKEC
       970        980        990       1000       1010       1020
KEKEEKINKI KLVAVKAKKE LDSSRKETQT VKEELESLRS EKDQLSASMR DLIQGAESYK
      1030       1040       1050       1060       1070       1080
NLLLEYEKQS EQLDVEKERA NNFEHRIEDL TRQLRNSTLQ CETINSDNED LLARIETLQS
      1090       1100       1110       1120       1130       1140
NAKLLEVQIL EVQRAKAMVD KELEAEKLQK EQKIKEHATT VNELEELQVQ LQKQKKQLQK
      1150       1160       1170       1180       1190       1200
TMQELELVKK DAQQTTLMNM EIADYERLMK ELNQKLTNKN NKIEDLEQEI KIQKQKQETL
      1210       1220       1230       1240       1250       1260
QEEITSLQSS VQQYEEKNTK IKQLLVKTKK ELADSKQAET DHLILQASLK GELEASQQQV
      1270       1280       1290       1300       1310       1320
EVYKIQLAEI TSEKHKIHEH LKTSAEQHQR TLSAYQQRVT ALQEECRAAK AEQATVTSEF
      1330       1340       1350       1360       1370       1380
ESYKVRVHNV LKQQKNKSMS QAETEGAKQE REHLEMLIDQ LKIKLQDSQN NLQINVSELQ
      1390       1400       1410       1420       1430       1440
TLQSEHDTLL ERHNKMLQET VSKEAELREK LCSIQSENMM MKSEHTQTVS QLTSQNEVLR
      1450       1460       1470       1480       1490       1500
NSFRDQVRHL QEEHRKTVET LQQQLSKMEA QLFQLKNEPT TRSPVSSQQS LKNLRERRNT
      1510       1520       1530       1540       1550       1560
DLPLLDMHTV TREEGEGMET TDTESVSSAS TYTQSLEQLL NSPETKLEPP LWHAEFTKEE
      1570       1580       1590       1600       1610       1620
LVQKLSSTTK SADHLNGLLR ETEATNAILM EQIKLLKSEI RRLERNQERE KSAANLEYLK
      1630       1640       1650       1660       1670       1680
NVLLQFIFLK PGSERERLLP VINTMLQLSP EEKGKLAAVA QGEEENASRS SGWASYLHSW

SGLR

Isoforms

- Isoform 2 of GRIP and coiled-coil domain-containing protein 2

Sequence View

        10         20         30         40         50         60
MEDLVQDGVA SPATPGTGKS KLETLPKEDL IKFAKKQMML IQKAKSRCTE LEKEIEELRS
        70         80         90        100        110        120
KPVTEGTGDI IKALTERLDA LLLEKAETEQ QCLSLKKENI KMKQEVEDSV TKMGDAHKEL
       130        140        150        160        170        180
EQSHINYVKE IENLKNELMA VRSKYSEDKA NLQKQLEEAM NTQLELSEQL KFQNNSEDNV
       190        200        210        220        230        240
KKLQEEIEKI RPGFEEQILY LQKQLDATTD EKKETVTQLQ NIIEANSQHY QKNINSLQEE
       250        260        270        280        290        300
LLQLKAIHQE EVKELMCQIE ASAKEHEAEI NKLNELKENL VKQCEASEKN IQKKYECELE
       310        320        330        340        350        360
NLRKATSNAN QDNQICSILL QENTFVEQVV NEKVKHLEDT LKELESQHSI LKDEVTYMNN
       370        380        390        400        410        420
LKLKLEMDAQ HIKDEFFHER EDLEFKINEL LLAKEEQGCV IEKLKSELAG LNKQFCYTVE
       430        440        450        460        470        480
QHNREVQSLK EQHQKEISEL NETFLSDSEK EKLTLMFEIQ GLKEQCENLQ QEKQEAILNY
       490        500        510        520        530        540
ESLREIMEIL QTELGESAGK ISQEFESMKQ QQASDVHELQ QKLRTAFTEK DALLETVNRL
       550        560        570        580        590        600
QGENEKLLSQ QELVPELENT IKNLQEKNGV YLLSLSQRDT MLKELEGKIN SLTEEKDDFI
       610        620        630        640        650        660
NKLKNSHEEM DNFHKKCERE ERLILELGKK VEQTIQYNSE LEQKVNELTG GLEETLKEKD
       670        680        690        700        710        720
QNDQKLEKLM VQMKVLSEDK EVLSAEVKSL YEENNKLSSE KKQLSRDLEV FLSQKEDVIL
       730        740        750        760        770        780
KEHITQLEKK LQLMVEEQDN LNKLLENEQV QKLFVKTQLY GFLKEMGSEV SEDSEEKDVV
       790        800        810        820        830        840
NVLQAVGESL AKINEEKCNL AFQRDEKVLE LEKEIKCLQE ESVVQCEELK SLLRDYEQEK
       850        860        870        880        890        900
VLLRKELEEI QSEKEALQSD LLEMKNANEK TRLENQNLLI QVEEVSQTCS KSEIHNEKEK
       910        920        930        940        950        960
CFIKEHENLK PLLEQKELRD RRAELILLKD SLAKSPSVKN DPLSSVKELE EKIENLEKEC
       970        980        990       1000       1010       1020
KEKEEKINKI KLVAVKAKKE LDSSRKETQT VKEELESLRS EKDQLSASMR DLIQGAESYK
      1030       1040       1050       1060       1070       1080
NLLLEYEKQS EQLDVEKERA NNFEHRIEDL TRQLRNSTLQ CETINSDNED LLARIETLQS
      1090       1100       1110       1120       1130       1140
NAKLLEVQIL EVQRAKAMVD KELEAEKLQK EQKIKEHATT VNELEELQVQ LQKQKKQLQK
      1150       1160       1170       1180       1190       1200
TMQELELVKK DAQQTTLMNM EIADYERLMK ELNQKLTNKN NKIEDLEQEI KIQKQKQETL
      1210       1220       1230       1240       1250       1260
QEEITSLQSS VQQYEEKNTK IKQLLVKTKK ELADSKQAET DHLILQASLK GELEASQQQV
      1270       1280       1290       1300       1310       1320
EVYKIQLAEI TSEKHKIHEH LKTSAEQHQR TLSAYQQRVT ALQEECRAAK AEQATVTSEF
      1330       1340       1350       1360       1370       1380
ESYKVRVHNV LKQQKNKSMS QAETEGAKQE REHLEMLIDQ LKIKLQDSQN NLQINVSELQ
      1390       1400       1410       1420       1430       1440
TLQSEHDTLL ERHNKMLQET VSKEAELREK LCSIQSENMM MKSEHTQTVS QLTSQNEVLR
      1450       1460       1470       1480       1490       1500
NSFRDQVRHL QEEHRKTVET LQQQLSKMEA QLFQLKNEPT TRSPVSSQQS LKNLRERRNT
      1510       1520       1530       1540       1550       1560
DLPLLDMHTV TREEGEGMET TDTESVSSAS TYTQSLEQLL NSPETKLEPP LWHAEFTKEE
      1570       1580       1590       1600       1610       1620
LVQKLSSTTK SADHLNGLLR ETEATNAILM EQIKLLKSEI RRLERNQERE KSAANLEYLK
      1630       1640       1650       1660       1670       1680
NVLLQFIFLK PGSERERLLP VINTMLQLSP EEKGKLAAVA QGEEENASRS SGWASYLHSW

SGLR

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q8IWJ2-1-unknown	MEDLVQ...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75783
Q8IWJ2-1-Acetylation	MEDLVQ...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q8IWJ2-1-Acetylation	MEDLVQ...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt108515
Q8IWJ2-8-	GVASPA...	8			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q8IWJ2-8-	GVASPA...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q8IWJ2-8-	GVASPA...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q8IWJ2-8-	GVASPA...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

TopFIND

Q8IWJ2: GRIP and coiled-coil domain-containing protein 2

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates