Q8IWN7: Retinitis pigmentosa 1-like 1 protein
| Protein names | - Retinitis pigmentosa 1-like 1 protein |
|---|---|
| Gene names | RP1L1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q8IWN7 |
2
N-termini
2
C-termini
1
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MNSTPRNAQA PSHRECFLPS VARTPSVTKV TPAKKITFLK RGDPRFAGVR LAVHQRAFKT
70 80 90 100 110 120
FSALMDELSQ RVPLSFGVRS VTTPRGLHSL SALEQLEDGG CYLCSDKKPP KTPSGPGRPQ
130 140 150 160 170 180
ERNPTAQQLR DVEGQREAPG TSSSRKSLKT PRRILLIKNM DPRLQQTVVL SHRNTRNLAA
190 200 210 220 230 240
FLGKASDLLR FPVKQLYTTS GKKVDSLQAL LHSPSVLVCA GHEAFRTPAM KNARRSEAET
250 260 270 280 290 300
LSGLTSRNKN GSWGPKTKPS VIHSRSPPGS TPRLPERPGP SNPPVGPAPG RHPQDTPAQS
310 320 330 340 350 360
GPLVAGDDMK KKVRMNEDGS LSVEMKVRFH LVGEDTLLWS RRMGRASALT AASGEDPVLG
370 380 390 400 410 420
EVDPLCCVWE GYPWGFSEPG VWGPRPCRVG CREVFGRGGQ PGPKYEIWTN PLHASQGERV
430 440 450 460 470 480
AARKRWGLAQ HVRCSGLWGH GTAGRERCSQ DSASPASSTG LPEGSEPESS CCPRTPEDGV
490 500 510 520 530 540
DSASPSAQIG AERKAGGSLG EDPGLCIDGA GLGGPEQGGR LTPRARSEEG ASSDSSASTG
550 560 570 580 590 600
SHEGSSEWGG RPQGCPGKAR AETSQQEASE GGDPASPALS LSSLRSDDLQ AETQGQGTEQ
610 620 630 640 650 660
ATGAAVTREP LVLGLSCSWD SEGASSTPST CTSSQQGQRR HRSRASAMSS PSSPGLGRVA
670 680 690 700 710 720
PRGHPRHSHY RKDTHSPLDS SVTKQVPRPP ERRRACQDGS VPRYSGSSSS TRTQASGNLR
730 740 750 760 770 780
PPSSGSLPSQ DLLGTSSATV TPAVHSDFVS GVSPHNAPSA GWAGDAGSRT CSPAPIPPHT
790 800 810 820 830 840
SDSCSKSGAA SLGEEARDTP QPSSPLVLQV GRPEQGAVGP HRSHCCSQPG TQPAQEAQRG
850 860 870 880 890 900
PSPEASWLCG RYCPTPPRGR PCPQRRSSSC GSTGSSHQST ARGPGGSPQE GTRQPGPTPS
910 920 930 940 950 960
PGPNSGASRR SSASQGAGSR GLSEEKTLRS GGGPQGQEEA SGVSPSSLPR SSPEAVVREW
970 980 990 1000 1010 1020
LDNIPEEPIL MTYELADETT GAAGGGLRGP EVDPGDDHSL EGLGEPAQAG QQSLEGDPGQ
1030 1040 1050 1060 1070 1080
DPEPEGALLG SSDTGPQSGE GVPQGAAPEG VSEAPAEAGA DREAPAGCRV SLRALPGRVS
1090 1100 1110 1120 1130 1140
ASTQIMRALM GSKQGRPSSV PEVSRPMARR LSCSAGALIT CLASLQLFEE DLGSPASKVR
1150 1160 1170 1180 1190 1200
FKDSPRYQEL LSISKDLWPG CDVGEDQLDS GLWELTWSQA LPDLGSHAMT ENFTPTSSSG
1210 1220 1230 1240 1250 1260
VDISSGSGGS GESSVPCAMD GTLVTQGTEL PLKTSNQRPD SRTYESPGDL ENQQQCCFPT
1270 1280 1290 1300 1310 1320
FLNARACACA TNEDEAERDS EEQRASSNLE QLAENTVQEE VQLEETKEGT EGEGLQEEAV
1330 1340 1350 1360 1370 1380
QLEETKTEEG LQEEGVQLEE TKETEGEGQQ EEEAQLEEIE ETGGEGLQEE GVQLEEVKEG
1390 1400 1410 1420 1430 1440
PEGGLQGEAL EEGLKEEGLP EEGSVHGQEL SEASSPDGKG SQEDDPVQEE EAGRASASAE
1450 1460 1470 1480 1490 1500
PCPAEGTEEP TEPPSHLSET DPSASERQSG SQLEPGLEKP PGATMMGQEH TQAQPTQGAA
1510 1520 1530 1540 1550 1560
ERSSSVACSA ALDCDPIWVS VLLKKTEKAF LAHLASAVAE LRARWGLQDN DLLDQMAAEL
1570 1580 1590 1600 1610 1620
QQDVAQRLQD STKRELQKLQ GRAGRMVLEP PREALTGELL LQTQQRRHRL RGLRNLSAFS
1630 1640 1650 1660 1670 1680
ERTLGLGPLS FTLEDEPALS TALGSQLGEE AEGEEFCPCE ACVRKKVSPM SPKATMGATR
1690 1700 1710 1720 1730 1740
GPIKEAFDLQ QILQRKRGEH TDGEAAEVAP GKTHTDPTST RTVQGAEGGL GPGLSQGPGV
1750 1760 1770 1780 1790 1800
DEGEDGEGSQ RLNRDKDPKL GEAEGDAMAQ EREGKTHNSE TSAGSELGEA EQEGEGISER
1810 1820 1830 1840 1850 1860
GETGGQGSGH EDNLQGEAAA GGDQDPGQSD GAEGIEAPEA EGEAQPESEG VEAPEAEGDA
1870 1880 1890 1900 1910 1920
QEAEGEAQPE SEDVEAPEAE GEAQPESEDV ETPEAEWEVQ PESEGAEAPE AEKEAQPETE
1930 1940 1950 1960 1970 1980
SVEALETEGE DEPESEGAEA QEAEEAAQEA EGQTQPESEV IESQEAEEEA QPESEDVEAL
1990 2000 2010 2020 2030 2040
EVEVETQEAE GEAQPESEDV EAPEAEGEMQ EAEEEAQPES DGVEAQPKSE GEEAQEVEGE
2050 2060 2070 2080 2090 2100
TQKTEGDAQP ESDGVEAPEA EEEAQEAEGE VQEAEGEAHP ESEDVDAQEA EGEAQPESEG
2110 2120 2130 2140 2150 2160
VEAPEAEGEA QKAEGIEAPE TEGEAQPESE GIEAPEAEGE AQPESEGVEA QDAEGEAQPE
2170 2180 2190 2200 2210 2220
SEGIEAQEAE EEAQPELEGV EAPEAEGEAQ PESEGIEAPE AEGEAQPELE GVEAPEAEEE
2230 2240 2250 2260 2270 2280
AQPEPEGVET PEAEGEAQPE SEGETQGEKK GSPQVSLGDG QSEEASESSS PVPEDRPTPP
2290 2300 2310 2320 2330 2340
PSPGGDTPHQ RPGSQTGPSS SRASSWGNCW QKDSENDHVL GDTRSPDAKS TGTPHAERKA
2350 2360 2370 2380 2390 2400
TRMYPESSTS EQEEAPLGSR TPEQGASEGY DLQEDQALGS LAPTEAVGRA DGFGQDDLDF
Isoforms
- Isoform 2 of Retinitis pigmentosa 1-like 1 proteinSequence View
10 20 30 40 50 60
MNSTPRNAQA PSHRECFLPS VARTPSVTKV TPAKKITFLK RGDPRFAGVR LAVHQRAFKT
70 80 90 100 110 120
FSALMDELSQ RVPLSFGVRS VTTPRGLHSL SALEQLEDGG CYLCSDKKPP KTPSGPGRPQ
130 140 150 160 170 180
ERNPTAQQLR DVEGQREAPG TSSSRKSLKT PRRILLIKNM DPRLQQTVVL SHRNTRNLAA
190 200 210 220 230 240
FLGKASDLLR FPVKQLYTTS GKKVDSLQAL LHSPSVLVCA GHEAFRTPAM KNARRSEAET
250 260 270 280 290 300
LSGLTSRNKN GSWGPKTKPS VIHSRSPPGS TPRLPERPGP SNPPVGPAPG RHPQDTPAQS
310 320 330 340 350 360
GPLVAGDDMK KKVRMNEDGS LSVEMKVRFH LVGEDTLLWS RRMGRASALT AASGEDPVLG
370 380 390 400 410 420
EVDPLCCVWE GYPWGFSEPG VWGPRPCRVG CREVFGRGGQ PGPKYEIWTN PLHASQGERV
430 440 450 460 470 480
AARKRWGLAQ HVRCSGLWGH GTAGRERCSQ DSASPASSTG LPEGSEPESS CCPRTPEDGV
490 500 510 520 530 540
DSASPSAQIG AERKAGGSLG EDPGLCIDGA GLGGPEQGGR LTPRARSEEG ASSDSSASTG
550 560 570 580 590 600
SHEGSSEWGG RPQGCPGKAR AETSQQEASE GGDPASPALS LSSLRSDDLQ AETQGQGTEQ
610 620 630 640 650 660
ATGAAVTREP LVLGLSCSWD SEGASSTPST CTSSQQGQRR HRSRASAMSS PSSPGLGRVA
670 680 690 700 710 720
PRGHPRHSHY RKDTHSPLDS SVTKQVPRPP ERRRACQDGS VPRYSGSSSS TRTQASGNLR
730 740 750 760 770 780
PPSSGSLPSQ DLLGTSSATV TPAVHSDFVS GVSPHNAPSA GWAGDAGSRT CSPAPIPPHT
790 800 810 820 830 840
SDSCSKSGAA SLGEEARDTP QPSSPLVLQV GRPEQGAVGP HRSHCCSQPG TQPAQEAQRG
850 860 870 880 890 900
PSPEASWLCG RYCPTPPRGR PCPQRRSSSC GSTGSSHQST ARGPGGSPQE GTRQPGPTPS
910 920 930 940 950 960
PGPNSGASRR SSASQGAGSR GLSEEKTLRS GGGPQGQEEA SGVSPSSLPR SSPEAVVREW
970 980 990 1000 1010 1020
LDNIPEEPIL MTYELADETT GAAGGGLRGP EVDPGDDHSL EGLGEPAQAG QQSLEGDPGQ
1030 1040 1050 1060 1070 1080
DPEPEGALLG SSDTGPQSGE GVPQGAAPEG VSEAPAEAGA DREAPAGCRV SLRALPGRVS
1090 1100 1110 1120 1130 1140
ASTQIMRALM GSKQGRPSSV PEVSRPMARR LSCSAGALIT CLASLQLFEE DLGSPASKVR
1150 1160 1170 1180 1190 1200
FKDSPRYQEL LSISKDLWPG CDVGEDQLDS GLWELTWSQA LPDLGSHAMT ENFTPTSSSG
1210 1220 1230 1240 1250 1260
VDISSGSGGS GESSVPCAMD GTLVTQGTEL PLKTSNQRPD SRTYESPGDL ENQQQCCFPT
1270 1280 1290 1300 1310 1320
FLNARACACA TNEDEAERDS EEQRASSNLE QLAENTVQEE VQLEETKEGT EGEGLQEEAV
1330 1340 1350 1360 1370 1380
QLEETKTEEG LQEEGVQLEE TKETEGEGQQ EEEAQLEEIE ETGGEGLQEE GVQLEEVKEG
1390 1400 1410 1420 1430 1440
PEGGLQGEAL EEGLKEEGLP EEGSVHGQEL SEASSPDGKG SQEDDPVQEE EAGRASASAE
1450 1460 1470 1480 1490 1500
PCPAEGTEEP TEPPSHLSET DPSASERQSG SQLEPGLEKP PGATMMGQEH TQAQPTQGAA
1510 1520 1530 1540 1550 1560
ERSSSVACSA ALDCDPIWVS VLLKKTEKAF LAHLASAVAE LRARWGLQDN DLLDQMAAEL
1570 1580 1590 1600 1610 1620
QQDVAQRLQD STKRELQKLQ GRAGRMVLEP PREALTGELL LQTQQRRHRL RGLRNLSAFS
1630 1640 1650 1660 1670 1680
ERTLGLGPLS FTLEDEPALS TALGSQLGEE AEGEEFCPCE ACVRKKVSPM SPKATMGATR
1690 1700 1710 1720 1730 1740
GPIKEAFDLQ QILQRKRGEH TDGEAAEVAP GKTHTDPTST RTVQGAEGGL GPGLSQGPGV
1750 1760 1770 1780 1790 1800
DEGEDGEGSQ RLNRDKDPKL GEAEGDAMAQ EREGKTHNSE TSAGSELGEA EQEGEGISER
1810 1820 1830 1840 1850 1860
GETGGQGSGH EDNLQGEAAA GGDQDPGQSD GAEGIEAPEA EGEAQPESEG VEAPEAEGDA
1870 1880 1890 1900 1910 1920
QEAEGEAQPE SEDVEAPEAE GEAQPESEDV ETPEAEWEVQ PESEGAEAPE AEKEAQPETE
1930 1940 1950 1960 1970 1980
SVEALETEGE DEPESEGAEA QEAEEAAQEA EGQTQPESEV IESQEAEEEA QPESEDVEAL
1990 2000 2010 2020 2030 2040
EVEVETQEAE GEAQPESEDV EAPEAEGEMQ EAEEEAQPES DGVEAQPKSE GEEAQEVEGE
2050 2060 2070 2080 2090 2100
TQKTEGDAQP ESDGVEAPEA EEEAQEAEGE VQEAEGEAHP ESEDVDAQEA EGEAQPESEG
2110 2120 2130 2140 2150 2160
VEAPEAEGEA QKAEGIEAPE TEGEAQPESE GIEAPEAEGE AQPESEGVEA QDAEGEAQPE
2170 2180 2190 2200 2210 2220
SEGIEAQEAE EEAQPELEGV EAPEAEGEAQ PESEGIEAPE AEGEAQPELE GVEAPEAEEE
2230 2240 2250 2260 2270 2280
AQPEPEGVET PEAEGEAQPE SEGETQGEKK GSPQVSLGDG QSEEASESSS PVPEDRPTPP
2290 2300 2310 2320 2330 2340
PSPGGDTPHQ RPGSQTGPSS SRASSWGNCW QKDSENDHVL GDTRSPDAKS TGTPHAERKA
2350 2360 2370 2380 2390 2400
TRMYPESSTS EQEEAPLGSR TPEQGASEGY DLQEDQALGS LAPTEAVGRA DGFGQDDLDF
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q8IWN7-1-unknown | MNSTPR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q8IWN7-1-unknown | MNSTPR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt88099 | |||
| Q8IWN7-566-unknown | QEASEG... | 566 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4154 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...AETSQQ | 565 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC4154 | |||
| ... | 2480 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CATB_HUMAN | 565 | TSQQ.|.QEAS | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|