Q8K284: General transcription factor 3C polypeptide 1
| Protein names | - General transcription factor 3C polypeptide 1 - TF3C-alpha - TFIIIC box B-binding subunit - Transcription factor IIIC 220 kDa subunit - TFIIIC 220 kDa subunit - TFIIIC220 - Transcription factor IIIC subunit alpha |
|---|---|
| Gene names | Gtf3c1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q8K284 |
4
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA LATHPGISFY
70 80 90 100 110 120
EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI HMILENKDGI QGSCRYFKER
130 140 150 160 170 180
KDITSSIRSK CLQPRCTMVE AFSRWGKKLI IVASQDMRYR ALIGLEGDPD LKLPDFSYCI
190 200 210 220 230 240
LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI
250 260 270 280 290 300
LLLLNRFHVD RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA
310 320 330 340 350 360
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD DDEEVISKGV
370 380 390 400 410 420
PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK LEARMLCRLL QRFKVVKGFM
430 440 450 460 470 480
EDEGRQRTTK YISCVFAEES DLSRQYAREK ARGELLTTVS LASVQDESLM PEGEEAFLSD
490 500 510 520 530 540
SESEEESSCS GGKRRGRGSR GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA
550 560 570 580 590 600
EERSRRSSAC RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR
610 620 630 640 650 660
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSII
670 680 690 700 710 720
RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA
730 740 750 760 770 780
NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN SDPNTSSKPE STRVKKTDEK MGITPLKNYK
790 800 810 820 830 840
PVIVPGLGRS IGFLPKMPRL KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG
850 860 870 880 890 900
AQPSSGDDWD TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL
910 920 930 940 950 960
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ LLYKRRYIFS
970 980 990 1000 1010 1020
VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD TTICDPHYNL AHSSRPFERR
1030 1040 1050 1060 1070 1080
LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR CPCAQKICPD PGSDPEGSLR KEQESAMDKH
1090 1100 1110 1120 1130 1140
NLERKCAMLE YTTGSREVVD EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN
1150 1160 1170 1180 1190 1200
TSENGLTGRL QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN
1210 1220 1230 1240 1250 1260
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR MMTRLRVSWS
1270 1280 1290 1300 1310 1320
MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE ESLDKTSHSV GRRARYIVKN
1330 1340 1350 1360 1370 1380
PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN
1390 1400 1410 1420 1430 1440
LEIPNTLQEL FAKYRVLAIG DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS
1450 1460 1470 1480 1490 1500
CQSFQIFRLY REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS
1510 1520 1530 1540 1550 1560
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL VAFSLDSPGG
1570 1580 1590 1600 1610 1620
HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL GKDGGLDDDE EEEDLDEGSG
1630 1640 1650 1660 1670 1680
TKRQGVEVKA HQASHTKYLL MRGYYTVPGM VSTRNLNPND SIVVNSCQVK FRLRNTPAST
1690 1700 1710 1720 1730 1740
QLGPTGFTAT PLEELQAGLS CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL
1750 1760 1770 1780 1790 1800
EILQAVAAAD CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL
1810 1820 1830 1840 1850 1860
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV PPVSSHSTKK
1870 1880 1890 1900 1910 1920
RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE AQAPAQLAAP EDADAGGPRQ
1930 1940 1950 1960 1970 1980
ENQENVGVSG LEQLGCEFQL PEGSEDPRGL TESNMAQAAW ESGCERVCFV GRPWRGVDGH
1990 2000 2010 2020 2030 2040
LNMPVCKGML EAVLYHIMSR PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR
2050 2060 2070 2080 2090 2100
KPASVSLFSR PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH
L
Isoforms
- Isoform 2 of General transcription factor 3C polypeptide 1 - Isoform 3 of General transcription factor 3C polypeptide 1Sequence View
10 20 30 40 50 60
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA LATHPGISFY
70 80 90 100 110 120
EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI HMILENKDGI QGSCRYFKER
130 140 150 160 170 180
KDITSSIRSK CLQPRCTMVE AFSRWGKKLI IVASQDMRYR ALIGLEGDPD LKLPDFSYCI
190 200 210 220 230 240
LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI
250 260 270 280 290 300
LLLLNRFHVD RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA
310 320 330 340 350 360
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD DDEEVISKGV
370 380 390 400 410 420
PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK LEARMLCRLL QRFKVVKGFM
430 440 450 460 470 480
EDEGRQRTTK YISCVFAEES DLSRQYAREK ARGELLTTVS LASVQDESLM PEGEEAFLSD
490 500 510 520 530 540
SESEEESSCS GGKRRGRGSR GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA
550 560 570 580 590 600
EERSRRSSAC RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR
610 620 630 640 650 660
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSII
670 680 690 700 710 720
RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA
730 740 750 760 770 780
NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN SDPNTSSKPE STRVKKTDEK MGITPLKNYK
790 800 810 820 830 840
PVIVPGLGRS IGFLPKMPRL KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG
850 860 870 880 890 900
AQPSSGDDWD TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL
910 920 930 940 950 960
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ LLYKRRYIFS
970 980 990 1000 1010 1020
VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD TTICDPHYNL AHSSRPFERR
1030 1040 1050 1060 1070 1080
LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR CPCAQKICPD PGSDPEGSLR KEQESAMDKH
1090 1100 1110 1120 1130 1140
NLERKCAMLE YTTGSREVVD EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN
1150 1160 1170 1180 1190 1200
TSENGLTGRL QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN
1210 1220 1230 1240 1250 1260
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR MMTRLRVSWS
1270 1280 1290 1300 1310 1320
MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE ESLDKTSHSV GRRARYIVKN
1330 1340 1350 1360 1370 1380
PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN
1390 1400 1410 1420 1430 1440
LEIPNTLQEL FAKYRVLAIG DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS
1450 1460 1470 1480 1490 1500
CQSFQIFRLY REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS
1510 1520 1530 1540 1550 1560
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL VAFSLDSPGG
1570 1580 1590 1600 1610 1620
HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL GKDGGLDDDE EEEDLDEGSG
1630 1640 1650 1660 1670 1680
TKRQGVEVKA HQASHTKYLL MRGYYTVPGM VSTRNLNPND SIVVNSCQVK FRLRNTPAST
1690 1700 1710 1720 1730 1740
QLGPTGFTAT PLEELQAGLS CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL
1750 1760 1770 1780 1790 1800
EILQAVAAAD CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL
1810 1820 1830 1840 1850 1860
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV PPVSSHSTKK
1870 1880 1890 1900 1910 1920
RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE AQAPAQLAAP EDADAGGPRQ
1930 1940 1950 1960 1970 1980
ENQENVGVSG LEQLGCEFQL PEGSEDPRGL TESNMAQAAW ESGCERVCFV GRPWRGVDGH
1990 2000 2010 2020 2030 2040
LNMPVCKGML EAVLYHIMSR PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR
2050 2060 2070 2080 2090 2100
KPASVSLFSR PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH
L
10 20 30 40 50 60
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA LATHPGISFY
70 80 90 100 110 120
EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI HMILENKDGI QGSCRYFKER
130 140 150 160 170 180
KDITSSIRSK CLQPRCTMVE AFSRWGKKLI IVASQDMRYR ALIGLEGDPD LKLPDFSYCI
190 200 210 220 230 240
LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI
250 260 270 280 290 300
LLLLNRFHVD RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA
310 320 330 340 350 360
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD DDEEVISKGV
370 380 390 400 410 420
PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK LEARMLCRLL QRFKVVKGFM
430 440 450 460 470 480
EDEGRQRTTK YISCVFAEES DLSRQYAREK ARGELLTTVS LASVQDESLM PEGEEAFLSD
490 500 510 520 530 540
SESEEESSCS GGKRRGRGSR GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA
550 560 570 580 590 600
EERSRRSSAC RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR
610 620 630 640 650 660
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSII
670 680 690 700 710 720
RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA
730 740 750 760 770 780
NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN SDPNTSSKPE STRVKKTDEK MGITPLKNYK
790 800 810 820 830 840
PVIVPGLGRS IGFLPKMPRL KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG
850 860 870 880 890 900
AQPSSGDDWD TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL
910 920 930 940 950 960
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ LLYKRRYIFS
970 980 990 1000 1010 1020
VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD TTICDPHYNL AHSSRPFERR
1030 1040 1050 1060 1070 1080
LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR CPCAQKICPD PGSDPEGSLR KEQESAMDKH
1090 1100 1110 1120 1130 1140
NLERKCAMLE YTTGSREVVD EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN
1150 1160 1170 1180 1190 1200
TSENGLTGRL QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN
1210 1220 1230 1240 1250 1260
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR MMTRLRVSWS
1270 1280 1290 1300 1310 1320
MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE ESLDKTSHSV GRRARYIVKN
1330 1340 1350 1360 1370 1380
PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN
1390 1400 1410 1420 1430 1440
LEIPNTLQEL FAKYRVLAIG DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS
1450 1460 1470 1480 1490 1500
CQSFQIFRLY REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS
1510 1520 1530 1540 1550 1560
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL VAFSLDSPGG
1570 1580 1590 1600 1610 1620
HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL GKDGGLDDDE EEEDLDEGSG
1630 1640 1650 1660 1670 1680
TKRQGVEVKA HQASHTKYLL MRGYYTVPGM VSTRNLNPND SIVVNSCQVK FRLRNTPAST
1690 1700 1710 1720 1730 1740
QLGPTGFTAT PLEELQAGLS CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL
1750 1760 1770 1780 1790 1800
EILQAVAAAD CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL
1810 1820 1830 1840 1850 1860
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV PPVSSHSTKK
1870 1880 1890 1900 1910 1920
RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE AQAPAQLAAP EDADAGGPRQ
1930 1940 1950 1960 1970 1980
ENQENVGVSG LEQLGCEFQL PEGSEDPRGL TESNMAQAAW ESGCERVCFV GRPWRGVDGH
1990 2000 2010 2020 2030 2040
LNMPVCKGML EAVLYHIMSR PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR
2050 2060 2070 2080 2090 2100
KPASVSLFSR PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH
L
Protein Neighborhood
Domains & Features
4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q8K284-1-unknown | MDALES... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q8K284-1-unknown | MDALES... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt91936 | |||
| Q8K284-157-unknown | MRYRAL... | 157 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt91937 | |||
| Q8K284-157-unknown | MRYRAL... | 157 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt97785 | |||
| Q8K284-578-unknown | IAVIEE... | 578 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32520 | |||
| Q8K284-578-unknown | IAVIEE... | 578 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154298 | |||
| Q8K284-1604-unknown | GGLDDD... | 1604 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32522 | |||
| Q8K284-1604-unknown | GGLDDD... | 1604 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt200749 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...SHSGDI | 577 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32520 | |||
| ...SHSGDI | 577 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137719 | |||
| ...SLGKDG | 1603 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC32522 | |||
| ...KWIHL | 2101 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...KWIHL | 2101 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87554 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| GRAB_MOUSE | 577 | SGDI.|.IAVI | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
| GRAB_MOUSE | 1603 | GKDG.|.GGLD | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Analysis of protein processing ... (S01.010) | 18836177, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|